ISSN:
1432-0428
Keywords:
Diabetes
;
Chinese hamsters
;
kidney
;
glucosyltransferase
;
subline
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A modified glucosyltransferase assay using degraded gelatin as acceptors was found to be enzyme concentration-and time-dependent in the Chinese hamster kidney extracts. In 54 Chinese hamsters selected from 7 highly inbred sublines with or without spontaneous glycosuria, the glucosyltransferase activity (0.78–3.25 unit/g) in the kidney was found to be significantly correlated (P=0.0002) to blood sugar concentrations (60–475 mg/dl). However, subline-dependent variation in glucosyltransferase activity was also evident and, in animals from 2 of the 5 diabetic sublines, similar activity of glucosyltransferase was found in their kidneys as in those of nondiabetic animals. It was concluded that renal glucosyltransferase activity was affected by blood sugar level as well as by genetically determined factor(s).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00258309
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