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Digitale Medien

In vitro activity of biapenem against beta-lactamase producingEnterobacteriaceae (1994)

Alonso, R. ; Fdez-Aranguiz, A. ; Colom, K. ; [weitere]

Springer

European journal of clinical microbiology & infectious diseases 13 (1994), S. 820-822

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Details

ISSN: 1435-4373

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract The activity of biapenem was compared with that of imipenem and cefotaxime against 108 strains of β-lactamase producingEnterobacteriaceae. Biapenem and imipenem were very active, inhibiting 90 % of the strains at a concentration of 0.5 µg/ml. Both carbapenems were very active against plasmidic β-lactamase producers, with MIC90s below 1 µg/ml. However, the MIC90 of biapenem for cephalosporinase producers was 1 µg/ml. Against strains producing extended-spectrum β-lactamases, biapenem exhibited better activity against TEM-type producers (MIC90 0.25 µg/ml) than against SHV-type producers (MIC90 0.5 µg/ml). Overall, the in vitro antibacterial activity of biapenem is similar to that of imipenem.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02111342

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