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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 25 (1973), S. 281-290 
    ISSN: 1432-0533
    Keywords: Paramyxovirus ; Nucleocapsids ; Multiple Sclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In four of seven MS brain biopsies (not from the neighbourhood of a lesion) tubular structures resembling the nucleocapsids of a paramyxovirus have been seen sometimes in considerable numbers. They were not seen in non-MS material. Should they turn out to be truly paramyxovirus in origin, the activity of the virus might be direct or indirect in pathogenesis of MS.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 15 (1970), S. 288-292 
    ISSN: 1432-0533
    Keywords: Electron Microscopy ; Kuru ; Inclusion ; Cytoplasmic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In Fällen von Kuru wurden im Cytoplasma von ansonst normalen Purkinjezellen Strukturen mit strahlendichten Balkenmustern gefunden. Solche sind auch in geringerer Zahl im Axoplasma von Nervenfasern sowohl im menschlichen wie auch im Schimpansenmaterial vorhanden. Sie weisen eine zarte Punktstruktur auf sind und eng mit intracellulären Membranprofilen verbunden.
    Notes: Summary Within the cytoplasm of otherwise normal Purkinje cells barred structures have been found in cases of Kuru. They are also present in small numbers in axoplasm of nerver fibres, both in human and chimpanzee material. They present a discrete punctate structure and are closely associated with intracellular membranous profiles.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 4 (1964), S. 200-211 
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die elektronenmikroskopische Untersuchung von Gehirnen Scrapie-kranker Mäuse zeigte, daß durch die Erweiterung der Räume des endoplasmatischen Reticulums in den Nervenzellen kleine Bläschen entstehen. Die in den Paraffinschnitten zu sehenden Vacuolen entsprechen einer starken Verdickung von Nervenfasern oder einer Schwellung und möglichen Konfluenz von Astrocytenfortsätzen. Verbreitet bestehen degenerative Markscheidenveränderungen. Dichte Gebilde (dense bodies) oder pleomorphe Einschlüsse sind häufig in Nervenzellen anzutreffen. Es wird vermutet, daß die Astrogliahypertrophie mit der Ernährung der Nervenzellen interferiert, so daß infolge der Dysfunktion der Neuroglia eine neuronale Störung entsteht.
    Notes: Summary Electron microscopic examination of mouse scrapie brain has shown small vesicles in nerve cells to be formed by dilatation of endoplasmic reticulum sacs. Vacuoles seen in paraffin sections are due to great dilatation of nerve fibres, or swelling and possible confluence of astrocyte processes. Myelin degenerative changes were widespread. Dense bodies and pleomorphic inclusions were common in nerve cells. It is suggested that astroglial hypertrophy may interfere with nerve cell nutrition so that nervous disturbance results from neuroglial dysfunction.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 8 (1967), S. 47-56 
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In den Gehirnen von Scrapie-kranken Ratten wurden wohlgeformte Amyloidkörperchen mit deutlicher konzentrischer Schichtung und kleinere amyloide Massen gefunden. Amyloid scheint sich in Astrocytenfortsätzen und Gliazellkörpern sowie in geschrumpften Nervenzellen zu bilden. Selten ist es in degenerierten Achsenzylindern vorhanden. Die Einzelfibrillen, welche die Amyloidablagerungen aufbauen, scheinen spiralige Form zu haben. Die großen im Lichtmikroskop sichtbaren Ablagerungen sind gewöhnlich auffallend symmetrisch im Gehirn lokalisiert.
    Notes: Summary Both well formed amyloid bodies showing clear concentric lamination and smaller masses of amyloid material have been found in the brains of rats suffering from scrapie. Amyloid appears to form within astrocyte processes and glial cell bodies, as well as shrunken nerve cells. Rarely, it was present in degenerate axis cylinders. The individual fibrils which make up amyloid deposits appeared to have a spiral constitution, and deposits large enough to be seen in the light microscope were commonly strikingly symmetrically located.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 122 (1965), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 122 (1965), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 197 (1963), S. 1218-1218 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A material capable of producing disease in twelve out of twelve guinea pigs (about 500 g weight) when 1 pig was injected with Freund's adjuvants has been isolated from fresh human post-mortem brain. It was obtained by a method differing from that of Kies et al.3 only in so far as special ...
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 174 (1954), S. 182-182 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The treated animals showed a striking failure to grow, or in some'eases a retarded growth followed by loss of body weight ending in death (Fig. 1). Such animals presented all the signs of pituitary failure (Fig. 2). They were small and shrivelled, with very little subcutaneous fat and a marked ...
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 221 (1969), S. 1265-1266 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Mice were infected with Riley agent by intraperitoneal injection of 0-2 ml. of a ten-fold dilution in saline (10-1) of plasma from a mouse bearing Ehrlich ascites tumour which had been serially maintained by one of us (D. H. A.) in this unit. Three months later plasma was withdrawn from a mouse and ...
    Type of Medium: Electronic Resource
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