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  • 1
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs ont étudié les suites opératoires de 50 malades qui avaient subi une résection hépatique en comparant les taux de rétention de l'indocyanine green (ICG) mesurés lors du 3ème jour post-opératoire par rapport à ceux appréciés immédiatement après l'opération. Ce rapport étant l'expression de l'index ICG du parenchyme restant. Le groupe A de 22 malades avec un index restant de moins de 1.0, (qui signifie le taux de rétention de ICG à 15 mm lors du 3ème jour post-opératoire) a montré une amélioration par comparaison aux faits qui ont succédé immédiatement à l'intervention. Un groupe B de 28 malades chez qui l'index au 3ème jour était supérieur à 1.0, indiquant par conséquent une élévation du taux de clarance de l'ICG après résection hépatique, a été individualisé. De sérieuses complications comprenant infection abdominale et hyperbilirubinémie se sont manifestées en post-opératoire respectivement chez 2 (9.1%) du groupe A et 16 (57.1%) du groupe B (p〈0.001). Un malade (4.5%) du groupe A décéda cependant que 9 malades (32.1%) du groupe B moururent pendant l'hospitalisation (p〈0.02). Il ne fut pas constaté de différence significative en ce qui concerne la fonction hépatique préopératoire et les paramètres cliniques. Ces observations suggèrent que l'amélioration du taux de la clairance de l'ICG au 3ème jour post-opératoire par comparaison au taux déterminé immédiatement après l'intervention permet de préjuger des suites post-opératoire après résection hépatique.
    Abstract: Resumen Hemos valorado la evolución postoperatoria de 50 pacientes sometidos a resección hepática, utilizando la relación entre las tasas de retención del verde de indocianina (VIC) medidas en el tercer día postoperatorio y los valores estimados inmediatamente después de la operación. Esta relación fue expresada en forma del indice VIC de remanente hepático. El grupo A incluyó 22 pacientes con un indice de menos de 1.0, lo cual significa que la tasa de retención VIC a los 15 minutos en el tercer día postoperatorio mostró mejoría en comparación con los hallazgos inmediatamente al término de la operación. En el grupo B hubo 28 pacientes cuyos indices en el tercer día postoperatorio fue superior a 1.0, lo cual indica exacerbación de la tasa de depuración de VIC después de la resección hepática. Se presentaron complicaciones postoperatorias graves, incluso sepsis intraabdominal e hiperbilirrubinemia en 2 (9.1%) en el grupo A y 16 (57.1%) en el grupo B (p〈0.001). Murió un paciente (4.5%) en el grupo A contra 9 pacientes (32.1%) que murieron en el grupo B en el curso de la hospitalización (p〈 0.02). No se observaron diferencias significativas en cuanto a las pruebas preoperatorias de función hepática o los parámetros clínicos. Estas observaciones sugieren que la mejoría en la tasa de depuración de VIC en el tercer día postoperatorio, comparada con aquella inmediatamente al término de la operación, es un paramétro de utilidad en la predicción del curso postoperatorio de pacientes hepatectomizados.
    Notes: Abstract We evaluated the postoperative course of 50 patients who underwent hepatic resection, using the ratio of indocyanine green (ICG) retention rates measured on the third postoperative day to values estimated immediately after the operation. This ratio was expressed as the remnant liver ICG index. Group A included 22 patients with a remnamt liver ICG index of less than 1.0, which meant that the ICG retention rate at 15 minutes on the third postoperative day showed improvement, compared to events immediately after the operation. In group B, there were 28 patients whose index on the third postoperative day was over 1.0, thereby indicating exacerbation of the ICG clearance rate after hepatic resection. Serious complications including intraabdominal sepsis and hyperbilirubinemia occurred postoperatively in 2 (9.1%) in group A and 16 (57.1%) in group B (p〈0.001). One patient (4.5%) in group A died, while 9 patients (32.1%) in group B died during hospitalization (p〈 0.02). There were no significant differences with regard to preoperative liver function and clinical parameters. These observations suggest that improvement in the ICG clearance rate on the third postoperative day, compared to that immediately after the operation, is useful to predict the postoperative course of hepatectomized patients.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-1803
    Keywords: Key words Canine – purkinje fiber – pertussis toxin – G protein – autonomic modulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It has been reported that acetylcholine hyperpolarizes the maximum diastolic potential of canine Purkinje fibers through a pathway involving a G protein and induces a decrease in their automaticity. It is unclear, however, whether the negative chronotropic action of acetylcholine in the presence of β-adrenergic stimulation is due to the hyperpolarization of the maximum diastolic potential or a decrease in the slope of phase 4 depolarization. We used standard microelectrode techniques to study the negative chronotropic mechanism of acetylcholine in the presence of isoproterenol in adult canine Purkinje fibers. Fibers were incubated for 24 hours in Tyrode's solution alone (n = 10) or plus pertussis toxin (n = 10), and then superfused with acetylcholine (10−9 to 10−4 M) in the presence of isoproterenol (10−7 M). Acetylcholine in the presence of isoproterenol significantly decreased automaticity without hyperpolarization of the maximum diastolic potential, and decreased the slope of phase 4 depolarization. Th effects of acetylcholine on automaticity and the slope of phase 4 depolarization were attenuated by pertussis toxin. The present findings indicate that the negative chronotropic action of acetylcholine in the presence of isoproterenol is due to the decrease in the slope of phase 4 depolarization through a pathway involving a pertussis toxin-sensitive G protein and that it is not the result of hyperpolarization of the maximum diastolic potential.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Surgery today 13 (1983), S. 32-36 
    ISSN: 1436-2813
    Keywords: small liver cancer ; early detection ; diagnostic sensitivity ; operative management
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report eight cirrhotic patients with liver cancer of less than 2 cm in diameter, and who were successfully treated by surgery. The sensitivities of diagnostic procedures for small lesions showed that alpha-fetoprotein (AFP) was 75 per cent, radionuclide scanning 25 per cent, CT 33 per cent, ultrasonography 40 per cent and angiography 88 per cent. Serial measurement of AFP appears to be the most helpful for detection of hepatocellular carcinoma at the early stage, particularly in cirrhotic patients. Although hepatic imagings are of limited value for small hepatic tumors, those tools are often useful as a back-up for the routine tests but not for initial procedures. It should also be kept in mind that hepatic arteriography performed in the high risk group often leads to detection of small cancers. In cirrhotic patients with small hepatocellular carcinoma, surgical resection should be done, providing the clinical status and hepatocellular reserve are adequate.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1436-2813
    Keywords: Lipiodol Ultra-Fluid ; Doxorubicin ; Urografin ; selective cancer chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twelve-day-old VX2 carcinoma was inoculated in the hind leg of 24 rabbits and, after 12 days, Doxorubicin (Adriamycin) suspended in Lipiodol Ultra-Fluid (Lipiodol) was then given through the femoral artery. A selective deposit of the contrast material in the tumor for an extended time was evident on the x-rays and the antitumorous effect was remarkable. Lipiodolized antitumor agents warrant further investigation for possible clinical application.
    Type of Medium: Electronic Resource
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