ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Zinc ionophores, molecules that carry zinc ions across the cell membrane, can decrease apoptosis in animals subjected to experimental heart attack, brain injury, neurodegeneration, and epilepsy. Here we show that zinc ionophores at low μg/kg BW doses have neuroprotective effects in three different stroke models in rodents: focal ischemia models (middle cerebral artery occlusion, MCAO) in mice and rats, and a model of global ischemia (four vessel occlusion, 4VO) in rats. Intravenous, postinjury, administration of zinc ionophores decreased neuronal cell death, the number of TUNEL-positive cells in the lesioned brain areas, and brain infarct volumes. Zinc ionophores also significantly accelerated functional recovery after MCAO.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1046/j.1471-4159.85.s2.28.x
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