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  • 1
    Electronic Resource
    Electronic Resource
    Effects of indole-3-acetic acid on croton oil- and arachidonic acid-induced mouse ear edema (1995)
    Springer
    Inflammation research 44 (1995), S. 372-375 
    Details
    ISSN: 1420-908X
    Keywords: Indole-3-acetic acid ; Mouse ear edema ; Antioxidants ; Croton oil ; Arachidonic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The indole-3-acetic acid (IAA) is a plant growth hormone (auxin) being considered as a tryptophan metabolite in animals. The main purpose of this work was to verify IAA's topical anti-inflammatory action using croton oil- or arachidonic acid-induced mouse ear edema, in comparison to known anti-inflammatory agents. IAA antioxidant activity was also verified by measuring the inhibition of brain homogenate lipid peroxidation with the thiobarbituric acid reactive substances (TBARS) test. IAA inhibited the action of both croton oil- and arachidonic acid-induced edema in a dose-dependent manner (4.0 µmoles IAA inhibited 75.8% in croton oil and 82.5% in arachidonic acid induced ear edema). Both IAA (5.3 mM) and indomethacin (8.0 mM) inhibited TBARS formation. Data suggest that IAA exhibits antiinflammatory effect possibly by its antioxidant activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01797863
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    In vitro inactivation of the neurotoxic action of β-bungarotoxin by the marine natural product, manoalide (1984)
    Springer
    Cellular and molecular life sciences 40 (1984), S. 864-865 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The irreversible neurotoxic action of β-bungarotoxin (β-BuTx) can be prevented by preincubation of the toxin with manoalide, a non-steroidal anti-inflammatory agent. Manoalide was also found to inactivate purified phospholipase A2 and thus prevent hydrolysis of phosphatidylcholine. PLA2 is a component found in several neurotoxic venoms and is also a rate limiting enzyme important in phospholipid metabolism and prostaglandin synthesis in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951998
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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