ISSN:
1432-1041
Keywords:
cyclophosphamide
;
cytostatic drug
;
cancer therapy
;
female breast cancer
;
bioavailability
;
rapid release formulations
;
gastric juice resistant formulation
;
pharmacokinetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Cyclophosphamide (CP) is an alkylating cytostatic compound, which is activated to its cytotoxic form in the liver [1]. Since the therapeutic range of CP in the treatment of human tumours, is small like other cytostatics, a constant high bioavailability is essential for its oral administration. Although CP has become one of the most widely used cytostatics [2], there do not appear to have been any bioavailability investigations providing the necessary information. The development of a very sensitive gas chromatographic analytical method has now permited investigation of the pharmacokinetics of oral CP in conventional clinical doses [3, 4, 5, 6].
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00630298
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