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  • 1
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Δ 1-Tetrahydrocannabinol (Δ 1-THC) has been quantified directly in erythrocyte membranes from drug-treated mice using gas chromatography/mass spectrometry. Concentrations of approximately 6 ngΔ 1-THC/mg membrane protein (10−5 M) were found when effects of the drug on behavior were prevalent. At these concentrations the drug produced a decrease in membrane order as measured by ESR.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 76 (1972), S. 3217-3220 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 38 (1973), S. 4274-4278 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 6 (1999), S. 2380-2392 
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Tokamaks exhibit several types of relaxation oscillations such as sawteeth, fishbones and Edge Localized Modes (ELMs) under appropriate conditions. Several authors have introduced model nonlinear dynamic systems with a small number of degrees of freedom which can illustrate the generic characteristics of such oscillations. In these models, one focuses on physically "relevant" degrees of freedom, without attempting to simulate all the myriad details of the fundamentally nonlinear tokamak phenomena. Such degrees of freedom often involve the plasma macroscopic quantities such as pressure or density and also some measure of the plasma turbulence, which is thought to control transport. In addition, "coherent" modes may be involved in the dynamics of relaxation, as well as radial electric fields, sheared flows, etc. In the present work, an extension of an earlier sawtooth model (which involved only two degrees of freedom) due to the authors is presented. The dynamical consequences of a pressure-driven "coherent" mode, which interacts with the turbulence in a specific manner, are investigated. Varying only the two parameters related to the coherent mode, the bifurcation properties of the system have been studied. These turn out to be remarkably rich and varied and qualitatively similar to the behavior found experimentally in actual tokamaks. The dynamic model presented involves only continuous nonlinearities and is the simplest known to the authors that can yield features such as sawteeth, "compound sawteeth" with partial crashes, "monster" sawteeth, metastability, intermittency, chaos, periodic and "grassy" ELMing in appropriate regions of parameter space. The results suggest that linear stability analysis of systems, while useful in elucidating instability drives, can be misleading in understanding the dynamics of nonlinear systems over time scales much longer than linear growth times and states far from stable equilibria. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 62 (1993), S. 65-100 
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 37 (1972), S. 3365-3365 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 4 (1990), S. 135-136 
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Ready identification of hydroxy metabolites of cannabichromene (CBC) by mass spectrometry of their trimethylsilyl derivatives is prevented by the dominant fragmentation to give a substituted chromenyl ion; this suppresses ions diagnostic of the position of metabolic hydroxylation. To overcome this difficulty, metabolites were hydrogenated over a rhodium/alumina catalyst to reduce the double bond responsible for chromenyl ion formation and to redirect the fragmentation to the site of metabolic attack. This resulted in the production of abundant diagnostic fragment ions enabling all monohydroxy-CBCs to be readily identified.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Identification of isomeric monohydroxy metabolites of 6a,10a-trans-tetrahydrocannabinols (THCs) by gas chromatography/mass spectrometry as their trimethylsilyl derivatives is aided by catalytic hydrogenation to hydroxyhexahydrocannabinols (hydroxy-HHCs) in cases where the metabolites themselves give similar spectra. This method gives common products from a range of hydroxy metabolites of isomeric-THCs which can be compared with reference compounds synthesized from available hydroxy-THCs from the Δ8 and Δ9-series. Sufficient of these compounds are available to enable hydroxy-HHCs to be prepared with hydroxy groups in most positions accessible to metabolic enzymes. This technique provides a simple alternative to a laborious synthesis of each new metabolite for confirmatory purposes and enables all metabolites in a metabolic experiment to be identified in a single sample. Catalytic hydrogenation was achieved using rhodium on alumina in methanol; this gave rapid, quantitative hydrogenation of underivatized metabolites without the elimination of the hydroxy groups inherent with hydrogenation with other common catalysts. The method was validated by an examination of the metabolites of Δ11 THC in rats and comparison of the results with published work.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 7 (1993), S. 614-619 
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Comparative studies of the matrix-assisted laser desorption ionization of complex oligosaccharides were made using a range of mono, di- and tri-substituted benzoic acids, substituted coumarins and cinnamic acids. The best results were obtained with 2,5-dihydroxybenzoic acid (2,5-DHB). Detection limits using this matrix were in the range of 100 fmol for complex and high mannose sugars, some 2-fold better than those obtained with α-cyano-4- hydroxycinnamic acid and 10-fold better than with an earlier oligosaccharide matrix, 3-amino-4-hydroxybenzoic acid. The strongest signals were achieved with a matrix-to-sample ratio of about 5000:1. Little correlation was found between the measured peak height and sample loading when 3-amino-4-hydroxybenzoic acid was used as the matrix and the signal appeared to saturate at a sample level of around 30 pmol. However, good correlation was found between the amount of sample loaded onto the target and the response when an analogous compound was used as an internal standard and peak ratios were measured. In contrast to this, the use of 2,5-dihydroxy-benzoic acid as the matrix enabled the oligosaccharide to be measured over the range 100fmol to at least 100pmol with an excellent linear correlation between sample quantity and response and without the need of a standard. No evidence of saturation was found with this matrix. With 2,5-DHB (other matrices were not tested), the oligosaccharide signal strength was found to fall with increasing molecular weight in a linear manner and similar to that found previously with proteins. Signal strength from individual sugars also fell when these were measured in mixtures. Derivatization (peracetylation) generally caused an increase in signal strength.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 9 (1982), S. 411-418 
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectra of the trimethylsilyl derivatives of 22 3β-hydroxy-Δ5-pregnenes have been examined with the aid of deuterlum labelling and high resolution mass measurements. The influence of additional hydroxy and keto substituents on the characteristic fragment ions is discussed and fragmentation mechanisms for several ions characteristic of hydroxylation at specific sites (11 and 16) are proposed.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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