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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 22 (1987), S. 347-348 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1238
    Keywords: Key words Septicaemia ; Bleomycin-detectable iron ; Non-haem iron ; Iron overload
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To assess plasma iron status in critically ill patients with septic shock. Design: Observational, prospective study. Setting: Adult intensive care units in teaching and tertiary referral hospitals. Patients and participants: Fifteen adult patients with established septic shock. Normal control subjects (n = 10) were also investigated. Data from patients and controls were compared with previously published iron values in critical care patients. Measurements and results: The indices investigated and correlated with clinical scores of illness severity included bleomycin-detectable iron, non-haem iron; transferrin and its percentage iron saturation, and the iron binding (anti-oxidant) activity of transferrin. Bleomycin-detectable iron was not present in the plasma of patients with septic shock whilst the plasma transferrin remained unsaturated with iron. One patient in multi-organ failure displayed bleomycin-detectable iron in plasma (1.16 μmol/l) and had 100 % iron-saturation of transferrin. The plasma non-haem iron levels (7.84 ± 1.82 μmol/l) were the lowest of all critical care patient groups studied by us. The plasma transferrin levels were also low but resulted in a near normal percentage saturation of transferrin with iron (34.6 ± 6.5 %). The scores of clinical severity correlated with changes in plasma iron chemistry. Conclusions: Patients with septic shock rarely have iron saturated transferrin in their plasma leading to the presence of bleomycin-detectable iron.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 1 (1978), S. 311-312 
    ISSN: 0935-6304
    Keywords: Thin-Layer Chromatography, HPTLC ; Linoleic acid ; Lipid peroxidation ; Malondialdehyde ; Thiobarbituric acid test ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Peroxidised linoleic acid reacts with acidified thiobarbituric acid to give a chromogen absorbing maximally at 532 nm. This TBA reactant is chromatographically identical to the TBA-MDA adduct formed from linolenic acid and a pure MDA standard. Considerably less MDA is produced by peroxidised linoleic acid compared to that formed from linolenic acid. In this respect the type of acid used for the colour reaction appears to be important.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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