ISSN:
1432-1076
Keywords:
IL-2 deficiency
;
IL-2 therapy
;
IgM
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A patient with ataxia telangiectasia was treated with recombinant interleukin-2 (rIL-2) and the resulting immunological effects evaluated. The patient lacked IL-2 production, and immunoglobulin synthesis was also impaired. Treatment with IL-2 selectively increased serum IgM without any significant side effects. Therapy also restored B-cell function in vitro, IgM production as well as the proliferative response to Staphylococcus aureus strain Cowan I. These results suggest that IL-2 treatment may correct both T-cell and B-cell defects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00441517
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