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  • 1
    Electronic Resource
    Electronic Resource
    Copenhagen : Munksgaard International Publishers
    Immunological reviews 179 (2001), S. 0 
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary: Enhanced serum IgE levels in adults and children with HIV-1 infection could be a marker of poor prognosis. HIV-1 infection is believed to involve a switch toward a “TH2-like” cytokine pattern. HIV-1 gp120 from different clades is a potent stimulus for histamine release from human basophils and mast cells. Gp120 also induces IL-4 and IL-13 synthesis from basophils. It functions as a viral superantigen by interacting with the VH3 region of IgE to induce mediator release from human FcεRI+ cells. The chemokine receptor CCR3, which binds the chemokines eotaxin and RANTES, is expressed by basophils and lung mast cells. By interacting with the CCR3 receptor on FcεRI+ cells, HIV-1 Tat protein is a potent chemoattractant for basophils and lung mast cells. Tat protein also induces IL-4 and IL-13 release from basophils. Incubation of basophils with Tat protein upregulates the surface expression of the CCR3 receptor, a co-receptor of HIV-1 infection. Extracellular Tat affects the directional migration of human FcεRI+ cells, CCR3 expression and TH2 cytokines release. We have shown that HIV-1 proteins gp120 and Tat trigger the release of cytokines critical for TH2 polarization from FcεRI+ cells through two distinct mechanisms. In addition, Tat upregulates the β-chemokine receptor CCR3, making FcεRI+ cells more susceptible to infection with CCR3 tropic HIV-1 isolates.This paper is dedicated to Rita Levi-Montalcini who first suggested an involvement of FcεRI+ cells in HIV-1 infection. This work was supported by a grant from the Istituto Superiore Sanità (AIDS project 40B.64 and 40A.67), CNR (Target project Biotechnology No. 99.00216.PF31 and No. 99.00401. PF49) and MURST (Rome, Italy).
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical prospecting 42 (1994), S. 0 
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: Knowledge of the declination and inclination of the total and induced magnetization vectors is normally required for the interpretation and analysis of magnetic anomalies. A new method of estimating the direction of the total magnetization vector of magnetized rocks from magnetic anomalies is proposed. The unknown declination and inclination (D*T and I*T) can be found by applying a reduction-to-the-pole operator to the measured anomalies for different couples of total magnetization direction parameters (DT and IT) and by observing the variation of the anomaly minimum as a function of both DT and I*T.and D*T are estimated using the maximum of this function. Comparing our method to previous methods, one advantage is that our estimates are not zero-level dependent; furthermore, the method allows inclinations to be well estimated, with the same accuracy as declinations; finally declinations are not underestimated. Our method is applied to a real case and meaningful results are obtained; it is shown that the feasibility of the method is improved by removing the low-frequency components.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    9600 Garsington Road , Oxford OX4 2XG , UK . : Blackwell Publishing Ltd.
    Geophysical prospecting 51 (2003), S. 0 
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: The problem of removing directional trends frequently occurs in the processing of magnetic data and also in the subsequent steps of data interpretation. The so-called corrugations are typical directional trends occurring in levelled data, which may be removed in several ways. Classical techniques are based on high-pass filtering of the data and successively filtering these transformed data with directional cosine filters. Other linear features are due to real sources, such as pipelines in shallow surveys or dike swarms in regional surveys. They should, nevertheless, be considered as noise, due to the fact that their effect is strong and tends to hide the field features related to structures of more interest. We deal with both kinds of problem, presenting the results of a study in an archaeological area of southern Italy. Decorrugation of magnetic field anomalies is performed using a method based on the excellent space–frequency localization properties of wavelet bases, allowing a very sharp filtering of the field along a selected direction. We compare this technique with the classical one in a synthetic case and find that the wavelet decorrugation is simpler and produces low distortion maps. Besides the field decorrugation, the wavelet approach was also shown to be useful in the subsequent enhancement of the measured field. In fact, we show that the wavelet analysis offers a unique framework where various filtering problems (directional, isotropic, global or local as well) may be easily solved. As regards the archaeological case, strong noisy effects from elongated sources (pipelines) were successfully removed in a sharp and local way.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-6903
    Keywords: Anaphylaxis ; atherosclerosis ; heart ; histamine ; leukotrienes ; mast cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Human mast cells, by elaborating various cytokines, chemokines and proinflammatory mediators play a complex role in several allergic and inflammatory disorders. Mast cells have been identified in human heart tissue in close proximity to the sarcolemma, in perivascular and adventitial locations and in the shoulder region of coronary atheroma. Human heart mast cells (HHMC) can be isolated from patients undergoing heart transplantation and can be immunologically activated in vitro to induce the release of tryptase, chymase, cysteinyl leukotriene C4 and prostaglandin D2. Several cytokines (e.g., stem cell factor and TNF-α) reside in secretory granules of HHMC. Mast cell density is increased in the hearts of patients with ischemic and idiopathic dilated cardiomyopathy. Cardiac mast cells might contribute to the evolution of atherosclerosis, dilated cardiomyopathy, cardiac and systemic anaphylaxis through the release of cytokines and vasoactive and proinflammatory mediators.
    Type of Medium: Electronic Resource
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