ISSN:
1432-1041
Keywords:
ketanserin
;
ketanserin-ol
;
pharmacokinetics
;
reduction-oxidation equilibrium
;
healthy volunteers
;
adverse effects
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The metabolic reduction-oxidation equilibrium between ketanserin and ketanserin-ol was studied after oral dosing of both substances to two healthy volunteers. Comparison of plasma Cmax and AUCs indicated that the equilibrium was shifted towards ketanserin-ol. There is evidence that ketanserin-ol elimination is the slowest step dictating the terminal half-life of ketanserin.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00981134
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