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  • 1
    Electronic Resource
    Electronic Resource
    Failure of calcitriol treatment in a patient with malignant osteopetrosis (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 818-821 
    Details
    ISSN: 1432-1076
    Keywords: Malignant infantile osteopetrosis ; Calcitriol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In an attempt to stimulate bone resportion, a 10-week-old infant with malignant infantile osteopetrosis was treated with high doses of calcitriol, a potent bone resorption stimulatory agent, combined with a low calcium diet to prevent hypercalcaemia. Although calcitriol administration was initiated at this very young age, our patient did not show any clinical, radiological, or histological improvement. Despite reports of positive results of this treatment in the literature, our patient did not reveal any signs of bone resorption. She eventually died from the complications of osteopetrosis at the age of 6 months after 88 days of therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02073378
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  • 2
    Electronic Resource
    Electronic Resource
    Megadose methylprednisolone treatment for malignant osteopetrosis (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 779-780 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01954503
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  • 3
    Electronic Resource
    Electronic Resource
    Selective inhibition of cysteine proteinases by Z-Phe-AlaCH"2F suppresses digestion of collagen by fibroblasts and osteoclasts
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 178 (1991), S. 178-184 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(91)91796-F
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  • 4
    Electronic Resource
    Electronic Resource
    Experimental gingivitis in relation to susceptibility to periodontal disease II. Phase-contrast microbiological features and some host-response observations (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 13 (1986), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract In the present investigation, a number of histological and immunohistochemical characteristics of periodontal tissues as well as the phase-contrast microscopy of dental plaque were studied after experimentally-induced gingival inflammation in relation to susceptibility to periodontal disease. The study included a younger (mean age 34.1 years) and an older age group (mean age 48 years) with a reduced but healthy periodontium. Both age groups had the same amount of loss of attachment which may suggest that they had different degrees of susceptibility to periodontal disease. At the start of the experiment, each patient was instructed to abstain from oral hygiene in one quadrant of the mouth for a period of 18 days. At the end of the 18-day period, supra-gingival plaque and gingival tissue samples were taken. As determined by phase-contrast microscopy, the plaque samples of both age groups contained relatively high proportions of spirochetes. This may indicate that the patients are at risk for recurrence of periodontal breakdown. The general histopathologic picture of the gingival tissue samples of both age groups was similar to the so-called ‘early lesion’. However, IgA-producing plasma cells were found in most tissue samples of both age groups. The first part of this study showed that the younger, in comparison to the older, patients developed inflammation in terms of bleeding on probing more rapidly. These clinical results cannot be explained by the host-parasite parameters investigated in the present study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.1986.tb00846.x
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  • 5
    Electronic Resource
    Electronic Resource
    Collagen Resorptlon in the Gingiva of the Mouse Incisor (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 7 (1980), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.1980.tb01989.x
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  • 6
    Electronic Resource
    Electronic Resource
    Microtubules in periodontal ligament cells in relation to tooth eruption and collagen degradation (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 19 (1984), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effects of the anti-microlubular drug colchicine on the eruption of the continuously growing mouse incisor and the structure of its periodontal ligament, which is thought to be responsible for generating the eruptive force were studied. It was observed that both the eruptive process and the microtubular apparatus in the cells of the ligament are affected by the drug in a dose-dependent fashion, thereby lending support to the view that eruption is related to the functioning of microtubules in periodontal ligament cells. Since colchicine did not seem to interfere with collagen degradation. as measured in terms of collagen phagocytosis by fibroblasts and loss of connective tissue attachment in the supra-alveolar region, the inhibition of eruption is not likely to be due to an increased resistance force in the periodontal ligament as a result of decreased collagen breakdown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1984.tb01304.x
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  • 7
    Electronic Resource
    Electronic Resource
    Quantitative analysis of connective tissue resorption in the supra-alveolar region of the mouse incisor ligament (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 17 (1982), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: During eruption of the mouse incisor part of the periodontal ligament moves along with the tooth in the occlusal direction and is degraded in the supra-alveolar region.In the present study stereologic analysis at the ultrastructural level has shown that significant reduction of the amount of extracellular collagen is confined to the most occlusal region of the ligament, just apically to the functional epithelium. In connection herewith a relatively high amount of homogeneous material of moderate electron density was found in the intercellular space, suggesting a process of extracellular collagen breakdown near the epithelium-connective tissue interface.With respect to the distribution of collagen phagocytosis by fibroblasts, it appeared that the volume density of cytoplasmic vacuoles containing collagen fibrils was considerably higher in the supra-alveolar region of the ligament than in its subcrestal part, particularly in the zone along the tooth surface. This phenomenon is interpreted as being indicative of increased phagocytic activity of fibroblasts leading to the detachment of the periodontal ligament from the cemeatum before it enters the region of final degradation near the apical termination of the junctional epithelium.In an attempt to identify the cells involved in the degradation of (fragments of) periodontal fibroblasts in the supra-alveolar region, periodontal ligament cells were labelled with tritiated thymidine at their site of origin. By means of both autoradiography and electron microscopy, it was shown that, following the arrival of Jabelled fibroblasts in the supra-alveolar region, at least part of the degradation of cellular constituents is accomplished via a process of heterophagocytosis among fibroblasts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1982.tb01171.x
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  • 8
    Electronic Resource
    Electronic Resource
    Loss of attachment in the marginal periodontium of the rat incisor under non-inflammatory conditions (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 31 (1996), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Alkaline phosphatase (ALP) has been suggested to play a role in acellular cementum formation and maintenance of periodontal attachment. In an attempt to determine whether changes in attachment level are associated with altered expression of ALP-activity in the periodontium we induced natural loss of attachment in rats by pinning the lower incisor to the jaw bone. Previous studies have shown that this procedure results in regressive changes in the marginal periodontium without any inflammatory response. Six months after blockage of eruption the attachment level on the experimental (right) side had shifted about 700 μ in the apical direction. On the control (left) side the apical termination of the junctional epithelium had remained stationary with respect to the alveolar crest. Our observations have shown that during the first few weeks of the experiment loss of attachment is accompanied by considerable reduction of ALP-activity in the supracrestal part of the periodontium. At later time intervals, however, no distinct relation was found between apical migration of junctional epithelium and loss of ALP-activity in the supracrestal region, indicating that the two phenomena are not directly related to each other. The domain of the ALP-positive fibroblasts in the supracrestal extension of the periodontal ligament decreased in size and was replaced by ALP-negative connective tissue cells probably coming from the outer gingival domain. Since at all time intervals a distinct demarcation could be observed between the ALP-positive and ALP-negative areas, we interpret our data as indicating that ligament and gingival cells do not mix.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1996.tb00465.x
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  • 9
    Electronic Resource
    Electronic Resource
    Cell-bound and extracellular matrix-associated alkaline phosphatase activity in rat periodontal ligament (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 31 (1996), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In previous studies it was noted that alkaline phosphatase (ALP) activity in periodontal ligament does not only seem to be related to cells but may also be associated with the extracellular matrix. In an attempt to clarify this we studied the distribution of the enzyme at the electron microscopic level. In addition, ALPactivity was assessed biochemically following extraction of the ligament with (i) agents dissolving the membrane or splitting the phosphatidylinositol anchor (Triton X-100 or phosphatidylinositol-phospholipase C, respectively), and (ii) a matrix-degrading enzyme cocktail (collagenase, hyaluronidase and elastase). Histochemical observations revealed (a) a heterogeneous distribution of ALP-activity, with highest activity adjacent to the alveolar bone and (b) two pools of activity; one bound to cells and one associated with the collagenous extracelluJar matrix. In line with this were the biochemical data indicating that approximately 10% of the enzyme activity was firmly bound to the extracellular matrix and 90% to plasma membranes. Isoelectric focusing did not reveal differences between the two fractions, both samples yielding a single broad band corresponding with an isoelectric point of about 4.4.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1996.tb00466.x
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  • 10
    Electronic Resource
    Electronic Resource
    Junctions between fibroblasts in mouse periodontal ligament (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 15 (1980), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Quantitative evaluation of the distribution of intercellular junctions between fibroblasts in the incisor and molar periodontal ligament of the mouse indicated that structures resembling gap junctions are more frequent on the tooth side of this tissue than on the bone side. The difference was particularly evident for the ligament of the continuously erupting incisor. Here, the numerical density of gap junction-like structures was estimated to be approximately 20 per fibroblast in the connective tissue adjacent to the cementum and 4 per fibroblast in the tissue along the alveolar bone. With regard to the distribution of adhaerens-type junctions less variation was observed between the various zones of the incisor and molar ligament. For the incisor the average number of adhaerens-type junctions was calculated to be in the order of 30 junctions per cell in the tooth-related compartment and 20 junctions per cell in the alveolar compartment.Although in the molar intercellular junctions were observed throughout the entire width of the ligament, in the incisor they were confined to the two main connective tissue compartments, i.e. the one of the tooth side which moves with the erupting tooth in the direction of the oral cavity, and the one of the bone side which remains stationary with respect to the alveolar wall. In the transitional area between the two latter compartments junctions were very sparse. It is suggested that the distribution pattern of intercellular junctions between fibroblasts in mouse periodontal ligament reflects functional differences among the cells in the various regions of the tissue, differences that are possibly related to processes involving the movement of cells and the metabolism of collagen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1980.tb00326.x
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