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  • 1
    Electronic Resource
    Electronic Resource
    Direct observation by Raman spectroscopy of the coexistence of a variety of ion-paired species in liquid ammonia solutions of alkali metal salts (1976)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 98 (1976), S. 4661-4662 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00431a061
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  • 2
    Electronic Resource
    Electronic Resource
    Lipoprotein composition in NIDDM: effects of dietary oleic acid on the composition, oxidisability and function of low and high density lipoproteins (1996)
    Springer
    Diabetologia 39 (1996), S. 667-676 
    Details
    ISSN: 1432-0428
    Keywords: Non-insulin-dependent diabetes mellitus ; low density lipoprotein oxidation ; low density lipoprotein fatty acids ; lipid peroxidation ; conjugated dienes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Oxidation of low density lipoprotein (LDL) plays an important role in the pathogenesis of atherosclerosis and is related to the fatty acid composition which is altered in diabetes mellitus. This study examines the relationship between the fatty acid composition of LDL and high density lipoprotein (HDL) and lipoprotein oxidation. A group of nine non-insulin-dependent diabetic (NIDDM) patients were compared to seven healthy control subjects before and after a high monounsaturated diet. Lipoproteins were isolated and oxidisability was measured by conjugated diene formation and lipid peroxide analysis. Serum HDL cholesterol was significantly lower in the diabetic patients. LDL cholesteryl ester linoleic acid in the diabetic patients was significantly higher at baseline and decreased after diet (p〈0.05) while oleic acid increased in both diabetic and non-diabetic subjects (p〈0.05). HDL cholesteryl ester oleic acid was lower in the diabetic patients compared with control subjects (p〈0.05) before diet and it increased significantly after diet (p〈0.05). LDL lipid peroxides and conjugated diene formation were related to LDL glycation (r=0.46, p〈0.05 and r=0.49, p〈0.05, respectively). Both decreased following diet (lipid peroxides for diabetic patients from 476±30 to 390±20 nmol/mg protein p〈0.05 and for control subjects from 350±36 to 198±30 nmol/mg protein p〈0.05). HDL conjugated diene formation decreased in both groups after diet but only significantly in the control group (55.4±7.5 to 53.2±6.7 nmol/mg protein for diabetic patients and 45.8±6.4 to 31.6±4.8 nmol/mg protein p〈0.05 for control subjects). There was a positive correlation between LDL lipid peroxide formation and percentage of cholesteryl ester linoleic acid in LDL from diabetic patients (r=0.61, p〈0.05) and control subjects (r=0.91, p〈0.01). Fatty acid composition of LDL was reflected in the composition of HDL. In the presence of HDL lipoprotein peroxidation decreased. This decrease in lipoprotein peroxidation was positively related to the percentage of linoleic acid in LDL (r=0.71, p〈0.05). This study confirms the close relationship between the fatty acid composition of LDL and HDL and demonstrates the importance of the fatty acid composition of the cholesteryl ester fraction in relation to LDL oxidation in diabetes. Linoleic acid in HDL appears to be a protecting factor against oxidation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418538
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  • 3
    Electronic Resource
    Electronic Resource
    Oxidation of low-density lipoprotein in NIDDM: its relationship to fatty acid composition (1995)
    Springer
    Diabetologia 38 (1995), S. 1300-1306 
    Details
    ISSN: 1432-0428
    Keywords: Key words Non-insulin-dependent diabetes mellitus ; low-density lipoprotein oxidation ; dietary fatty acids ; low-density lipoprotein composition ; glycated low-density lipoprotein.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The increased risk of atherosclerotic disease in diabetic subjects may be due to enhanced foam cell formation following an increased susceptibility of low density lipoprotein to oxidative modification. This study has compared fatty acid content and lipoprotein oxidisability in 10 non-insulin-dependent diabetic subjects with that in 10 control subjects. Both groups were normocholesterolaemic and the diabetic subjects had higher triglyceride levels (2.2 ± 0.4 vs 1.2 ± 0.2 mmol/l, p 〈 0.05). The fatty acid composition was compared in low density lipoprotein following Folch extraction, separation by thin layer chromatography (for the lipid classes) and analysis by gas liquid chromatography. Low density lipoprotein oxidisability was assessed by conjugated diene and thiobarbituric acid reacting substance formation in the presence of copper ions. The esterified/free cholesterol ratio was higher in the low density lipoprotein from patients compared to control subjects (2.9 ± 0.1 vs 1.9 ± 0.3, p 〈 0.05). Linoleic acid in the cholesteryl ester fraction of the lipoprotein was higher in the patients than in the control subjects (48.2 ± 2.2 % vs 42.4 ± 3.4 %, p 〈 0.05) as was the total quantity of linoleic acid in the cholesteryl ester fraction (317.8 ± 68.0 vs 213.2 ± 28.0 μg/mg protein, p 〈 0.05) and in the low-density lipoprotein as a whole (443.2 ± 70.0 vs 340.2 ± 28.2 μg/mg protein, p 〈 0.05). Lipoprotein oxidisability was also increased in the diabetic group with increased formation of thiobarbituric acid reacting substances (35.6 ± 7.2 vs 22.3 ± 3.5 nmol/mg protein, p 〈 0.05, increased total diene formation (502 ± 60 vs 400 ± 30 nmol/mg protein, p 〈 0.05) and increased rate of diene formation (7.2 ± 0.6 vs 5.1 ± 0.9 nmol diene · mg protein–1· min–1, p 〈 0.05). This study indicates that low-density lipoprotein from diabetic subjects is more susceptible to oxidation. This could, in vivo, accelerate foam-cell formation thereby increasing atherosclerotic risk in diabetic subjects. [Diabetologia (1995) 38: 1300–1306]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401762
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Lipoprotein composition in NIDDM: effects of dietary oleic acid on the composition, oxidisability and function of low and high density lipoproteins (1996)
    Springer
    Diabetologia 39 (1996), S. 667-676 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Non-insulin-dependent diabetes mellitus ; low density lipoprotein oxidation ; low density lipoprotein fatty acids ; lipid peroxidation ; conjugated dienes.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Oxidation of low density lipoprotein (LDL) plays an important role in the pathogenesis of atherosclerosis and is related to the fatty acid composition which is altered in diabetes mellitus. This study examines the relationship between the fatty acid composition of LDL and high density lipoprotein (HDL) and lipoprotein oxidation. A group of nine non-insulin-dependent diabetic (NIDDM) patients were compared to seven healthy control subjects before and after a high monounsaturated diet. Lipoproteins were isolated and oxidisability was measured by conjugated diene formation and lipid peroxide analysis. Serum HDL cholesterol was significantly lower in the diabetic patients. LDL cholesteryl ester linoleic acid in the diabetic patients was significantly higher at baseline and decreased after diet (p 〈 0.05) while oleic acid increased in both diabetic and non-diabetic subjects (p 〈 0.05). HDL cholesteryl ester oleic acid was lower in the diabetic patients compared with control subjects (p 〈 0.05) before diet and it increased significantly after diet (p 〈 0.05). LDL lipid peroxides and conjugated diene formation were related to LDL glycation (r = 0.46, p 〈 0.05 and r = 0.49, p 〈 0.05, respectively). Both decreased following diet (lipid peroxides for diabetic patients from 476 ± 30 to 390 ± 20 nmol/mg protein p 〈 0.05 and for control subjects from 350 ± 36 to 198 ± 30 nmol/mg protein p 〈 0.05). HDL conjugated diene formation decreased in both groups after diet but only significantly in the control group (55.4 ± 7.5 to 53.2 ± 6.7 nmol/mg protein for diabetic patients and 45.8 ± 6.4 to 31.6 ± 4.8 nmol/mg protein p 〈 0.05 for control subjects). There was a positive correlation between LDL lipid peroxide formation and percentage of cholesteryl ester linoleic acid in LDL from diabetic patients (r = 0.61, p 〈 0.05) and control subjects (r = 0.91, p 〈 0.01). Fatty acid composition of LDL was reflected in the composition of HDL. In the presence of HDL lipoprotein peroxidation decreased. This decrease in lipoprotein peroxidation was positively related to the percentage of linoleic acid in LDL (r = 0.71, p 〈 0.05). This study confirms the close relationship between the fatty acid composition of LDL and HDL and demonstrates the importance of the fatty acid composition of the cholesteryl ester fraction in relation to LDL oxidation in diabetes. Linoleic acid in HDL appears to be a protecting factor against oxidation. [Diabetologia (1996) 39: 667–676]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050494
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Oxidation of low-density lipoprotein in NIDDM: its relationship to fatty acid composition (1995)
    Springer
    Diabetologia 38 (1995), S. 1300-1306 
    Details
    ISSN: 1432-0428
    Keywords: Non-insulin-dependent diabetes mellitus ; low-density lipoprotein oxidation ; dietary fatty acids ; low-density lipoprotein composition ; glycated low-density lipoprotein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The increased risk of atherosclerotic disease in diabetic subjects may be due to enhanced foam cell formation following an increased susceptibility of low density lipoprotein to oxidative modification. This study has compared fatty acid content and lipoprotein oxidisability in 10 non-insulin-dependent diabetic subjects with that in 10 control subjects. Both groups were normocholesterolaemic and the diabetic subjects had higher triglyceride levels (2.2±0.4 vs 1.2±0.2 mmol/l, p〈0.05). The fatty acid composition was compared in low density lipoprotein following Folch extraction, separation by thin layer chromatography (for the lipid classes) and analysis by gas liquid chromatography. Low density lipoprotein oxidisability was assessed by conjugated diene and thiobarbituric acid reacting substance formation in the presence of copper ions. The esterified/free cholesterol ratio was higher in the low density lipoprotein from patients compared to control subjects (2.9±0.1 vs 1.9±0.3, p〈0.05). Linoleic acid in the cholesteryl ester fraction of the lipoprotein was higher in the patients than in the control subjects (48.2±2.2% vs 42.4±3.4%, p〈0.05) as was the total quantity of linoleic acid in the cholesteryl ester fraction (317.8±68.0 vs 213.2±28.0 Μg/mg protein, p〈0.05) and in the low-density lipoprotein as a whole (443.2±70.0 vs 340.2±28.2 Μg/mg protein, p〈0.05). Lipoprotein oxidisability was also increased in the diabetic group with increased formation of thiobarbituric acid reacting substances (35.6±7.2 vs 22.3±3.5 nmol/mg protein, p〈0.05, increased total diene formation (502±60 vs 400±30 nmol/mg protein, p〈0.05) and increased rate of diene formation (7.2±0.6 vs 5.1±0.9 nmol diene · mg protein−1 · min−1, p〈0.05). This study indicates that low-density lipoprotein from diabetic subjects is more susceptible to oxidation. This could, in vivo, accelerate foam-cell formation thereby increasing atherosclerotic risk in diabetic subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401762
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    The standard primipara as a basis for inter-unit comparisons of maternity care (1996)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 103 (1996), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To assess the suitability of the standard primipara (a subset of the obstetric population that has relatively low risk or intervention and of adverse outcome) for making inter-unit comparisons of indicators of the process and outcome of maternity care.Design Inter-unit comparison of 10 indicators of obstetric intervention and adverse outcome derived from routinely collected computerised data held on the St Mary's Maternity Information System.Setting Fifteen maternity units in the former North West Thames Region.Participants 15,463 primiparae who were delivered in 1992.Main outcome measures Proportion of primiparae within the standard definition; degree to which standard primiparae are associated with lower rates of intervention and adverse outcome, as compared to other primiparae.Results Within the database, 42.6% of all primiparae were found to be standard, with rates varying between units from 25.9% to 57.7%. As expected, the standard primiparous woman is at less risk of intervention or adverse outcome than other primiparae. All but one component variable of the standard definition is a significant risk factor for at least four of the 10 indicators. Statistically significant differences in indicator rates are seen between standard and nonstandard primiparae within units. Within the standard group, significant differences in rates of intervention and adverse outcome are seen between units. Units with relatively high levels of intervention within the higher risk nonstandard group also have relatively high levels of intervention within the standard group.Conclusions Use of the standard primipara, rather than the whole obstetric population, as the basis for inter-unit comparisons of maternity care will control for the substantial difference in case mix seen in different units, thereby increasing the validity of those comparisons. The technique has the additional benefit of clarifying the relationship between everyday clinical decision making and a unit's performance in comparative indicator reports. The approach must be combined with a separate study of the other groups in the case mix, such as multiparae and high risk primiparae. Additional nonoverlapping groups, homogeneous in terms of risk factors, should be defined and used to extend the basis on which comparisons may be made.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1996.tb09710.x
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  • 7
    Electronic Resource
    Electronic Resource
    Characterisation of cyclohexane hydroxylase; a three-component enzyme system from a cyclohexane-grown Xanthobacter sp. (1991)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 82 (1991), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1991.tb04904.x
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  • 8
    Electronic Resource
    Electronic Resource
    Apoptosis: a potential role for cytosolic transglutaminase and its importance in tumour progression
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Molecular Basis of Disease 1096 (1991), S. 312-318 
    Details
    ISSN: 0925-4439
    Keywords: Metastasis ; Programmed cell death ; Tumor progression ; ε(γ-Glutamyl)lysine
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0925-4439(91)90067-J
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  • 9
    Electronic Resource
    Electronic Resource
    High-pressure liquid chromatographic procedure for the determination of ε-(γ-glutamyl)lysine in proteins
    Amsterdam : Elsevier
    Analytical Biochemistry 124 (1982), S. 406-413 
    Details
    ISSN: 0003-2697
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-2697(82)90057-4
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  • 10
    Electronic Resource
    Electronic Resource
    A rapid and sensitive procedure for the quantitative determination of plasma amino acids
    Amsterdam : Elsevier
    Clinica Chimica Acta 125 (1982), S. 89-95 
    Details
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(82)90049-3
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