ISSN:
1432-1912
Keywords:
Key words CCK-8S
;
Feeding
;
Obesity
;
Rat
;
Sex
;
Unspecific early postnatal overfeeding
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The response to cholecystokinin (CCK) as a satiety peptide in obesity or anorexia has been tested mainly in extreme models of food intake control. In the present study, the effect of CCK-8S on food intake was investigated in a nongenetic and less-stressful model of obesity due to unspecific early postnatal overfeeding in male and female rats. Reducing the normal litter size of ten to three newborn rats on day 3 of life led to an enhanced food intake resulting in an increased body weight until adulthood. Freely fed male and female, normal and obese rats were given 10 μg/kg CCK-8S i.p. on day 41 and 40 μg/kg CCK-8S on day 91 of life and food intake was measured for 24 h. Compared with treatment with saline (i.p.) 1 day before the test, the lower dose of 10 μg/kg CCK-8S reduced food intake for 2 h in normal, but not in obese rats. Conversely, the higher dose of 40 μg/kg CCK-8S reduced food intake in both normal and obese rats for 2 h, but this effect was more evident in the obese rats. Moreover, the satiating effect of CCK-8S was more pronounced and longer lasting in male than in female rats. In summary, the data suggest that the response to CCK-8S differs in normal and obese rats and depends on sex.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00171071
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