Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Journal of neurochemistry
27 (1976), S. 0
ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Abstract— Guanylate cyclase activity of dark-adapted bovine rod outer segments demonstrates a biphasic pattern upon exposure to light. By 10 s of illumination, activity is 20% lower than that observed in dark-adapted outer segments. Activity subsequently increases and then slowly declines to two-thirds of the original activity after 10 min of illumination. In the presence of GTP or ATP, hydrolysis of cyclic GMP is rapidly enhanced by exposure of outer segments to light; the magnitude of this effect is dependent on the amount of substrate present. The rapid effects of light on synthesis and degradation of cyclic GMP indicate that these reactions may be involved in the visual process. The concentration of guanosine 3′:5′-cyclic monophosphate (cyclic GMP) is extraordinarily high in dark-adapted bovine rod outer segments and is at least 100-fold that of adenosine 3′:5′-cyclic monophosphate (cyclic AMP). No significant decrease in the level of cyclic GMP or cyclic AMP was observed however upon exposure of dark-adapted outer segments to light.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1976.tb10399.x
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