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  • 1
    ISSN: 0942-0940
    Keywords: Keywords: Aneurysmal subarachnoid haemorrhage; long-term effects; quality of life; rehabilitation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  Although physical and emotional dysfunction appears to be quite frequent even among independent survivors of aneurysmal subarachnoid haemorrhage (SAH), these symptoms may easily be missed on routine follow-up examinations. To assess the long-term functional effects of SAH and to outline possible treatment approaches, a cross-sectional study using multidimensional measures of relevant areas of function was performed on 40 independent survivors. After an average follow-up period of 22 months, patients were selected and enrolled following a pre-designed protocol. The comprehensive test battery consisted of subjective and objective measures of physical, psychological and social function and relationships between the different levels of assessment were calculated. We found a considerable proportion of cognitive, emotional and physical dysfunction in this sample, but on the subjective level, the majority of the patients stated satisfaction with life in general. Mild cognitive dysfunction was frequently missed and causes distress in the family. Mild to moderate depression was underdiagnosed, although such an emotional dysfunction influences working capacity and quality of life. Referral to rehabilitation centers appears to be restricted to patients with severe impairments. Our results help to alert the neurosurgeon to these possible symptoms and show the urgent need for a prospective, interdisciplinary and multidimensional follow-up of SAH survivors.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neural transmission 3 (1991), S. 41-47 
    ISSN: 1435-1463
    Keywords: Melatonin ; Parkinson's disease ; 1-dopa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Although several studies on the efficacy and the toxicity of exogenous melatonin in Parkinson patients have been carried out, there are no data available on melatonin secretion in these patients. We therefore performed a controlled trial in 9 Parkinson patients (aged 62.1±8.7 years, ×±SD) and in 14 control persons (58.0±10.4 years). Parkinson patients were treated with 1-dopa (300–1000 mg per day) in combination with a peripheral decarboxylase inhibitor (benserazide, carbidopa). 14 venous blood samples were taken from each person during a period of 24 hours in order to investigate the circadian secretion pattern of melatonin. Serum melatonin levels were estimated by radioimmuno assay. We found that the circadian secretion patterns of 1-dopa-treated Parkinson patients and age-matched controls were very similar except for a phase advance of the nocturnal melatonin elevation in the parkinsonian group.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neural transmission 5 (1993), S. 157-161 
    ISSN: 1435-1463
    Keywords: Parkinson's disease ; sports ; physical activity ; exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Physical activity during lifetime was investigated among 32 Parkinson patients (age 65.6±8.1 yrs, mean±SD) retrospectively by means of a structured interview. Data were compared with 31 healthy controls (age 61.7±5.8 yrs). An objective score was obtained by presenting a list of all kinds of sports, subjective estimation of physical activity was done by visual analogous scales. Until the occurrence of the first symptoms (mean=58.5 yrs) the patients did not differ from controls. During the course of disease a striking reduction in physical activity but no complete abandonment of sports was found. Swimming, hiking and gymnastics were the favoured sports in both groups. Learning of new sports seemed to be impossible for the patients.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1435-1463
    Keywords: Melatonin ; Parkinson's disease ; l-dopa ; phase shift ; tremor ; human circadian rhythm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Aim of this study was the characterization of the circadian melatonin profile in de novo Parkinson patients (N=9, age 60.0±3.2 years, mean ± SEM) and the comparison of these profiles with those of controls and Parkinson patients treated with I-dopa/decarboxylase inhibitor (l-dopa/DCI). We collected 14 venous blood samples during a period of 24 hours and measured the serum melatonin levels by a radioimmuno assay. De novo Parkinson patients displayed the nocturnal melatonin peak (acrophase) at the same time as controls and significantly later than l-dopa/DCI treated patients (1:54±15.6 min [average clock time ± SEM in minutes] vs. 1:45±15.6 min vs. 0:13±40.8 min). The amount of secreted melatonin did not differ among the three groups. Stage and duration of Parkinson's disease did not correlate with the amount of secreted melatonin. Patients of the tremor subgroup, however, secreted more melatonin than patients presenting only with rigidity and akinesia. The phase advance in Parkinson patients treated with l-dopa/DCI is possibly due to a central nervous dopaminergic effect elicited by l-dopa administration and not inherent to Parkinson's disease per se.
    Type of Medium: Electronic Resource
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