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  • 1
    Electronic Resource
    Electronic Resource
    Value of event-related P300 subcomponents in the clinical diagnosis of mild cognitive impairment and Alzheimer's Disease (2002)
    Oxford, UK : Blackwell Publishing
    Psychophysiology 39 (2002), S. 0 
    Details
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Accurate and early diagnosis of Alzheimer's Disease (AD) with reliable and noninvasive methods is of great importance for clinical practice as effective and specific antidementive therapies become available. The aim of the study was to evaluate the clinical relevance of event-related P300 in the early diagnosis of AD. Thirty patients with AD, 26 patients with mild cognitive impairment (MCI) from our Memory Clinic and 26 age-matched healthy controls (HC) were studied with event-related P300 potentials. Amplitudes of temporo-basal dipoles (TB-P300) were significantly diminished in AD compared to HC and MCI. Furthermore, latencies of temporo-superior dipoles (TS-P300) were significantly prolonged in AD compared with HC. Sensitivity was 90.0% for the differentiation of patients with AD from HC (specificity 79.1%) using reduced TB-P300 amplitudes and prolonged TS-P300 latencies. Similar results were found using Pz amplitudes as well as Fz latencies. Our data suggest that TB-P300 amplitudes and TS-P300 latencies may be an accurate clinically available, nonexpensive, noninvasive, and reliable marker for AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1469-8986.3920175
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  • 2
    Electronic Resource
    Electronic Resource
    Ventricle size and P300 in schizophrenia (1994)
    Springer
    European archives of psychiatry and clinical neuroscience 243 (1994), S. 352-354 
    Details
    ISSN: 1433-8491
    Keywords: Ventricle brain ratio ; Cranial computed tomography ; Auditory event-related potentials ; P300 ; Schizophrenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Both ventricular enlargement and reduced P3 amplitudes are consistent findings in schizophrenic patients, suggesting that the two measures reflect a common underlying pathophysiological process in schizophrenia. Investigating 14 stabilized schizophrenic outpatients, a relationship between the size of the lateral ventricles as well as of the third ventricle on CT scans and the auditory event-related P3 amplitude was, however, not found. This negative result suggests that ventricular enlargement and reduced P3 amplitudes in schizophrenics reflect different pathophysiological processes. It is assumed that the P3 amplitude is related rather to abnormalities in the temporal lobe of schizophrenic patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02195730
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Markers from event-related potential subcomponents and reaction time for information processing dysfunction in schizophrenia (1998)
    Springer
    European archives of psychiatry and clinical neuroscience 248 (1998), S. 307-313 
    Details
    ISSN: 1433-8491
    Keywords: Key words Schizophrenia ; Cognitive ; Auditory evoked potentials ; Reaction time
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Event-related potentials (ERPs) can serve as markers for cognitive processing stages. Identification of those ERPs altered in schizophrenia offer information about cognitive dysfunction. Auditory evoked potentials (AEPs) were elicited within an oddball paradigm in 35 schizophrenic patients and compared with 35 healthy controls. N100 and P200, as well as N200, frontal P300 and parietal P300 subcomponents, were separated using dipole source analysis. The amplitudes of the N100 and the parietal P300 measured in schizophrenics were diminished. The input-related processing stages (N100 and P200) were not altered, whereas later, the deviant and task-related processes (N200, frontal P300, parietal P300 and reaction time) were significantly prolonged in schizophrenia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004060050055
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Dipole Localization and Test-Retest Reliability of Frequency and Duration Mismatch Negativity Generator Processes (1997)
    Springer
    Brain topography 10 (1997), S. 3-8 
    Details
    ISSN: 1573-6792
    Keywords: Event-related potentials ; Test-retest-reliability ; Source localization ; Neural representation ; Auditory cortex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The mismatch negativity (MMN) is an event related potential component elicited by changes in duration, frequency or intensity of the stimuli during repetitive series of equal standard stimuli. In the present study we compared duration and frequency MMN using dipole source analysis concerning both the test-retest reliability of MMN-amplitudes and the locations of the potential sources. Furthermore, the influence of attention for test-retest-reliability was studied. Therefore, two groups of healthy subjects were investigated with different attentional manipulations. Twenty-one healthy subjects had to perform a visual attention task during the recording and 21 healthy subjects had no additional task to perform. All subjects were studied twice with a time interval of 3 weeks. Test-retest reliability was sufficiently high for the frequency but slightly lower for the duration MMN. The locations of the frequency and duration MMN-dipoles were in the auditory cortex with a more anterior and caudal location for the frequency MMN-dipoles. The latter finding supports the hypothesis that the frequency and duration MMNs have separate neuronal generators.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022214905452
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    Paper (German National Licenses)
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