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  • 1
    Electronic Resource
    Electronic Resource
    Species-specific patterns of hyperostosis in marine teleost fishes (1995)
    Springer
    Marine biology 121 (1995), S. 573-580 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The occurrence of swollen or hyperostotic bones in skeletal preparations, preserved museum material or whole fresh specimens of marine teleost fishes was identified in 92 species belonging to 22 families. Patterns of hyperostotic skeletal growth were typically consistent and often species-specific in all individuals larger than a certain size. The taxonomic distribution of hyperostosis in diverse phylogenetic groups suggests that it has arisen independently many times. Selected bones from two species of the family Carangidae, horse-eye jack Caranx latus Agassiz and crevalle jack Caranx hippos (Linnaeus), were examined in detail by light and electron microscopy. Nonhyperostotic bone contained osteoid-producing osteoblasts, resorbing osteoclasts, occasional osteocytes, and a rich vascular network, all characteristics of cellular bone. Thus, these fishes have a spatial juxtaposition of cellular and acellular bone tissues in adjacent and often serially homologous bone sites. The functional significance of hyperostosis is unknown, but it is a predictable manifestation of bone growth and development for the many taxa in which it occurs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00349291
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Inhibitors, enzymes and growth factors from shark cartilage
    Amsterdam : Elsevier
    Comparative Biochemistry and Physiology -- Part B: Biochemistry and 78 (1984), S. 609-616 
    Details
    ISSN: 0305-0491
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0305-0491(84)90106-8
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Self assembly of mixtures of collagen α-chains
    Amsterdam : Elsevier
    BBA - Protein Structure 668 (1981), S. 216-221 
    Details
    ISSN: 0005-2795
    Keywords: (Guinea pig) ; Chain distribution ; Collagen renaturation ; Cross-linking
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2795(81)90029-5
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Expression of differentiated function by mineralizing cultures of chicken osteoblasts
    Amsterdam : Elsevier
    Developmental Biology 122 (1987), S. 49-60 
    Details
    ISSN: 0012-1606
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0012-1606(87)90331-9
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Impaired recruitment and differentiation of osteoclast progenitors by osteocalcin-deplete bone implants
    Amsterdam : Elsevier
    Cell Differentiation 21 (1987), S. 247-254 
    Details
    ISSN: 0045-6039
    Keywords: Implant ; Osteocalcin ; Osteoclast ; Osteoclast progenitor ; Recruitment
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0045-6039(87)90479-9
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of Age on Serum Dehydroepiandrosterone Sulfate, IGF-I, and IL-6 Levels in Women (2000)
    Springer
    Calcified tissue international 66 (2000), S. 414-418 
    Details
    ISSN: 1432-0827
    Keywords: Key words: DHEAS — IGF-I — IL-6 — Age.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Data from animal and in vitro studies suggest that the growth-promoting effects of the adrenal androgen dehydroepiandrosterone sulfate (DHEAS) may be mediated by stimulation of insulin-like growth factor-I (IGF-I) and/or inhibition of interleukin 6 (IL-6), a cytokine mediator of bone resorption. This study tests the hypotheses that there are effects of age on serum DHEAS, IGF-I, and IL-6 levels, and that levels of IGF-I and IL-6 are related to DHEAS levels. The study included 102 women: 27 premenopausal and 75 postmenopausal, including 35 postmenopausal women with osteoporosis, as defined by bone mineral density scores by dual X-ray energy absorptiometry. DHEAS levels decreased significantly with age (r =−0.52, P 〈 0.0001) and IGF-I levels decreased significantly with age (r =−0.49, P 〈 0.0001). IL-6 levels increased significantly with age (r = 0.36, P= 0.008). IGF-I was positively correlated to DHEAS levels (r = 0.43, P 〈 0.0001, n = 102) and IL-6 levels were negatively correlated to DHEAS levels (r =−0.32, P= 0.021, n = 54). Levels of DHEAS and IGF-I were correlated with T scores of the spine and some hip sites. In a multiple variable model to predict DHEAS, age was an important predictor (P 〈 0.001), but osteoporosis status, IGF-I, and IL-6 were not. The median DHEAS level was lower in the postmenopausal osteoporotic women (67 μg/dl, n = 35) than in the nonosteoporotic postmenopausal women (106.3 μg/dl, n = 40, P= 0.03), but this was not significant after correction for age. Age accounted for 32% of the variance in DHEAS levels. In summary, DHEAS levels decreased with age and had a positive association with IGF-I levels and a negative association with IL-6 levels. DHEA deficiency may contribute to age-related bone loss through anabolic (IGF-I) and anti-osteolytic (IL-6) mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002230010084
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  • 7
    Electronic Resource
    Electronic Resource
    Atypical localisation of traumatic extradural hematomas (1989)
    Springer
    Neurosurgical review 12 (1989), S. 190-195 
    Details
    ISSN: 1437-2320
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01790646
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    A role for osteocalcin in osteoclast differentiation (1991)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 45 (1991), S. 292-302 
    Details
    ISSN: 0730-2312
    Keywords: apatite ; bone matrix ; foreign body giant cells ; implants ; extracellular matrix ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Specific cellular interactions with components of the extracellular matrix can influence cellular differentiation and development of many tissues. The extracellular matrix of bone is composed of organic constituents and a solid phase of calcium and inorganic phosphate (apatite). When implanted subcutaneously in rats, particles of bone matrix (BPs) recruit progenitors that differentiate into multinucleated cells with osteoclastic features. Because BPs deficient in osteocalcin, a bone matrix protein, were less efficient at promoting osteoclast formation than were normal BPs, we directly examined the influence of osteocalcin on osteoclast differentiation. We evaluated tissue responses to particles of synthetic crystalline apatite alone (Ap), having many of the features of native apatite of mature bone, or to apatite prepared with osteocalcin (Ap/OC), bovine serum albumin (Ap/BSA) or rat bone collagen (Ap/Col). Twelve days after subcutaneous implantation in normal rats, Ap, Ap/BSA, and Ap/Col particles generated a mild foreign body reaction with multinucleated cells in direct contact with the particles; these cells were negative for tartrate-resistant acid phosphatase (TRAP) activity and lacked ruffled borders. In contrast, Ap particles containing approximately 0.1% osteocalcin were partially resorbed and they generated more multinucleated cells that were TRAP-positive, were immunoreactive with an antibody against tartrate-resistant purple acid phosphatase, and displayed ultrastructural features of active osteoclasts including ruffled borders and clear zones. These data support the hypothesis that osteocalcin may function as a matrix signal in the recruitment and differentiation of bone-resorbing cells.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240450312
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