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  • 1
    Electronic Resource
    Electronic Resource
    Blood histamine and plasma histaminase level during human pregnancy (1977)
    Springer
    Inflammation research 7 (1977), S. 112-112 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion There is a negative relationship between blood histamine and plasma histaminase level [3].
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964898
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  • 2
    Electronic Resource
    Electronic Resource
    A comparison of single-dose oral fluconazole with 3-day intravaginal clotrimazole in the treatment of vaginal candidiasis (1989)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 96 (1989), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. A total of 369 women with clinical and mycological evidence of vaginal candidiasis received treatment, after random allocation, with either a single oral 150-mg dose of fluconazole (188 women) or 200 mg of intravaginal clotrimazole given daily for 3 consecutive days (181 women). They were assessed at 5–16 days and again at 27–62 days after treatment. Candida species were completely eradicated from the vagina in 72% of the fluconazole group and in 62% of the clotrimazole group at the long-term assessment (P=0·07). Favourable clinical responses were obtained in 99% of the fluconazole group and in 97% of the clotrimazole group at the short-term assessment and in 93% and 84% respectively at the long-term assessment when there was a significant advantage for fluconazole treatment (P=0·02). Symptoms in patients receiving fluconazole were relieved more rapidly (P〈0·001). Treatment-related side-effects were few and minor in both groups. It is concluded that treatment of vaginal candidiasis with fluconazole, as a single oral dose, was more effective in the long term, relieved symptoms more rapidly, and was as safe as treatment with intravaginal clotrimazole.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1989.tb01667.x
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  • 3
    Electronic Resource
    Electronic Resource
    Loop formation and synaptic adjustment in a human male heterozygous for two pericentric inversions (1986)
    Springer
    Chromosoma 93 (1986), S. 313-320 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Pachytene analysis was undertaken in an infertile male heterozygous for two pericentric inversions of chromosomes 1 and 9. The synaptic behaviour of the bivalent 1 inversion was the most informative. Analysis of the chromomere pattern combined with centromeric heterochromatin staining allowed precise description of synaptic initiation and extension leading to the homosynapsed loop. These techniques also allowed demonstration of the existence of heterosynapsis following alignment of the inverted segments. Non-homologous synapsed bivalents had the morphological aspects of straight bivalents with two distant blocks of centromeric heterochromatin. The numbering of the autosomal bivalent chromomeres at various successive phases of the inversion loop behaviour of bivalent 1 permitted us an alternative approach to the timing of pachytene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327589
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  • 4
    Electronic Resource
    Electronic Resource
    Transperitoneal laparoscopic pelvic lymphadenectomy for gynecologic malignancies (I) (1998)
    Springer
    Surgical endoscopy and other interventional techniques 12 (1998), S. 1-6 
    Details
    ISSN: 1432-2218
    Keywords: Key words: Gynecology — Gynecologic cancer — Laparascopic pelvic lymphadenectomy — Lymph nodes — Laparotomy — Cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: We reviewed the published experimental and clinical data, available in MEDLINE, and compared them to our experience in a university-affiliated tertiary medical center of obstetrics and gynecology in order to describe the accepted techniques and results of laparoscopic pelvic lymphadenectomy. Methods: The procedure requires a four-port access laparoscopy. Dissection boundaries are similar to those for open surgery. Results: Experimental and clinical comparative series have shown that the number of harvested lymph nodes is not significantly different for laparoscopy than for laparotomy. Several authors reported a learning curve, reflecting the surgeon's increasing accuracy with growing operative experience. Obesity and prior history of laparotomy are both factors that impact adversely on the number of nodes harvested and the complication rate. Otherwise, the number of residual nodes is similar for the two approaches. In both cases, it is low, resulting in a high sensitivity (95–100%). The complication rate is directly linked to the surgeon's experience and thus appears low for skilled laparoscopic operators. It is similar to that reported for open surgery. Anesthesiological complications have not been well assessed in the literature on laparoscopic lymphadenectomy. Operating time was longer than for laparotomy in all the series. Conversely, mean blood loss, duration of hospitalization, and recovery time were significantly decreased. Although intraoperative cost of the laparoscopic procedure is high in comparison with laparotomy, since the time of recovery appears shorter, total costs may be similar or even lower. Conclusion: We conclude that laparoscopic pelvic lymphadenectomy is a reliable and safe procedure for the evaluation and treatment of gynecologic cancers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004649900582
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  • 5
    Electronic Resource
    Electronic Resource
    Morbidity in laparoscopic gynecological surgery (1999)
    Springer
    Surgical endoscopy and other interventional techniques 13 (1999), S. 57-61 
    Details
    ISSN: 1432-2218
    Keywords: Key words: Laparoscopy — Complications — Gynecological surgery — Prospective study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: We set out to investigate prospectively the morbidity rate for gynecological laparoscopy patients at a tertiary care center. Methods: We prospectively recorded data on 743 laparoscopic procedures performed between January 1, 1992 and December 31, 1996. The procedures included 36 diagnostic laparoscopies (4.8%), 115 laparoscopies carried out for minor surgical acts (15.4%), 523 for major surgical acts (70.4%), and 69 for advanced surgical acts (9.4%). A total of 127 patients had a history of prior laparotomy (17%). All those procedures were performed by young senior surgeons. We defined a complication as an event that had modified the usual course of the procedure or of the postoperative period. For statistical analysis, we used the chi-squared test or Fisher's exact test. Results: Complications occurred in 22 cases; the overall complication rate was 2.9% when all events were considered. One complication (injury of the left primitive iliac artery) was related to insertion of the Veress needle (0.13%). A total of 2,578 trocars were inserted, giving rise to 10 complications (1.3%). Three unintended laparotomies were required for bowel or bladder injuries (0.4%). Finally, the introduction of the laparoscope was responsible for 11 complications (1.4%); this figure represents 50% of all the complications of this series. Eight intraoperative complications (1%) occurred during the laparoscopic surgery (seven severe bleedings and one ureter injury, but no intestinal lesions); laparotomy was required in six of these cases. Three complications occurred during the postoperative stage: one granulomatous peritonitis after intraabdominal rupture of a dermoid cyst, one incisional hernia, and a fast-resolving cardiac arrhythmia. Conclusions: In our experience, operative gynecological laparoscopy is associated with an acceptable morbidity rate. Moreover, about half of the complications occur during the installation of the laparoscopic procedure, underscoring the usefulness of safety rules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004649900898
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  • 6
    Electronic Resource
    Electronic Resource
    Transperitoneal laparoscopic pelvic lymphadenectomy for gynecologic malignancies (II) (1998)
    Springer
    Surgical endoscopy and other interventional techniques 12 (1998), S. 97-100 
    Details
    ISSN: 1432-2218
    Keywords: Key words: Lymphadenectomy — Cervical cancer — Endometrial cancer — Ovarian cancer — Gynecologic malignancy — Adverse effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: We reviewed the published experimental and clinical data, available in MEDLINE, and compared them with our own experience, in a university-affiliated tertiary medical center of obstetrics and gynecology in order to report on the accepted indications for laparoscopic pelvic lymphadenectomy. Methods: Surgical staging of cervical carcinoma can be performed via the laparoscopic approach. Intraperitoneal biopsies, washings, and pelvic lymphadenectomy can also be carried out with high accuracy and limited morbidity. Node-negative women are better treated by a radical hysterectomy performed either simultaneously (using frozen sections) or secondarily after routine pathologic examination of the pelvic nodes. Node-positive patients have a poor prognosis, no matter what the treatment is, and are generally considered for radiotherapy and/or chemotherapy. The use of laparoscopic pelvic lymphadenectomy in advanced cervical cancers is limited. Results: Laparoscopy has a direct therapeutic application in endometrial carcinoma. Total hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymphadenectomy can all be performed via laparoscopy. Thus, stage I and some stage II endometrial cancers can be treated exclusively laparoscopically. This approach seems as effective as laparotomy, but it dramatically reduces the costs and morbidity associated with conventional treatment. Conclusions: Currently, the use of laparoscopy in ovarian and tubal cancers is confined to referral centers. Laparoscopy appears to be as effective as laparotomy for second-look surgery. Treatment of stage II and more advanced ovarian cancers has been reported, but it cannot be recommended in a routine situation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004649900606
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