ISSN:
1569-8041
Keywords:
breast cancer
;
high-dose chemotherapy
;
minimal residual disease
;
stem cell transplantation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The increasing use of high-dose chemotherapy with autologous hematopoietic transplantation for the treatment of solid malignancies has raised concern about the role of tumor cells contaminating the grafts. Minimal residual disease (MRD) in autologous grafts has became a dynamic and intensively studied field in oncology. This review discusses the current status of MRD in breast cancer autografts and presents existing data on detection methodology, clinical relevance, biologic characteristics and purging techniques.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008344708061
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