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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetic approach to equilibrium between ketanserin and ketanserin-ol (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 339-342 
    Details
    ISSN: 1432-1041
    Keywords: ketanserin ; ketanserin-ol ; pharmacokinetics ; reduction-oxidation equilibrium ; healthy volunteers ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The metabolic reduction-oxidation equilibrium between ketanserin and ketanserin-ol was studied after oral dosing of both substances to two healthy volunteers. Comparison of plasma Cmax and AUCs indicated that the equilibrium was shifted towards ketanserin-ol. There is evidence that ketanserin-ol elimination is the slowest step dictating the terminal half-life of ketanserin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00981134
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