ISSN:
1569-8041
Keywords:
index
;
lymphoma
;
low grade
;
prognostic factors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Background: The International Prognostic Index (IPI) is widely usedto predict outcome of patients with aggressive lymphomas. Our goal was toassess the prognostic value of this index for low-grade lymphoma. Patients and methods: One hundred eighty-two patients withdisseminated (stage III or IV) low-grade lymphoma were enrolled in aprospective multicenter trial. According to the initial features, treatmenteither was started immediately or was deferred until indicated by diseaseprogression. Patients received the same polychemotherapy regimen, givenmonthly for six cycles. They were assigned to one of four risk groupsaccording to the number of presenting risk factors: low-risk (0 or 1),low-intermediate-risk (2), high-intermediate-risk (3), high-risk groups (4). Results: Survival curves (Kaplan–Meier method) demonstrated ahigh significant difference for the four groups (log-rank: P 〈0.0001). Median survival for the low-risk group has yet to be reached, whilethat for the three other groups are, respectively, 65, 34, and 12 months. Conclusions: In this study, the IPI has been found to be an importantprognostic tool in low-grade lymphoma and may be used in the selection ofappropriate therapeutic approaches for individual patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008297632358
Permalink