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  • 1
    Electronic Resource
    Electronic Resource
    The silence of the X (1992)
    [s.l.] : Nature Publishing Group
    Nature genetics 2 (1992), S. 169-170 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The existence of a nucleation point for the process of X-chromosome inactivation (XCI) has been inferred from studies of X-autosome translocations in humans, and from the elegant work of Cattanach on the mapping of a murine locus, Xce, influencing preferential inactivation of an X chromosome in a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1192-169
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  • 2
    Electronic Resource
    Electronic Resource
    Isolation and characterization of radiation-reduced hybrids containing portions of the proximal long arm of the human X chromosome: Identification of hybrids containing the Menkes' disease locus (1992)
    Springer
    Somatic cell and molecular genetics 18 (1992), S. 201-213 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The proximal long arm of the human X chromosome (Xcen→Xq13) encompasses an estimated 23 megabases of DNA and contains numerous identified genetic loci. In order to generate a highly enriched source of DNA from this region, radiation-reduced human-hamster hybrids were constructed and screened to identify those that contained at least part of proximal Xq. Eight such hybrids were identified and characterized by Southern blot and fluorescence in situ hybridization analyses to determine more precisely the human DNA complement in each. One hybrid contains the entire proximal long arm and will be useful for mapping Xcen→Xq13 in its entirety and for localizing genes within this region. Another hybrid contains a smaller portion of the proximal long arm that includes the region reported to contain the gene for Menkes' disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01233857
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  • 3
    Electronic Resource
    Electronic Resource
    Chromatin structure of active and inactive human X-linked phosphoglycerate kinase gene (1986)
    Springer
    Somatic cell and molecular genetics 12 (1986), S. 73-80 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have carried out a comparative analysis of DNase I sensitivity of the active and inactive X-linked phosphoglycerate kinase (Pgk)genes in human lymphoblast and fibroblast cultured cells. Three DNase I-sensitive regions were detected: a 5′ hypersensitive site, a sensitive region in the interior of the gene and a 3′ slightly sensitive site which we previously reported and have now mapped with some precision. A comparison of these sensitive sites in single and multiple X cell lines indicates that the sensitive sites are unique to the active X chromosome. A similar study of an X-linked Pgkpseudogene shows no difference in DNase I sensitivity between the pseudogenes on the active and inactive X chromosomes. These latter results imply that sex chromatin does not confer a unique level of DNase I resistance to DNA on the inactive X chromosome. The exact role of sex chromatin in differential DNase I sensitivity of genes on the inactive and active X chromosomes is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01560729
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  • 4
    Electronic Resource
    Electronic Resource
    Comparative methylation analysis of murine transgenes that undergo or escape X-chromosome inactivation (1998)
    Springer
    Chromosome research 6 (1998), S. 397-404 
    Details
    ISSN: 1573-6849
    Keywords: DNA methylation ; dosage compensation ; escape from X inactivation ; fluorescence in situ hybridization ; transgenic animals ; X-chromosome inactivation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We analyzed an X-linked metallothionein–vasopressin (MTVP) fusion transgene that undergoes X-chromosome inactivation (X inactiv ation) and an X-linked transferrin (TFN) transgene that escapes X inactivation with respect to methylation in the 5′ regulatory regions. The MTVP transgene promoter region is unmethylated when the transgene is on the active X chromosome and methylated when on the inactive X chromosome. Interestingly, the MTVP transgene is not detectably transcribed from the male X chromosome, although it is unmethylated, consistent with its availability for transcription. The TFN transgene promoter region is hypomethylated on both the active and inactive X chromosomes, consistent with its expression from both chromosomes. The TFN and MTVP transgenes have been mapped to chromosomal regions D and C, respectively, by fluorescence in situ hybridization. These observations are discussed in the context of our understanding of the role of DNA methylation in the spread and maintenance of X-chromosome inactivation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009229423535
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  • 5
    Electronic Resource
    Electronic Resource
    The chromatin domain as a unit of gene regulation (1988)
    New York, NY : Wiley-Blackwell
    BioEssays 9 (1988), S. 50-55 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The process by which the genetically identical cell lineages of a multicellular organism acquire the propensity to express distinct arrays of gene products is among the most significant and fascinating questions in modern biology. Not surprisingly, this complex process requires control at several levels, each level providing a condition that is necessary but not sufficient for transcription to occur. Evidence suggests that one level of control concerns a region of DNA much larger than the transcription unit itself - the chromatin domain. This domain must be in a specific chromatin conformation in order to permit transcription; other control mechanisms may be required to bring about overt transcription. A hypothesis concerning the nature of chromatin domains and the relationship between early replication and transcription potential is presented.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950090204
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  • 6
    Electronic Resource
    Electronic Resource
    Reactivation of inactive X-linked genes (1994)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 15 (1994), S. 504-514 
    Details
    ISSN: 0192-253X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020150609
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