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  • 1
    Electronic Resource
    Electronic Resource
    Obesity induced by unspecific early postnatal overfeeding in male and female rats: hypophagic effect of CCK-8S (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 354 (1996), S. 374-378 
    Details
    ISSN: 1432-1912
    Keywords: CCK-8S ; Feeding ; Obesity ; Rat ; Sex ; Unspecific early postnatal overfeeding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The response to cholecystokinin (CCK) as a satiety peptide in obesity or anorexia has been tested mainly in extreme models of food intake control. In the present study, the effect of CCK-8S on food intake was investigated in a nongenetic and less-stressful model of obesity due to unspecific early postnatal overfeeding in male and female rats. Reducing the normal litter size of ten to three newborn rats on day 3 of life led to an enhanced food intake resulting in an increased body weight until adulthood. Freely fed male and female, normal and obese rats were given 10 μg/kg CCK-8S i.p. on day 41 and 40 μg/kg CCK-8S on day 91 of life and food intake was measured for 24 h. Compared with treatment with saline (i.p.) 1 day before the test, the lower dose of 10 μg/kg CCK-8S reduced food intake for 2 h in normal, but not in obese rats. Conversely, the higher dose of 40 μg/kg CCK-8S reduced food intake in both normal and obese rats for 2 h, but this effect was more evident in the obese rats. Moreover, the satiating effect of CCK-8S was more pronounced and longer lasting in male than in female rats. In summary, the data suggest that the response to CCK-8S differs in normal and obese rats and depends on sex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171071
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Obesity induced by unspecific early postnatal overfeeding in male and female rats: hypophagic effect of CCK-8S (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 354 (1996), S. 374-378 
    Details
    ISSN: 1432-1912
    Keywords: Key words CCK-8S ; Feeding ; Obesity ; Rat ; Sex ; Unspecific early postnatal overfeeding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The response to cholecystokinin (CCK) as a satiety peptide in obesity or anorexia has been tested mainly in extreme models of food intake control. In the present study, the effect of CCK-8S on food intake was investigated in a nongenetic and less-stressful model of obesity due to unspecific early postnatal overfeeding in male and female rats. Reducing the normal litter size of ten to three newborn rats on day 3 of life led to an enhanced food intake resulting in an increased body weight until adulthood. Freely fed male and female, normal and obese rats were given 10 μg/kg CCK-8S i.p. on day 41 and 40 μg/kg CCK-8S on day 91 of life and food intake was measured for 24 h. Compared with treatment with saline (i.p.) 1 day before the test, the lower dose of 10 μg/kg CCK-8S reduced food intake for 2 h in normal, but not in obese rats. Conversely, the higher dose of 40 μg/kg CCK-8S reduced food intake in both normal and obese rats for 2 h, but this effect was more evident in the obese rats. Moreover, the satiating effect of CCK-8S was more pronounced and longer lasting in male than in female rats. In summary, the data suggest that the response to CCK-8S differs in normal and obese rats and depends on sex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171071
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Locomotor effects of lisuride: A consequence of dopaminergic and serotonergic actions (1985)
    Springer
    Psychopharmacology 85 (1985), S. 464-468 
    Details
    ISSN: 1432-2072
    Keywords: Dopamine agonist ; Lisuride ; Apomorphine ; Locomotor activity ; Serotonin agonist ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The open-field test was used to study the involvement of serotonergic and dopaminergic mechanisms in the action of lisuride on locomotor activity in the rat. Lisuride produced a biphasic locomotor effect. The maximum locomotor stimulatory response of lisuride was stronger than that of apomorphine and comparable with that of apomorphine and LSD combined. Hypermotility induced by high doses of lisuride was partially suppressed by the serotonin antagonist cyproheptadine and not further enhanced by LSD. A moderate dose of lisuride potentiated apomorphine-induced hypermotility in the same manner as has been shown for LSD. Lesion of dopaminergic structures within the median raphe nucleus by 6-OHDA produced a potentiation of lisuride-induced hypermotility. This effect was suppressed by cyproheptadine. The locomotor inhibitory effect of low doses of lisuride may be related to a stimulation of presynaptic mesolimbic dopamine receptors. It is concluded that the locomotor stimulant effect of higher doses of lisuride may depend on stimulation of postsynaptic dopamine receptors and a scrotonergic action and that the locomotor effects of lisuride reflect a complex interaction at dopaminergic and serotonergic transmission systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429666
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Atypical neuroleptics suppress dopaminergic behavioral supersensitivity (1990)
    Springer
    Psychopharmacology 100 (1990), S. 399-403 
    Details
    ISSN: 1432-2072
    Keywords: 6-Hydroxydopamine lesion ; Nucleus accumbens ; Dopaminergic supersensitivity ; Locomotor activity ; Atypical neuroleptics ; Serotonin antagonists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Seven days after bilateral 6-OHDA denervation of the nucleus accumbens locomotor activity was recorded in rats. 6-OHDA lesion strongly enhanced hypermotility induced by apomorphine (1.0 mg/kg IP) as a sign of behavioral dopaminergic supersensitivity. The potency of the classical neuroleptic haloperidol (0.03–0.25 mg/kg IP) to antagonize apomorphine-induced hypermotility was reduced in 6-OHDA-pretreated rats. The atypical neuroleptics sulpiride (5.0–20.0 mg/kg IP), thioridazine (1.0–5.25 mg/kg IP) and clozapine (0.5–2.0 mg/kg IP) and the 5-HT antagonists cyproheptadine (0.2 mg/kg IP) and ritanserin (0.01 mg/kg IP) suppressed the augmented apomorphine response in 6-OHDA-lesioned animals to the level of the apomorphine effect in controls. It is concluded that the model of denervation supersensitivity is capable of differentiating typical and atypical neuroleptics. The abolition of the 6-OHDA-induced increase of the apomorphine hypermotility by the atypical neuroleptics cannot be explained solely by postsynaptic dopamine receptor antagonism. Serotonergic mechanism may be involved in this action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244614
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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