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  • 1
    Electronic Resource
    Electronic Resource
    Inhibitory effect of cold stress on lung tumours induced by 7,12-dimethylbenz[a]anthracene in mice (1995)
    Springer
    Journal of cancer research and clinical oncology 121 (1995), S. 393-396 
    Details
    ISSN: 1432-1335
    Keywords: Cold stress ; Glutathione ; Lung tumour ; 7,12-Dimethylbenz[a]anthracene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of cold stress on lung tumours induced by 7,12-dimethylbenz[a]anthracene (DMBA) was investigated in ICR male and female mice. When mice were exposed to cold stress at 0±1°C for 2 h, three times per week (every other day) for 3 months, the rectal temperatures and hepatic glutathione levels were significantly decreased. On the other hand, when DMBA (10 mg/kg) was subcutaneously injected into neonatal mice, lung tumours were observed in 81.8% of non-stressed mice of both sexes 4 months after injection. However, when mice treated with the same dose of DMBA were exposed to cold stress under the same conditions, lung tumours were observed in 53.3% and 30.3% of the male and female mice 4 months after DMBA injection. In addition, although DMBA (1 mg/kg) caused lung tumours in 20% or 40% of the treated male or female mice 4 months after injection, it did not cause lung tumours in all of the male and female mice exposed to cold stress. These results suggest that cold stress may inhibit lung tumours induced by chemicals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01212944
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Genetic analysis of human lymphocyte proteins by two-dimensional gel electrophoresis: 2. Genetic polymorphism of lymphocyte cytosol 64K polypeptide (1982)
    Springer
    Human genetics 〈Berlin〉 60 (1982), S. 176-180 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We describe a genetic polymorphism of human lymphocyte cytosol major polypeptide with mol. wt. 64,000, detected in peripheral blood lymphocytes by high resolution two-dimensional electrophoresis. Three different electrophoretic types (1-1, 2-1, 2-2) of the polypeptide have been identified. Family and population studies indicate that the three phenotypes of the polypeptide are determined by two common alleles at a single autosomal locus. The polypeptide occurs in the cytosol and is predominent in peripheral blood lymphocytes, B-lymphoblastoid cells, T-lymphoblastoid cells, lymph node, and spleen. The polypeptide has not been detected in HeLa cells, fibroblasts, erythrocytes, serum, and cerebrum. Traces of the polypeptide exist in liver, kidney, and skeletal muscle. It is proposed that the polypeptide and its locus be temporarily designated lymphocyte cytosol 64K polypeptide (LC64K polypeptide) andLC64P, respectively. In a Japanese population, the gene frequencies ofLC64P 1 andLC64P 2 were 0.936 and 0.064, respectively. The data suggest thatLC64P is a new locus, product of which shows genetic polymorphism and is associated with the function and/or the structure of lymphocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00569708
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Venous tumor thrombosis and cavernous transformation of the portal vein in a patient with gastric carcinoma (1995)
    Springer
    Journal of gastroenterology 30 (1995), S. 529-533 
    Details
    ISSN: 1435-5922
    Keywords: tumor thrombosis ; portal vein ; gastric carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of extensive extra-and intrahepatic portal tumor thrombosis, with no metastatic foci in liver parenchyma, secondary to advanced gastric carcinoma in a 69-year-old man is reported. The portal tumor thrombosis was characterized by enlargement of the thrombosed segment of the vein, decreased density mass without intraluminal enhancement of the involved vein, nonvisualization of the portal venous branch in the involved lobe, and the so-called cavernous transformation of the portal vein. The surgically resected gastric specimen showed Borrmann type 3 advanced papillary adenocarcinoma. The portal tumor thrombus is presumed to have arisen from vascular invasion in the primary foci of gastric carcinoma, and then to have permeated the portal vein without invasion of liver parenchyma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02347573
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Primary tubular adenocarcinoma arising in the duodenal limb of reconstructed gastroduodenostomy for signet-ring cell carcinoma of the stomach (1995)
    Springer
    Journal of gastroenterology 30 (1995), S. 657-660 
    Details
    ISSN: 1435-5922
    Keywords: duodenal cancer ; gastric cancer ; metachronous cancer ; adenocarcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Adenocarcinoma of the small intestine is uncommon. Due to this paucity and the lack of specificity of symptoms, patients are usually seen late in the course of their illness, when curative therapy, mainly represented by extensive surgical resection, is unlikely. The authors report a case of primary well-differentiated tubular adenocarcinoma (T4N0M0) arising in the duodenal limb of a reconstructed Billroth I gastroduodenostomy, 9 years after a distal gastrectomy for signet-ring cell carcinoma of the stomach (T4N0M0). Evidence for excluding the possibility of a recurrence of the primary gastric cancer was based on the different histologic pattern, the long disease-free interval, and other features of the second neoplasm. Relatively early diagnosis of the neoplasm, followed by curative surgical therapy was made possible by the early onset of the obstructive symptoms and the favorable anatomical location of the tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02367794
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    Paper (German National Licenses)
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