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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillan Magazines Ltd.
    Nature 395 (1998), S. 216-217 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Dame Kathleen Ollerenshaw, one of Englan's national treasures, has solved a long-standing, extremely difficult problem involving the construction and enumeration of a certain type of magic square. The solution comes in a book*written with David Brée. First, some background on ...
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 385 (1997), S. 405-406 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Recent decades have seen an astonishing upsurge of popular infatuation with fringe science and the paranormal. A hundred years ago, no newspaper in the United States carried a horoscope. Today almost every paper except The New York Times has such a feature. A recent US president and his wife, ...
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1542-474X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Left (LBBB) and right (RBBB) bundle branch block (BBB) patients have an increased incidence of cardiac death after myocardial infarction (Ml). The purpose of this study was to assess the value of the signal-averaged electrocardiogram (SAECG) and other clinical variables for the prediction of cardiac death after MI in BBB patients.〈section xml:id="abs1-2"〉〈title type="main"〉MethodsSAECGs were recorded 5–15 days after MI in 76 LBBB and 79 RBBB patients. The SAECG was analyzed in the time domain and the frequency domain (wavelet analysis in 7 frequency bands ranging from 0.05 to 250 Hz).〈section xml:id="abs1-3"〉〈title type="main"〉ResultsDuring follow-up (17 ± 8 months), cardiac death occurred in 22 LBBB (28.9%) and 12 RBBB patients (15.2%). None of the SAECG time-domain variables were significantly different between patients with and without cardiac death. In LBBB patients, univariate analysis showed that one wavelet parameter in the 3.9- to 7.8- Hz frequency band (P = 0.008), inhospital recurrent Ml (P = 0.002), left ventricular ejection fraction (LVEF) 〈 30% (P = 0.004), lack of percutaneous transluminal coronary angioplasty (P = 0.02), and history of angina (P = 0.029) were significantly different in cardiac death patients. In RBBB patients, only recurrent angina was significantly different (P = 0.025). In LBBB patients, the combination of recurrent Ml or LVEF 〈 30% displayed the best predictive values: sensitivity (85.7%), specificity (76.6%), positive (52.2%), negative (94.7%), and total (78.7%) predictive accuracies and risk ratio of 9.9. The effect of recurrent Ml and LVEF 〈 30% remained after statistical adjustment by means of regression using Cox proportional hazards.〈section xml:id="abs1-4"〉〈title type="main"〉ConclusionsHigh-risk Ml patients can be identified by recurrent Ml and LVEF 〈 30% in LBBB patients, and by recurrent angina in RBBB patients. SAECG did not demonstrate incremental information for the purpose of risk stratification in BBB patients.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Pacing and clinical electrophysiology 22 (1999), S. 0 
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Magnetic field maps and body surface potential maps can be used to measure cardiac activity. The ability of magnetic and potential body surface maps to identify patients' vulnerable to recurrent sustained ventricular arrhythmia (VA) were compared. Magnetic field maps (MFM) and body surface potential mapping (BSPM) were obtained from 76 normal (N) subjects, 15 myocardial infarct (MI) patients, and 15 VA patients. QRST integral maps were calculated for each subject and nondipolar content was determined using Karhunen-Loeve transform eigen-maps. Although differences in nondipolar content were significant between the normal and patient groups (P = 2.4 × 10−5 for BSPM and P = 6.0 × 10−8 for MFM), differences in nondipolar content between MI and VA patients using QRST integral BSPM and MFM maps were not significant. The trajectory of the location of the maxima and minima on the map area during the QRS and ST-T intervals were also constructed. Discrimination between MI and VA patients was based on intergroup differences in the amount of fragmentation of the trajectory plots. The ST-T trajectory plots were significantly more fragmented (P 〈 0.0001 and P 〈 0.05 for MFM and BSPM, respectively) for VA than for MI patients. The ST-T interval MFM and BSPM trajectory plots enabled separation of MI and VA patients with accuracies of 83% and 73%, respectively. These results suggest that repolarization MFM and BSPM extrema trajectory plots can be used effectively as a means of identifying patients at risk for VA.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Unilateral Stellate Block. Introduction: Left sided stellate ganglion predominance has been proposed as a mechanism responsible for lethal ventricular arrhythmias, due to hetaerae nouns ventricular repolarization. To determine the cardiovascular effects of such asymmetric sympathetic ganglion innervations in man, studies were performed in 15 patients undergoing unilateral stellate ganglion blockade for the management of chronic arm pain. Methods and Results: Standard 12-lead ECGs, systemic blood pressure, body surface potential mapping, and radionuclide angiography were performed during rest and graded exercise before and after blockade. Successful unilateral blockade was accomplished in 13 of the patients, 11 of whom had right-sided blockade and two left-sided blockade. No significant changes due to blockade of stellate ganglia, including QT intervals, were detected during rest or graded exercise in standard ECGs. No cardiac rhythm disturbances occurred in these states, Body surface potential maps and arterial blood pressure were similar during resting supine and upright positions, as well as immediately after exercise before and after blockade. Unilateral ganglion blockade did not modify resting or exercise cardiac ejection fractions. Conclusion: Unilateral stellate blockade in man does not induce untoward cardiovascular effects during rest or exercise.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Futura Publishing, Inc.
    Pacing and clinical electrophysiology 25 (2002), S. 0 
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: STOVICEK, P., et al.: QT Dispersion in 120 Electrocardiographic Leads in Patients with Structural Heart Disease. The clinical significance of QT dispersion (QTd) measured in 12-lead ECGs is controversial. The aim of this study was to clarify factors that determine the QTd and its measurement errors in different lead arrays in patients with structural heart disease. Two blinded observers measured QT intervals on a computer screen from 120-channel ECG recordings in a retrospective set of 257 patients, comprising a group of 121 myocardial infarction (MI) survivors without ventricular tachyarrhythmia during a 6-month followup and a group of 136 survivors of ventricular tachyarrhythmia/fibrillation. QTd did not differ in patients with and without ventricular tachyarrhythmia/fibrillation. Eleven ventricular tachyarrhythmia/fibrillation survivors without structural heart disease had the lowest QTd (P ≤ 0.02). The strongest factor determining QTd and the magnitude of its measurement error was the lead array (P = 0.0001). Measurement errors had two components. The smallest relative errors were in the total body surface mapping array with one component related to interobserver reproducibility (9.1 ± 7.6%), and the other component related to accuracy of measurement of the QT interval (36 ± 16%). The authors estimated that a difference of QTd of at least 50 ms between study groups is required in a 12-lead ECG to draw any conclusions from the studies. In patients with structural heart disease, QTd from limited arrays of ECG leads was not a reliable measure. It correlated with the presence of structural heart disease, but not with arrhythmogenicity. An array consisting of ECG leads covering the entire chest allowed better reproducibility and measurement accuracy of QTd.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiovascular electrophysiology 6 (1995), S. 0 
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Localization of Ischemia. This study demonstrates the utility of an electrocardiographic Localization of Ischemia. This study demonstrates the utility of an electrocardiographic Inverse solution, coupled with body surface potential mapping (BSPM), in localizing acute ischemia in patients undergoing percutaneous transluminal coronary angioplasty (PTCA). PTCA balloon inflations produce complete occlusion and acute transient ischemia, which can be detected electrocardiographically with BSPM. Comparisons between maps recorded both during and before the inflation of the PTCA balloon allow patient- and artery-specific characterizations of the resulting ischemia. Knowledge of the patient's coronary anatomy and the location of the occlusion site by coronary angiography permit an estimation based on cardiac hemodynamics of the region of myocardium most likely to suffer from PTCA-induced ischemia. Electrocardiographic inverse solutions provide a means of predicting cardiac potentials from body surface maps. In this study, we describe an inverse solution we have developed to localize the transient ischemia produced by PTCA. To validate the procedure, we compared the locations of predicted ischemia in seven patients with a qualitative estimate of the perfusion region based on fluoroscopic examination of each patient's coronary anatomy and PTCA balloon location. In each case, the region of ischemia predicted by the model included the perfusion zone determined fluoroscopically. These results suggest that electrical changes induced by acute ischemia can be localized with an electrocardiographic inverse solution.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 99 (1992), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 328 (1979), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 10
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    Unknown
    Yellow Springs, Ohio : Periodicals Archive Online (PAO)
    The Antioch Review. 10:4 (1950:Dec.) 447 
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