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  • 1
    Electronic Resource
    Electronic Resource
    Human cystic kidney diseases: epithelial hyperplasia in the pathogenesis of cysts and tumors (1987)
    Springer
    Pediatric nephrology 1 (1987), S. 393-396 
    Details
    ISSN: 1432-198X
    Keywords: Polycystic kidney disease ; Renal carcinoma ; Tuberous sclerosis ; von Hippel-Lindau disease ; Acquired renal cystic disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Several examples of human renal cystic disease are associated with tubular epithelial hyperplasia. Micropapillary hyperplasia occurs in autosomal dominant polycystic kidney disease, in localized cystic disease, and in acquired cystic disease; neoplastic or severely dysplastic epithelial hyperplasia occurs in von Hippel-Lindau disease; a histopathologically distinctive epithelial hyperplasia occurs in tuberous sclerosis. In all of these conditions the epithelial hyperplasia appears to be responsible for cyst formation by causing tubular or ductal luminal obstruction, and in all of these conditions, save localized cystic disease (a rare condition with very few reported cases), epithelial hyperplasia imposes an increased risk of malignancy. The risk seems to be highest in patients under treatment with long-term hemodialysis for end-stage kidney disease. Some of these diseases may share common features, but it appears likely that the histopathological differences reflect different features converging on a common result.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00849242
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Detection of Serum Proteins within the Renal Collecting Tubule Cells of the Potassiurn-deficient Rat (1961)
    [s.l.] : Nature Publishing Group
    Nature 190 (1961), S. 96-97 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Solutions of T-1824, kindly presented by the Warner-Chilcott Laboratories, New York, were injected into the tail veins of twelve 200-gm. male Wistar rats (5 mgm./lOO gm. body-weight of the rat) that had been made potassium-deficient by feeding for three weeks on a diet deficient in potassium. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/190096a0
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  • 3
    Electronic Resource
    Electronic Resource
    MDCK cysts: An in vitro model of epithelial cyst formation and growth (1986)
    Springer
    Methods in cell science 10 (1986), S. 245-248 
    Details
    ISSN: 1573-0603
    Keywords: MDCK cell ; renal cell culture ; epithelial cysts ; collagen gel ; clonal growth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary MDCK cells dissociated from monolayer culture were either dispersed within medium-hydrated collagen gel or seeded atop a collagen substrate which was immediately overlaid with collagen gel. Individual cells exhibited clonal growth in three dimensions to form spherical cysts in which a simple epithelium surrounded a fluid-filled lumen. The cells of MDCK cysts were polarized with apical surface bordering the lumen. MDCK cysts increased in diameter with continued culture. Maximum cyst size was dependent on seeding density and was influenced by medium composition. MDCK cysts could be isolated from the collagen substrate by digestion with collagenase. Also, collagen gel could be dissected from the cyst wall to give unrestricted access to regions of the basolateral cell surface. This novel method of renal cell culture provides a study system to model the influence of the extracellular matrix on kidney epithelial cell structure and function. It also offers an in vitro model of general application to the study of epithelial cyst formation and growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01404485
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  • 4
    Electronic Resource
    Electronic Resource
    Morphogenetic clonal growth of kidney epithelial cell line MDCK (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 217 (1987), S. 229-239 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: MDCK (Madin-Darby canine kidney) cells were cultured either (1) dispersed within hydrated collagen gel (HCG) or (2) seeded atop a collagen substrate and then immediately overlaid with HCG. Individual cells exhibited clonal growth in three dimensions to form spherical cysts made up of a simple epithelium enclosing a fluid-filled lumen. The cells of MDCK cysts were polarized with the basolateral surface in contact with the collagen gel and the apical surface bordering the lumen. The ultrastructure of MDCK cysts showed similarities to distal nephron. The cells bore apical microvilli and solitary cilia and had occluding junctions and a simple basolateral surface. MDCK cysts increased in size (〉 800 μm diameter) with continued culture. MDCK cysts grown between layers of HCG were stripped free of the overlying collagen to give direct access to basolateral surface membrane. Unlike monolayer culture, morphogenetic clonal growth of cell line MDCK produces a polarized cell population with a true lumenal and basolateral surface. Collagen-gel-cultured MDCK cysts provide an easily manipulable in vitro cell system that may offer unique advantages for the study of renal cell structure and function.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092170303
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    Paper (German National Licenses)
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