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  • 1
    Electronic Resource
    Electronic Resource
    Hyperoxia: Effects on the vascularization of the developing central nervous system (1980)
    Springer
    Acta neuropathologica 51 (1980), S. 141-144 
    Details
    ISSN: 1432-0533
    Keywords: Blood vessel ; Brain ; Development ; Hyperoxia ; Hamster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Litters of experimental and control hamsters were killed on postnatal days 3, 4, 7, 14, 21, and 28 following 7 days of exposure to 85% oxygen at normabaric pressure. Using analysis of variance (ANOVA), light microscopy quantitation of the number of blood vessel profiles per unit area in the region of the frontal cerebral cortex demonstrated that the combined effect of treatment and age on the animals produced a highly statistically significant difference (P〈0.001) in the numbers of blood vessel profiles. The statistically separated treatment effect was also found to be significant (P〈0.05). The data are summarized in Table 1. Ultrastructural analysis of animals exposed to oxygen only, i.e., killed without being returned to the normal air environment, demonstrated severe signs of vaso-obliteration. Animals which were returned to a normal atmosphere following 7 days in oxygen showed a progressive decrease in the signs of vaso-obliteration. This present study demonstrated the marked similarity between the effects of hyperoxia on the CNS and on the neuro-retina.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690456
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  • 2
    Electronic Resource
    Electronic Resource
    The postnatal development of blood vessels in the substantia gelatinosa of rat cervical cord  -  an ultrastructural studySupported in part by grants from Medical Research Council of Canada, National Cancer Institute of Canada and University of Manitoba-Grant-in-Aid. (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 178 (1974), S. 691-709 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Light microscopy of semithin sections revealed an increase in blood vessel profiles between one and three weeks postnatal. Ultrastructurally, at birth, there were few patent vessels, but endothelial cells enclosing a slit-like lumen were numerous. The endothelial cells contained a high concentration of free ribosomes and pinocytotic vesicles. Pseudopod projections of the endothelial cells into the vascular lumen were often present. The nuclei were very irregular and dense with clumped chromatin. The basal lamina varied in thickness. During the period between one and three weeks the nuclei of endothelial cells became less dense; the lumen became patent and the endothelial wall progressively thinner. The periphery of the vessel became completely surrounded by glial end feet and the basal lamina was regular and prominent. By three weeks, most blood vessels resembled blood vessels observed in a mature animal. Pericytes were present at all stages of development. The extracellular space which was quite conspicuous at birth was greatly reduced by the third week.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091780404
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  • 3
    Electronic Resource
    Electronic Resource
    Ultrastructural studies on postnatal differentiation of neurons in the substantia gelatinosa of rat cervical spinal cordThis work has been presented at the Annual meeting of the American Association of Anatomists, Dallas 1972.Supported in part by the Medical Research Council of Canada, National Cancer Institute of Canada and University of Manitoba - Grant-in-Aid. (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 183 (1975), S. 323-337 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Neuroblasts of the substantia gelatinosa at birth were small with large oval nuclei and scanty cytoplasm. The cytoplasm possessed ribosomes and mitochondria. Granular endoplasmic reticulum and Golgi complexes were generally absent or rudimentary. Electron dense bodies were seldom observed. By the end of the first week, the nuclei of several cells demonstrated early nuclear invaginations; cytoplasm exhibited growth cones, a well developed granular endoplasmic reticulum and Golgi complexes. At several points the channels of endoplasmic reticulum became continuous with the perinuclear space. By the end of the second week, differentiation of the neuroblasts was more advanced. More nuclei showed invagination of their contour. The cytoplasm revealed well developed granular endoplasmic reticulum and multiple Golgi complexes. Numerous vesicles and dense bodies were found adjacent to the Golgi complexes. Arrays of agranular endoplasmic reticulum also appeared late in the second week. By the third week, features of neuronal differentiation, such as nuclear invaginations, granular endoplasmic reticulum, agranular membrane configurations, multiple Golgi complexes and dense bodies in the cytoplasm became well established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091830208
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    Paper (German National Licenses)
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