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  • 1
    Electronic Resource
    Electronic Resource
    Stress constraints and hydrofracturing stress data for the continental crust (1986)
    Springer
    Pure and applied geophysics 124 (1986), S. 875-895 
    Details
    ISSN: 1420-9136
    Keywords: Stress constraints ; hydrofracturing ; faulting ; seismicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Faulting and seismicity in the upper continental crust require considerable differential stresses. Application of experimentally developed friction, fracture and flow laws shows that high differential stresses can only exist in the uppermost crust. Direct hydraulic fracturing measurements in deep boreholes seem to support this rock mechanics conclusion. The experimental data base presently consists of approximately 500 hydrofrac tests conducted in about 100 boreholes at about 30 different geographical locations. To illustrate the variation of measured stresses with depth, the data are expressed as dimensionless horizontal stresses in the formS H,h/Sv=(α/z)+β, whereS v=ρgz Extrapolation of the experimental data to greater depth shows that the minor horizontal stress approaches the valueS h/Sv=0.5 which limits friction on wet faults, and that the major horizontal stress approaches a value close toS H/Sv=1 at rather shallow depth (5 to 10 km.). This limits faulting and seismicity in most of the upper crust to either strike-slip or normal faults. The lower boundary for seismicity is mainly dependent on tectonic strain accumulation and rock creep at the environmental conditions at depth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00879616
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  • 2
    Electronic Resource
    Electronic Resource
    Book reviews (1995)
    Springer
    Journal of evolutionary economics 5 (1995), S. 91-96 
    Details
    ISSN: 1432-1386
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01199672
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of 6-thiouric acid and 6-mercaptopurine in renal allograft recipients after oral administration of azathioprine (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 265-271 
    Details
    ISSN: 1432-1041
    Keywords: azathioprine ; 6-thiouric acid ; 6-mercaptopurine ; renal transplantation ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The immunosuppressive activity of azathioprine (AZA) is unpredictable and depends on the formation of intracellular thiopurine ribonucleotides. However, the quantification of these active thiopurines presents difficult analytical problems. It has recently been postulated that plasma concentrations of 6-thiouric acid (6-TU) and 6-mercaptopurine (6-MP), metabolites of AZA, may provide more readily measurable indices of the pharmacologic activity of AZA. In order to evaluate the utility of 6-TU and 6-MP plasma concentrations in monitoring AZA therapy, we studied their pharmacokinetics in 6 renal transplant patients, and their in vitro immunosuppressive potency in a mixed lymphocyte proliferation assay. A peak plasma 6-TU concentration of 710.7 ng/ml was observed at 3.8 h after oral dosing. Good correlation was observed between the elimination t1/2 of 6-TU and serum creatinine, and between AUC over 24 h and serum creatinine. However, we did not observe a second peak in plasma 6-TU concentration that could be attributed to the degradation of active AZA metabolites. 6-MP plasma concentrations in the patients were low (mean peak concentration 36.0 ng/ml) and rapidly disappeared within 8 h. In vitro immunosuppressive activity could not be demonstrated for 6-TU over a concentration range of 1.25 ng/ml to 0.25 mg/ml. We conclude that 6-TU is pharmacologically inert and is primarily eliminated by the kidneys. Our findings currently do not support the use of plasma concentrations of 6-TU or 6-MP to monitor AZA therapy. In order to optimize AZA therapy, analytical techniques that are technically feasible and that can directly quantify the active intracellular thiopurines are being explored.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558158
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  • 4
    Electronic Resource
    Electronic Resource
    Interaction between physiological and cognitive determinants of emotions: Experimental studies on Schachter's theory of emotions
    Amsterdam : Elsevier
    Biological Psychology 6 (1978), S. 61-74 
    Details
    ISSN: 0301-0511
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Psychology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0301-0511(78)90007-8
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  • 5
    Electronic Resource
    Electronic Resource
    Dynamic and regional aspects of polyamine metabolism in the brain of trout (Salmo irideus Gibb.)
    Amsterdam : Elsevier
    International Journal of Biochemistry 10 (1979), S. 961-974 
    Details
    ISSN: 0020-711X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0020-711X(79)90075-2
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  • 6
    Electronic Resource
    Electronic Resource
    Lateralization and autonomic reactivity with emotional stimulation
    Amsterdam : Elsevier
    International Journal of Psychophysiology 14 (1993), S. 131 
    Details
    ISSN: 0167-8760
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-8760(93)90186-S
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  • 7
    Electronic Resource
    Electronic Resource
    Listeriose der Neugeborenen: Granulomatosis infantiseptica (1953)
    Springer
    European journal of pediatrics 73 (1953), S. 113-132 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. 10 Fälle von Listeriose beim Neugeborenen (Granulomatosis infantiseptica), 7 davon bei Frühgeburten werden beschrieben. 2. Das aus den Einzelfällen abzuleitende Krankheitsbild äußert sich in mangelhafter Reife der Neugeborenen, Neigung zu Atem- und Kreislaufstörungen, Trinkschwäche, Fieber Leber- und Milztumor, Leptomeningitis. Diagnostisch wichtig sind ferner Granulome in der Haut, besonders am Stamm und den unteren Extremitäten, sowie in der Schleimhaut der Rachenhinterwand. 3. Die klinische Verdachtsdiagnose wird bei letal verlaufenen Fällen gesichert durch pathologisch-anatomische Befunde in Verbindung mit dem bakteriologischen Nachweis (mikroskopisch und kulturell) von Listeria infantiseptica in Ausscheidungen und Organen; in vivo gelingt die Diagnose der Erkrankung durch Bakteriennachweis aus Meconium (bzw. Urin) in Verbindung mit spezifischer Agglutinations- (oder Präzipitations-) Reaktion. 4. Differentialdiagnostisch sind abzugrenzen: Lebensschwäche bei Frühgeburten, Fruchtwasseraspiration, intrakranielle Blutungen infolge Geburtstrauma, Sepsis und Meningitis durch andere Erreger, Lues connatalis, evtl. Icterus gravis. 5. Die Heilung eines Falles von Listeriose beim Säugling erfolgte durch kombinierte Penicillin-Sulfonamid-Behandlung. Akut fieberhafte Erkrankungen während der Schwangerschaft, besonders solche mit cystopyelitischen Beschwerden, geben anamnestisch einen wichtigen Hinweis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00438260
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  • 8
    Electronic Resource
    Electronic Resource
    Aminostickstoff-Bilanz bei der Aminofusin-Behandlung schwerer akuter Ernährungsstörungen im Säuglingsalter (1960)
    Springer
    Journal of molecular medicine 38 (1960), S. 1001-1002 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01484317
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  • 9
    Electronic Resource
    Electronic Resource
    Zur Nierenverträglichkeit parenteral verabreichter Sorbitlösungen (1960)
    Springer
    Journal of molecular medicine 38 (1960), S. 1002-1003 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01484318
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  • 10
    Electronic Resource
    Electronic Resource
    Über die Verteilung von 3H-Putrescin und 3H-Spermin in meroistischen Ovariolen von Musca domestica und ihre Beziehung zum Nucleinsäurenstoffwechsel (1974)
    Springer
    Histochemistry and cell biology 40 (1974), S. 361-369 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Hausfliegen wurde radioaktiv markiertes Putrescin, Spermin sowie Uridin intraabdominal injiziert und die Verteilung der Radioaktivität nach 1- und 3stündiger Inkorporation in den meroistischen Ovarien autoradiographisch bestimmt. Im Unterschied zu 3H-Uridin und 3H-Spermin, welche die Nährzellen sehr stark, die Oocyte dagegen gar nicht markieren, wird 3H-Putrescin in Semidünnschnitten vorwiegend im Ooplasma, jedoch nicht im Kern der Eizelle angetroffen. Diese Ergebnisse werden mit Befunden entsprechender Untersuchungen am panoistischen Ovar der Heuschrecke verglichen und die Unterschiede, insbesondere bezüglich der Verteilung von 3H-Putrescin im Zusammenhang mit der unterschiedlichen Lokalisation der Nucleinsäuren-synthetisierenden Strukturen beider Ovariolen-Typen diskutiert.
    Notes: Summary Radioactive labelled putrescine, spermine, and uridine were injected intraabdominally into house flies (Musca domestica), and the distribution of radioactivity in the ovaries was autoradiographically determined after 1 and 3 hrs incorporation time. In contrast to a hight labelling of nurse cells, the oocytes were not labelled by 3H-uridine or 3H-spermine. In semithin sections Putrescine was found predominantly in the ooplasm, but not in the nucleus of the ovum. These results were compared with the results of similar experiments with grashoppers panoistic ovaries. The differences, especially in the distribution of putrescine, are discussed in these two types of ovaries in relation to their different localization of nucleic acid synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00495043
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