Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 39 (1983), S. 272-280 
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 24 (1983), S. 807-812 
    ISSN: 1432-1041
    Keywords: serum digoxin ; erythrocyte ghosts ; Na+,K+-ATPase inhibition ; digoxin-receptor interaction ; chronic digoxin therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Digoxin therapy has been made more rational by the measurement of serum digoxin concentrations. However, difficulties remain because of the overlap between “therapeutic” and “toxic” serum concentrations and the lack of an obvious therapeutic endpoint in many patients. An assay which measures the degree of interaction between digoxin and its putative receptor, the membrane Na+, K+-ATPase, might be capable of resolving some of these difficulties. Therefore, as a first approach in this direction we evaluated the relationship between serum digoxin concentration and the degree of inhibition of RBC ghost Na+, K+-ATPase activity in patients receiving digoxin therapy. Utilizing an improved micro-assay technique, Na+, K+-ATPase activity was determined in aliquots of RBC ghosts before and after removal of bound digoxin. In 27 patients a significant relationship was present between serum digoxin concentration and the degree of RBC ghost Na+,K+-ATPase inhibition. However, at any serum digoxin concentration, there was a variation in the magnitude of enzyme inhibition from patient to patient. This study confirms the feasibility of determining the degree of in vivo RBC Na+,K+-ATPase inhibition in man and demonstrates, for the first time, a highly significant but somewhat variable relationship between serum digoxin concentrations and the magnitude of RBC digoxin receptor inactivation. This quantitative, functional, individualized assay of digoxin effects may prove to be of clinical value in the future.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 16 (1978), S. 531-536 
    ISSN: 1741-0444
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Description / Table of Contents: Sommaire Le but de cette étude est de déterminer la sensibilité de l'impédance électrique de la cage thoracique aux changements du volume sanguin dans différentes régions du thorax. Pour cela, le sang de chiens récemment sacrifiés a été infusé de manière variable à la fois par étapes et en continu dans les ventricules, oreillettes, poumons et également dans des segments isolés de l'aorte. Les résultats montrent que les sensibilités de l'impédance aux changements de volume dans les oreillettes et l'aorte sont similaires, tandis que les changements de volume dans les ventricules sont nettement moins d'effet. Des pulsations de sang de volume égal dans les poumons ou l'aorte donnent un changement d'impédance d'amplitude similaire, mais une estimation basée sur les changements de pression de contrôle indique que l'effet des changements de volume sanguin dans l'aorte modifie l'impédance de moins de 30%. Ces données montrent donc que des changements de volume de plusieurs des structures cardiovasculaires intrathrocaques participent probablement à la création d'un changement d'impédance électrique cardiaque composite.
    Abstract: Zusammenfassung Der Zweck dieser Studie war, die Sensibilität der brustkorbbezüglichen elektrischen Impedanzveränderung auf Blutvolumenveränderungen in verschiedenen Regionen des Brustkorbs zu bestimmen. Bei kurz zuvor euthanasierten Hunden wurde Blut sowohl schrittweise als auch in kontinuierlicher Form abwechselnd in die Hirnkammern, Atria, Lungen und isolierte Segmente der Aorta infusiert. Die Resultate zeigen, daß die Impedanzsensibilität in bezug auf die Volumenveränderungen in Atria und Aorta in beiden ähnlich ist, während die Volumensveränderungen der Hirnkammern eine bedeutend kleinere Wirkung zeigten. Gleiche Blutvolumenimpulse in Lunge oder Aorta erzeugen eine ähnlich große Impedanzveränderung, jedoch weisen auf Regeldruckveränderungen basierende Schätzungen darauf hin, daß die Wirkung der Aorta-Volumenveränderung auf die Impedanz kleiner als 30% ist. Deshalb sind die Daten eine Indikation dafür, daß Volumenveränderungen verschiedener intrathorakischer herzgefäßbezüglicher Strukturen möglicherweise zur Erzeugung einer zusammengesetzten kardiogenen elektrischen Impedanzveränderung beitragen.
    Notes: Abstract The purpose of this study was to determine the sensitivity of the thoracic electrical impedance change to blood-volume changes in various regions of the thorax. Using recently euthanatised dogs blood was infused in both a stepwise and a continuously varying manner into the ventricles, atria, lungs and isolated segments of the aorta. The results show that the impedance sensitivities to volume changes in the atria and aorta are similar, whereas the volume changes of the ventricles showed a significantly smaller effect. Equal blood-volume pulses into the lungs or aorta cause an impedance change of a similar magnitude, but estimates based on control-pressure changes indicate the effect of aorta volume change on the impedance to be less than 30%. The data, therefore, indicate that changes in volume of several of the intrathoracic cardiovascular structures are likely to be involved in the generation of a composite cardiogenic electrical impedance change.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...