ISSN:
1435-1803
Keywords:
age
;
myocardium
;
actomyosin
;
ATPase activity
;
sulfhydryl groups
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Cardiac ventricular actomyosin was prepared from autopsy samples from humans ranging in age from one to 83 years, and its Ca2+-ATPase and K+-EDTA-ATPase activities were determined in the presence or absence of a sulfhydryl reagnet, N-ethylmaleimide (NEM). The Ca2+-ATPase activity increased in the presence of appropriate concentrations of NEM. The extent of the stimulation of Ca2+-ATPase activity by NEM decreased significantly with age. The ratio of K+-EDTA-ATPase activity to Ca2+-ATPase activity also decreased with age. This suggests that there is an age-related modification of sulfhydryl groups in the myosin molecule.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01907009
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