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  • 1
    Electronic Resource
    Electronic Resource
    Follow-up of cyclosporin A treatment in Type 1 (insulin-dependent) diabetes mellitus: lack of long-term effects (1991)
    Springer
    Diabetologia 34 (1991), S. 429-434 
    Details
    ISSN: 1432-0428
    Keywords: Cyclosporin A ; Type 1 (insulin-dependent) diabetes mellitus ; immunotherapy ; C-peptide ; islet function ; remission of Type 1 diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the Canadian/European randomized controlled study on cyclosporin A (CsA) in recent onset Type 1 (insulin-dependent) diabetes, treatment with the immunosuppressive drug had increased and maintained Beta-cell function and clinical remission during the first 12 months. Following discontinuation of the study drug and double-blinding after a mean of 13.8 months former CsA patients doubled the daily insulin dose within 6 months reaching the level of former placebo patients. The difference in Beta-cell function between the two groups was also lost. Metabolic control (HbA1c) was transiently worse in the former CsA group. Adverse effects of cyclosporin A on systolic blood pressure, haemoglobin levels, serum potassium and creatinine levels also remitted during that time. We conclude that treatment with cyclosporin A for a mean of 13.8 months had no long-lasting effect on the course of Type 1 diabetes persisting beyond drug discontinuation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403182
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Assessment of analgesics in dental surgery outpatients (1980)
    Springer
    European journal of clinical pharmacology 18 (1980), S. 479-482 
    Details
    ISSN: 1432-1041
    Keywords: analgesia ; aspirin ; dental surgery ; analgesia assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The usefulness of the dental outpatient model for evaluating the efficacy of mild analgesics, first described by Cooper and Beaver, is demonstrated in five separate, double-blind, randomised, single-dose, parallel-group studies. Pain intensity and pain relief were recorded at hourly intervals for 3 h following the administration of aspirin 1000 mg and placebo. In all five studies aspirin was significantly more effective than placebo, with relatively small variability of the response between the studies. The method is simple, reliable and sensitive and complements the inpatient studies of postoperative pain hitherto more frequently used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00874659
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Efficacy of low-dose cyclosporin A in psoriasis: results of dose-finding studies (1990)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 122 (1990), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The efficacy of cyclosporin A (CyA) in severe psoriasis was analysed in 457 adult patients included in five European multicentre dose-finding studies. Initial CyA doses were 1–25 mg/kg/day in 33 patients, 2.5–3 mg/kg/day in 285 and 5 mg/kg/day in 139. After 3 months of treatment, the reduction of the Psoriasis Area and Severity Index (PASI) score was 35 ± 6% with 1–25 mg/kg/day of CyA, 57 ± 2% with 2.5 mg or 3 mg/kg/day and 86 ± 2% with 5 mg/kg/day (P 〈 0.001). The rates of success, defined by a PASI score reduction ± 75% or a score ± 8, were 24%, 52% and 88%, respectively. There were no differences in age, initial severity or duration of psoriasis. The improvement was maintained for 9 months or more in the majority of patients receiving continuous CyA therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1990.tb02880.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Renal function and blood pressure in psoriatic patients treated with cyclosporin A (1990)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 122 (1990), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Serum creatinine and blood pressure were measured in patients who had severe psoriasis and who were treated with cyclosporin A (CyA) in initial doses of 1.25mg (n = 34), 2.5 or 3 mg (n = 314), or 5 (n = 215) mg/kg/day. Of the 563 patients involved, 201 were treated for more than 3 months, and 100 received CyA continuously for 12 months or more. Sixty-eight additional patients were included as controls and received placebo (n = 42) or etretinate (n = 26). At doses of 2.5 and 5 mg/kg/day, CyA induced slight but significant dose-dependent increases in serum creatinine and blood pressure. Creatinine increases of 5o% or or more over baseline values were detected in 4% of the patients receiving 2.5 mg/kg/day and in 13% of those receiving 5 mg/kg/day. After an initial rise during the first weeks of treatment, mean creatinine level remained stable over 1 year provided that the CyA dose was reduced whenever creatinine levels increased by 30% or more over baseline. The incidence of hypertension was 10.6% and did not vary whether the CyA dose was 2–5 or 5 mg/kg/day. The first elevated blood pressures were recorded early after starting CyA therapy (median: i month). However, 3 months after stopping treatment, the increases in creatinine as well as in blood pressure were reversible and the levels did not significantly differ from baseline values.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1990.tb02883.x
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    Paper (German National Licenses)
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