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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacological action of FPL 55712 on canine cerebral arterial segments (1985)
    Springer
    Acta neurochirurgica 74 (1985), S. 81-83 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pharmacological action of a leukotriene antagonist FPL 55712 was studied on canine cerebral arterial segments. FPL 55712 at concentrations of 10−6M and 10−5M showed dosedependent inhibition of the constrictor responses of the artery to prostaglandin F2α. The constrictor responses of the artery to either serotonin or haemoglobin were suppressed by 10−5M FPL 55712, while 10−6M FPL 55712 failed to alter the responses. The KCL-induced constriction was not affected by treatment with either 10−6M or 10−5M FPL 55712. The present results suggest that FPL 55712 has vasodilator properties other than those related to the inhibition of leukotrienes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01413283
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of hypoxia on endothelium-dependent relaxation of canine and rabbit basilar arteries (1989)
    Springer
    Acta neurochirurgica 97 (1989), S. 77-82 
    Details
    ISSN: 0942-0940
    Keywords: Endothelium-dependent relaxation ; hypoxia ; subarachnoid haemorrhage ; vasospasm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An important role of endothelium-dependent relaxation in the local regulation of vascular tone has been suggested. In the present study, the effect of hypoxia on endothelium-dependent relaxation was investigated in canine and rabbit basilar and in rabbit common carotid arteriesin vitro, using an isometric tension recording method. Hypoxia was introduced by changing the gas mixture in thein vitro chamber from 95% O2-5% CO2 to 95% N2-5% CO2. Thrombin and acetylcholine were used to induce endothelium-dependent relaxation. Thrombin at 0.1 and 1.0U/ml, respectively, caused dose-dependent relaxation of the canine basilar artery precontracted by 10−6M prostaglandin F2α. Acetylcholine also evoked dose-dependent relaxation of rabbit basilar and common carotid arteries precontracted by serotonin. Under hypoxic conditions, the relaxing effect of thrombin or acetylcholine decreased both in canine and in rabbit arteries, although it was not significant in rabbit basilar arteries. It has been postulated that following subarachnoid haemorrhage, diffusion of oxygen to the walls of the major cerebral arteries might be impaired by the subarachnoid clot. This could cause hypoxia of the arteries and contribute to vasospasm by suppressing endothelium-dependent relaxation, as well as by enhancing the contractile responses of the cerebral arteries to the vasoconstrictor agents in the bloody cerebrospinal fluid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01577744
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    De novo aneurysm formation and aneurysm growth following therapeutic carotid occlusion for intracranial internal carotid artery (ICA) aneurysms (1993)
    Springer
    Acta neurochirurgica 120 (1993), S. 20-25 
    Details
    ISSN: 0942-0940
    Keywords: Aneurysm surgery ; trapping ; carotid ligation ; late results ; new aneurysm formation ; secondary enlargement ; rebleeding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We herein report the long term results of 27 intracranial internal carotid artery (ICA) aneurysms treated by indirect surgery such as a trapping of the aneurysm or carotid ligation either with or without EC-IC bypass. These patients were then followed for a mean period of 10 years. Seventy-four percent of the aneurysms were categorized as either being giant or large. Late complications were observed in 7 patients. A rupture of newly formed aneurysms at the anterior communicating artery occurred in 2 cases 8 or 9 years after either trapping or performing a ICA ligation, respectively. In these patients, previous angiography could not reveal any abnormalities at the anterior communicating artery. A rupture of a contralateral ICA aneurysm was seen in a patient whose ipsilateral ICA was ligated for a ICA aneurysm 22 years previously. An enlargement of the contralateral giant cavernous ICA aneurysm became symptomatic 6 years after a partial ligation of the ICA combined with an EC-IC bypass for a giant cavernous carotid artery aneurysm on the other side. Two cases of sudden death occurred in a young patient and an elderly patient with a small anterior communicating artery aneurysm, 9 and 19 years respectively, after trapping of the ICA aneurysms, although the cause could not be definitely ascertained. Rebleeding occurred in one patient who died 8 years after a carotid ligation and a partial clipping of the ICA aneurysm. Haemodynamic stress may therefore play a major role in inducing new aneurysms or growing aneurysms. Careful consideration should thus be taken whenever a therapeutic carotid occlusion is selected as the treatment for carotid artery aneurysms, and a long term follow-up should be done with MR, angiography or DSA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02001464
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Repeat angiography and magnetic resonance imaging (MRI) of dissecting aneurysms of the intracranial vertebral artery (1993)
    Springer
    Acta neurochirurgica 121 (1993), S. 123-129 
    Details
    ISSN: 0942-0940
    Keywords: Dissecting aneurysm ; repeat angiography ; MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We here present 4 cases with dissecting aneurysm (DA) of the intracranial vertebral artery, who were followed up by repeat cerebral angiography and MRI. The patients consisted of 2 males and 2 females, and the mean age was 43 years. Two cases were associated with polyarteritis nodosa (PN) and hypertension, respectively. Three of the cases developed subarachnoid haemorrhage (SAH), while the other one suffered from lateral medullary syndrome. In cerebral angiography, “pearl and string” signs were revealed in all cases, while a “double lumen” indicating a true diagnostic sign of DA was demonstrated in only one case. Repeat angiography showed that a bleb formation with a bulging of the aneurysmal sac was seen in 2 cases, and an irregularity of the wall in one case. On the other hand in one case, the ectatic part shrank, while the stenotic part was restored. In magnetic resonance imaging (MRI), a hyperintensity mass on T 1-weighted image (T 1-WI) adjacent to flow void suggesting either an intramural haematoma or a linear shape hyperintensity on T1-WI were demonstrated in 3 cases. In the follow up MRI done in 2 cases, a serial change in the intensity from iso-intensity to hyperintensity on T 1-WI was observed in one case suggesting intramural haemorrhage, while an enlargement of the ectatic flow void was seen in the other case. Three of 4 cases were operated on by trapping of the aneurysms. One, who had systemic vascular diseases due to PN, and repeat angiography showed a regression of the aneurysm, was conservatively treated. The outcome was excellent in the 3 surgical cases, whilst the one medically treated case was also excellent without any rebleeding. In conclusion, repeat neuro-imaging procedures are strongly recommended to clarify the possibility of a spontaneous repair of the dissection, and to consider the surgical strategy for the lesion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01809262
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    Paper (German National Licenses)
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