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  • 1
    Electronic Resource
    Electronic Resource
    Reduction of gastric acid secretion (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 39 (1984), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cimetidine 10 mg/kg orally was given at varying times from 60 to 240 minutes pre-operatively to 100 healthy children between the ages of 6 months and 14 years. Cimetidine proved to be most effective when given between 120 and 180 minutes before the induction of anaesthesia. All patients in this group had a gastric pH of more than 2.5 and the mean volume aspirated was also significantly lower than that in the control group. The average peak blood concentration after 10 mg/kg oral cimetidine in four healthy children was 3.25 μg/ml (range 1.20-4.80) and occurred 75 minutes after administration (range 60-120 minutes). In these patients the mean (SD) hay-life of cimetidine was 138 (18) minutes. The reduction of gastric juice volume and acidity produced by 10 mg/kg oral cimetidine given 120—180 minutes prior to induction of anaesthesia has important clinical implications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1984.tb07269.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Acid–base, electrolyte and metabolite concentrations in packed red blood cells for major transfusion in infants (2001)
    Oxford UK : Blackwell Science Ltd
    Pediatric anesthesia 11 (2001), S. 0 
    Details
    ISSN: 1460-9592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Methods: Acid–base, electrolyte and metabolite concentrations were determined in 100 U of packed red blood cells (RBC) preserved in extended-storage media to be used for major transfusion in paediatric and cardiac surgery. Results: In fresh RBC, low pH, bicarbonate (cHCO3−), base excess (BE) and high glucose values were observed all outside the physiological range. With lengthening storage duration, values of pH, cHCO3−, BE, sodium and glucose decreased and carbon dioxide, potassium and lactic acid concentrations increased [mean ± SD (range): storage duration 6.7 ± 3.8 (1–17) days, pH 6.79 ± 0.1 (6.53–6.99); mmol·l–1: cHCO3− 11.1 ± 1.5 (6.2–14.5), BE − 29.2 ± 4.1 ([−39.4] − [−20.9]), potassium 20.5 ± 7.8 (4.2–43.6), glucose 24.1 ± 6.1 (16.7–29.2), lactic acid 9.4 ± 4 (4.3–21.4)]. Conclusions: Massive and rapid transfusion of RBC may lead to a severe burden of hydrogen ions, carbon dioxide, potassium, glucose and lactic acid and this can be avoided by cell saver blood processing, when autologous erythrocytes from the operative field are saved and substrate load and storage lesions from packed red blood cells are minimized in one step by washing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9592.2001.00637.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    How to deal with air pollution in paediatric operating theatres (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Pediatric anesthesia 2 (1992), S. 0 
    Details
    ISSN: 1460-9592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9592.1992.tb00215.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Haemodynamic, acid–base and electrolyte changes during plasma replacement with hydroxyethyl starch or crystalloid solution in young pigs (2000)
    Oxford, UK : Blackwell Science Ltd
    Pediatric anesthesia 10 (2000), S. 0 
    Details
    ISSN: 1460-9592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We investigated haemodynamic, acid–base and electrolyte changes during almost total plasma replacement with hydroxyethyl starch (HES) and physiological balanced electrolyte solution (PBE) by using a cell saver in ten young pigs. In the PBE group an additional 3550 (444) ml crystalloid solution [Mean (SD)] was infused over the course of the study in order to maintain pulmonary capillary wedge pressure. Plasma protein levels decreased in both groups and the colloid osmotic pressure increased in HES and decreased in PBE. At the end of the study, body weight [HES 10.4 (1), PBE 13.1 (1.4) kg, P 〈 0.01] and lactic acid concentration [HES 0.9 (0.3), PBE 2.9 (1.3) mmol.l −1, P 〈 0.01] was higher and tissue oxygen delivery [HES 327 (22), PBE 89 (29) ml.min·m2, P 〈 0.01] was lower in the PBE group. There were only moderate acid–base changes in both groups, but at the end, anion gap was significant lower in HES. In conclusion, maintenance of colloid osmotic pressure close to the physiological range of infants seems to be advantageous during major paediatric surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9592.2000.00458.x
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  • 5
    Electronic Resource
    Electronic Resource
    150. Stoffwechselveränderungen beim Politrauma. tisierten, ein Beitrag zum Problem der Operabilität (1973)
    Springer
    Langenbeck's archives of surgery 334 (1973), S. 929-929 
    Details
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde versucht, den Zustand Schwerverletzter, gerade im Hinblick auf das Operationsrisiko, durch biochemische Untersuchungen genauer zu erfassen. Nach intensivpflegerischen Stabilisierungsmaßnahmen mußten 36 Patienten erneut operativ versorgt werden. Vor und 24 Std bzw. 48 Std nach dem Eingriff wurde Lactat, Pyruvat, 2,3-DPG, alpha-HBDH und MDH aus zentralvenösem Blut bestimmt. Patienten mit gutem bzw. ungünstigem postoperativen Verlauf zeigten dabei eine statistisch signifikante Differenz der Werte. Die unterschiedliche Ausgangslage der Patienten, durch anderweitig zugängliche Daten nicht unbedingt erfaßbar, wurde durch die Synopsis der untersuchten Stoffwechselparameter deutlich.
    Notes: Summary The purpose of the study was to determine the condition of severely injured patients more accurately by way of biochemical evaluations, with especial reference to surgical risk. Following intensive care, 36 patients again had to undergo operation. Before the surgical intervention and 24 h and 48 h after, lactate, pyruvate, 2,3-DPG, isoenzyme 1 of LDH and MDH were determined in central venous blood. There were statistically significant differences in the pertinent values between patients with good and those with poor postoperative courses. The diverse starting point of patients, not necessarily manifested by other available data, was obvious from the synopsis of the metabolic parameters studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01286685
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    Paper (German National Licenses)
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