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  • 1
    Electronic Resource
    Electronic Resource
    Role of Leukocytes during the Early Phase of Reperfusion Injury after Cold Preservation of Rat Liver (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 723 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb36782.x
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  • 2
    Electronic Resource
    Electronic Resource
    Comparison of University of Wisconsin and University of Pittsburgh solutions for heart transplantation (1996)
    Springer
    Transplant international 9 (1996), S. 380-385 
    Details
    ISSN: 1432-2277
    Keywords: Preservation, heart, rat ; Heart, preservation, rat ; UW solution, heart, rat ; Pittsburgh solution, heart, rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effectiveness of University of Wisconsin (UW) and University of Pittsburgh (UP) solutions for the preservation of rat hearts was compared. Lewis rat hearts were preserved with UW (group A, n=45) or UP (group B, n=45) solution for 0 or 24 h and then transplanted heterotopically into the recipients' abdomen. Ten recipients in each group were observed to obtain 1-week graft survival rates. Tissue water content and tissue content of adenine nucleotides were measured 2 h after transplantation in six grafts from each group. Six hearts preserved for 0 h and seven hearts preserved for 24 h were taken from each group 24 h after grafting for histopathology. The 1-week graft survival rates of groups A24 and B24 were 60% and 10%, respectively. In the 24-h preserved grafts, adenosine triphosphate (ATP) and energy charge [(ATP+adenosine diphosphate/2)/(ATP+adenosine diphosphate+adenosine monophosphate)] of groups A and B were 0.972±0.165 and 0.200±0.123 mg/g wet tissue (P〈0.05) and 74.4% and 61.1% (P〈0.05), respectively. The tissue water content of group A24 was 71.7%, whereas that of group B24 was 74.1% (P〈0.05). Histopathology revealed more severe muscle edema and necrosis and infiltration of polymorphonuclear cells in group B24 than in group A24. We conclude that UW solution is more appropriate for rat heart preservation than UP solution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335699
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  • 3
    Electronic Resource
    Electronic Resource
    Impact of adhesion molecules of the selectin family on liver microcirculation at reperfusion following cold ischemia (1996)
    Springer
    Transplant international 9 (1996), S. 454-460 
    Details
    ISSN: 1432-2277
    Keywords: Adhesion molecules, rat, liver transplantation ; Liver transplantation, adhesion molecules, rat ; Cytokines, liver transplantation, rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the role of adhesion molecules in the early phase of reperfusion following cold ischemia. Livers of male Lewis rats were preserved for 0 h (group A) or 24 h in University of Wisconsin (UW) solution without additives (group B) or in UW solution with anti-ICAM-1 antibody (group C) or anti-E-selectin-1, SLex and SLea antibodies (group D). The livers were then reperfused with diluted rat whole blood (DWB; groups A and B), DWB containing anti-ICAM-1 and LFA-1 antibodies (group C) or DWB containing anti-L-selectin, SLex and SLea antibodies (group D). The reperfusion was perfomed at 37°C for 1 h at 5 cm H2O of perfusion pressure. During reperfusion, hepatic microcirculation was assessed by monitoring portal and peripheral tissue blood flow. Bile production was significantly reduced in group B livers compared with those in group A. Anti-ICAM-1 and LFA-1 antibodies failed to improve hepatic microcirculation, whereas anti-LECAM-1, SLex and SLea antibodies significantly improved the microcirculation. Bile production in group C and D livers was comparable to that in group B livers. Preservation for 24 h significantly increased the release of TNF-α from 0.207 to 43.7 pg/g per hour during reperfusion. Monoclonal antibodies to the adhesion molecules did not suppress the release of TNF-α in groups C and D. Histological examination demonstrated a lack of leukocyte infiltration or thrombus in hetapic microvessels. The extent of hepatocyte necrosis did not differ among groups B, C, and D. We conclude that the microcirculatory disturbance in the early phase of reperfusion occurs as a result of the tethering of leukocytes through the interaction of the selectin family and their ligands, and that the ICAM-1-LFA-1 pathway is not involved in this step. The lack of improvement in bile production with antibodies to the selectin family and their ligands strongly suggests that other mechanisms participate in the deterioration of hepatic function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336822
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  • 4
    Electronic Resource
    Electronic Resource
    Can adenine nucleotides predict primary nonfunction of the human liver homograft? (1994)
    Springer
    Transplant international 7 (1994), S. 89-95 
    Details
    ISSN: 1432-2277
    Keywords: Adenine nucleotides, viability, liver ; Viability liver, adenine nucleotides ; Liver transplantation, nonfunction ; Nonfunction, liver transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sixty-eight primary liver grafts were analyzed to see whether adenine nucleotides (AN: ATP, ADP, and AMP) or purine catabolites (PC: adenosine, inosine, hypoxanthine, and xanthine) of tissue or effluent can predict primary graft nonfunction. AN, PC, and nicotinamide adenine dinucleotide, oxidized form (NAD+) of the tissue before (pretransplant) and after graft reperfusion (post-transplant) and of the effluent were analyzed. The graft outcome was classified into two groups (group A: successful, n=64; group B: primary nonfunctioning, n=4). No significant differences were observed in pretransplant measurements between groups A and B, whereas ATP, ADP, total AN, total AN+total PC (T) and NAD+, in post-transplant tissues, were significantly higher in group A. Xanthine in the effluent was significantly higher in group B than in group A. ATP, ADP, total AN, T, and NAD+ in post-transplant tissue were significantly associated with primary graft nonfunction by logistic regression analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336468
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  • 5
    Electronic Resource
    Electronic Resource
    Basic study on hepatic resection under partial perfusion cooling (1994)
    Springer
    World journal of surgery 18 (1994), S. 840-844 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Afin d'améliorer la fonction hépatique après reperfusion post-hépatectomie partielle accompagnée de refroidissement total ou partiel du foie (RF), une nouvelle solution de refroidissement contenant de la L-histadine (KM solution) a été développée. Après excision, des foies provenant de rats Lewis ont été perfusés par une solution de Ringer lactate (groupe A) ou la nouvelle solution KM (groupe B) pendant deux heures à 20°, puis ont été reperfusés avec du sang de rat à 37° sous une pression de 5 cm d'eau contrôlée par des débitmètres porte et tissulaires. A la fin de la reperfusion, la production de bile, la sécrétion de LDH ainsi que le contenu tissulaire en adénine triphosphate ont été mesurés. La récupération du débit porte et périphérique après reperfusion dans le groupe B, a été significativement améliorée par rapport au groupe A. La production de bile, la sécrétion de LDH ainsi que le contenu tissulaire en adénine triphosphate ont augmenté dans le groupe B. Après une perfusion in situ avec du Ringer lactate (groupe C) et KM (groupe D) pendant une heure à 20° suivie d'une hépatectomie partielle du lobe latéral du foie, la suivie à une semaine a été respectivement de 25% et de 100% (p〈0.05). La solution KM convient bien aux résections hépatiques associées au RF.
    Abstract: Resumen Con el objeto de mejorar la calidad de la función hepática luego de reperfusión después de hepatectomía parcial bajo hipotermia total o parcial del hígado, se desarrolló una nueva solución de perfusión que contiene 100 mM de L-histidina (Solución KM). Se extrajeron los hígados de ratas Lewis, los cuales fueron perfundidos por 2 horas a 20°C con Lactato de Ringer (Grupo A) o con solución KM (Grupo B), y reperfundidos con sangre de rata a 37°C y a una presión de perfusión de 5 cm H2O bajo monitoría del flujo portal y de los tejidos periféricos. Se efectuó la medición de la producción de bilis, la secreción de LDH y de trifosfato de adenosina tisular, luego de la reperfusión. La recuperación de los flujos portal y de los tejidos periféricos luego de la reperfusión fue significativamente mejor en los hígados del Grupo B que en los del Grupo A. La viabilidad de los hígados del Grupo B fue evaluda mediante la producción de bilis, el valor de ATP y de liberación de LDH, valores que aparecieron mejor preservados que en los hígados del Grupo A. Se practicó perfusión total in situ con lactato de Ringer (Grupo C) y con solución KM (Grupo D) por una hora a 20°C, seguida de hepatectomía parcial del lóbulo lateral izquierdo. La sobrevida a una semana de los Grupos C y D fue 25% y 100% respectivamente (p〈0.05). La conclusión es que la solución KM es adecuada para hipotermia parcial o total del hígado.
    Notes: Abstract To improve liver quality after reperfusion following partial hepatectomy under total or partial cooling of the liver (HPC), a new perfusion solution containing 100 mM l-histidine (KM solution) was developed. The livers of Lewis rats were removed and perfused for 2 hours at 20°C with lactated Ringer's (LR) solution (group A) or the KM solution (group B). They were reperfused with rat blood at 37°C at a perfusion pressure of 5 cmH2O while monitoring the portal and peripheral tissue blood flows. At the end of reperfusion, bile production, lactate dehydrogenase (LDH) secretion, and tissue adenosine triphosphate (ATP) was measured. Recovery of portal and peripheral tissue blood flows of the group B livers after reperfusion were significantly better than those of group A. Viability of the group B livers, assessed by bile production, tissue ATP value, and LDH release, was preserved better than that of group A livers. In situ total liver perfusion with LR (group C) and KM (group D) solutions for 1 hour at 20°C followed by partial hepatectomy of the left lateral lobe was performed. The 1-week survivals of the group C and D rats were 25% and 100%, respectively (p〈0.05). It was concluded that KM solution is suitable for HPC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00299081
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  • 6
    Electronic Resource
    Electronic Resource
    Assessment of hepatic viability during cold ischemic preservation (1995)
    Springer
    Transplant international 8 (1995), S. 434-439 
    Details
    ISSN: 1432-2277
    Keywords: Liver transplantation, viability testing ; Viability testing, liver transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A reliable and easy method for assessing the viability of a cold ischemia-preserved donor liver prior to transplanation into the recepient is needed. Based on an earlier study, we hypothesized that liver free fatty acid (FFA) leakage into the preservation fluid may be a useful, atraumatic indicator of irreversible ischemic injury. The aim of the present study was to determine the time course and magnitude of liver FFA release into the preservation solution and its correlation with the duration of cold ischemic preservation compatible with survival after transplantation. Rat livers (n=48) were flushed and preserved with University of Wisconsin (UW) solution at 4°C for 0, 12, 24, and 48 h. Thereafter, half of the livers were analyzed for preservation fluid FFA (gas-liquid chromatography) and protein. The other half were perfused with Krebs-Henseleit (KH) solution at 37°C for 1 h. Bile secretion and liver enzyme release (SGOT, SGPT, and LDH) were measured in addition to perfusate FFA and protein. Total FFA in the preservation fluid was 24 μg/g wet tissue after 12 h; it increased sharply 2.6-fold after 24 h and 3.7-fold after 48 h of preservation. Bile production was normal after 12 h of preservation but fell by 20% and 54% after 24 h and 48 h, respectively. LDH release rose from a value of 20 U/l at 0 time to 120 U/l and 260 U/l after 24 h and 48 h of preservation. These results suggest that liver viability declines sharply between 12 and 24 h of cold ischemic preservation, which corresponds with a sharp decrease in the 1-week survival from 100% to 33% after 12 h and 24 h, respectively, of cold ischemic preservation. We conclude that measuring FFA and LDH in the preservation solution of donor livers may be a useful means of assessing the quality of the cold-preserved liver before insertion into the recipient. We also speculate that a “threshold” FFA level in the UW preservation fluid indicating irreversible damage may be in the order of 35 μg total FFA/g liver. Studies on the clinical applicability of our findings are currently under way.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335594
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  • 7
    Electronic Resource
    Electronic Resource
    Increase in portal blood interleukin-6 soon after the commencement of digestive surgery (1996)
    Springer
    Surgery today 26 (1996), S. 890-894 
    Details
    ISSN: 1436-2813
    Keywords: interleukin-6 ; digestive surgical trauma ; portal blood ; liver function tests ; C-reactive protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To determine whether cytokines produced in the operative field during digestive surgery selectively spill over into the portal blood, the changes in interleukin-6 (IL-6) levels in portal and peripheral venous blood were assayed at several points in time from the commencement of surgery until 14 days later, in 11 patients. Similar changes in the IL-6 levels were observed in the portal and peripheral blood samples; however, the IL-6 levels in the portal blood reached a maximum 6–12 h after the commencement of surgery, being earlier than in the peripheral venous blood. In fact, between 3 and 12 h after the commencement of surgery, the IL-6 levels were higher in the portal blood by 33–81 pg/ml. By 24 h or more after the commencement of surgery, the IL-6 levels did not differ significantly in the two types of blood samples. Moreover, the C-reactive protein levels 2 days after surgery were even more closely correlated to the maximum IL-6 levels in the portal blood than to those in the peripheral venous blood. These results suggest that IL-6 produced during intraabdominal digestive surgery initially enters the portal blood, being trapped by IL-6 receptors in the liver, where it may regulate the synthesis of acute-phase proteins as a hepatocyte-stimulating factor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311790
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  • 8
    Electronic Resource
    Electronic Resource
    Extrapancreatic lymphoepithelial cyst of the pancreas (1996)
    Springer
    Journal of hepato-biliary-pancreatic surgery 3 (1996), S. 186-191 
    Details
    ISSN: 1436-0691
    Keywords: limphoepithelial cyst of the pancreas ; pancreas ; CA19-9
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A lymphoepithelial cyst is reported. A 68-year-old man consulted a surgeon, presenting with a sense of abdominal fullness. Ultrasonography and computed tomography revealed a large tumor, 10 cm in diameter, behind the head of the pancreas. Celiac arteriography at our hospital showed feeding arteries from the dorsal pancreatic artery and the pancreatic arcades. CA19-9 was elevated to 178 U/ml. Laparotomy was performed. The tumor was well demarcated from the surrounding tissue by a fibrous capsule and there was no continuity to the pancreatic parenchyma. Simple tumorectomy and distal gastrectomy for peptic gastric ulcer disease were performed. The cut surface revealed a multicystic lesion containing atheromatous substances. Histopathologically, the internal surface of the cyst was lined with stratified squamous epithelium containing mucin-producing cells; many germinal centers were observed in the cyst wall.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02350932
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  • 9
    Electronic Resource
    Electronic Resource
    Resection of the head of the pancreas in three patients with anomalous arrangement or occlusive diseases of the major abdominal visceral arteries (1996)
    Springer
    Journal of hepato-biliary-pancreatic surgery 3 (1996), S. 480-484 
    Details
    ISSN: 1436-0691
    Keywords: resection of head of the pancreas ; arterial occlusive disease ; anomalous arrangement of arteries
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We resected the head of the pancreas in three patients with occlusive diseases or anomalous arrangement of the abdominal visceral arteries. The first patient who was diagnosed with cancer of the head of the pancreas; pancreatoduodenectomy (PD) was performed. Preoperative celiac angiography showed no significant occlusion of the celiac axis, while superior mesenteric arteriography visualized the common hepatic artery, with delayed retrograde filling. At the completion of the PD, an unsuspected atherosclerotic celiac occlusion was identified. Celiac reconstruction was performed. The second patient was diagnosed with cystadenoma of the head of the pancreas and had congenital ostial occlusion of the superior mesenteric artery (SMA), with dilated pancreaticoduodenal (PD) arcades as a celiacomesenteric collateral pathway. Duodenum-preserving resection of the head of the pancreas was performed, with preservation of the PD arcades. The third patient was diagnosed with cancer of the common bile duct, and exhibited a replaced common hepatic artery that arose from the SMA and formed PD arcades. PD was performed, with revascularization of the common hepatic artery. Following surgery, the three patients have done well for 18, 27, and 9 months, respectively. Careful preoperative investigation to identify abnormalities of the visceral arteries is necessary before resection of the head of the pancreas is performed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02349796
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  • 10
    Electronic Resource
    Electronic Resource
    The effects of intraportal administration of prostaglandin E1 on liver ischemia and hepatectomy in rats (1998)
    Springer
    Journal of hepato-biliary-pancreatic surgery 5 (1998), S. 437-444 
    Details
    ISSN: 1436-0691
    Keywords: Key words: liver hemodynamics ; liver ischemia ; partial hepatectomy ; prostaglandin E1 ; reperfusion injury ; systemic arterial pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The effects of intraportal administration of prostaglandin E1 (PGE1) on portal venous flow, hepatic arterial flow, peripheral tissue blood flow, and systemic arterial flow before and after 60 min total liver ischemia followed by 70% partial hepatectomy in rats were investigated. Total liver ischemia was induced by occluding the hepatoduodenal ligament for 60 min. PGE1 at a dose of 0.5 μg/kg/min was infused intraportally for 15 min before inducing hepatic ischemia (preischemic period) and for 60 min after ischemia (postischemic reperfusion period) in the treatment group. Normal saline was infused in the control group. Seventy percent partial hepatectomy was performed during ischemia. Serum biochemical analysis and liver tissue histology were carried out 1, 3, and 24 h, and 1 and 24 h after reperfusion respectively. One-week survival of the PGE1 group was improved to 70% compared to that of the control group of 30%. Postischemia reperfusion values of portal and peripheral tissue blood flows in the PGE1 group were 6.33 ± 0.600 ml/min and 27.2 ± 23.5 (arbitrary), and were significantly different from those of the control group of 4.34 ± 0.400 ml/min and 23.5 ± 5.54 (arbitrary), respectively. There was no significant difference in hepatic arterial flow between the two groups. Serum alkaline phosphatase decreased significantly in the prostaglandin group. Histological examination revealed a significant portal venous congestion in the control group 1 and 24 h after reperfusion. The extent of the sinusoidal congestion was also severe in the control group 24 h after reperfusion. It was concluded that PGE1 has a protective effect against liver damage when the liver was injured by warm ischemia and reperfusion followed by partial resection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005340050069
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