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  • 1
    Electronic Resource
    Electronic Resource
    Ex vivo analysis of desmoglein 1-responsive T-helper (Th) 1 and Th2 cells in patients with pemphigus foliaceus and healthy individuals (2005)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Experimental dermatology 14 (2005), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract:  Pemphigus foliaceus (PF) is a severe autoimmune bullous disorder, characterized by autoantibodies (autoAb) against desmoglein 1 (Dsg1). As T cells may be critical in the pathology of PF, the aim of the present study was to identify and characterize autoaggressive T-helper cells reactive to Dsg1 in PF patients and healthy individuals. Eight patients with the clinical diagnosis of PF and six HLA class II-matched healthy individuals were examined. By magnetic cell-sorting (MACS) cytokine-secretion assay, Dsg1-responsive T-helper (Th) 1 and Th2 cells were isolated and cloned by limiting dilution. The generated T-cell clones (TCC) were characterized regarding proliferative response, TCR Vβ-chain usage, and cytokine profile upon in vitro stimulation with Dsg1. Both Dsg1-reactive Th1 and Th2 cells were detected in PF patients and controls at similar frequencies. A total of 15 Th1 and Th2 clones were isolated from patients and 27 TCC from healthy controls. Analysis of TCR Vβ-chain usage of autoreactive T cells from both groups revealed no predominance of a specific Vβ chain. Noteworthy, the isolated TCC showed a polarized Th1- or Th2-like phenotype upon in vitro culture and stable expression of Th1 or Th2 cytokines during long-term in vitro culture. In summary, our data demonstrate that T-cell autoreactivity against Dsg1 is not restricted to patients with PF. Moreover, both Th1 and Th2 cells were present in patients and healthy donors, suggesting that the loss of B-cell tolerance against Dsg1 in PF is not exclusively determined by the presence of autoaggressive T cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0906-6705.2005.00329.x
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  • 2
    Electronic Resource
    Electronic Resource
    Contact dermatitis from levobunolol eyedrops (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 41 (1999), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1999.tb06211.x
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  • 3
    Electronic Resource
    Electronic Resource
    Detection of hydrogen atoms in SiH4–H2 radio-frequency plasmas using two-photon laser-induced fluorescence (2002)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 92 (2002), S. 710-715 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Two-photon laser-induced fluorescence spectroscopy is used to detect ground-state atomic hydrogen in highly diluted SiH4–H2 radio-frequency discharges currently used for microcrystalline silicon thin film deposition. Along with the fluorescence coming from the hydrogen atoms created in the discharge, additional atoms arising from photodissociation of silicon containing species at 205 nm are observed. This parasitic effect is identified as resulting mainly from the disilane molecules formed in the plasma. Hydrogen atoms created in the plasma and originating from the photodissociation are discriminated by a spectral analysis of the laser-induced fluorescence line profile and relative densities are deduced. Some results on the hydrogen atom and disilane concentrations as functions of the silane dilution, radio-frequency power, gas pressure, and gas temperature are given to illustrate the potentiality of such a diagnostic in SiH4–H2 discharges containing up to 6% of silane. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1486033
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  • 4
    Electronic Resource
    Electronic Resource
    Immunologic mechanisms in hypersensitivity reactions to metal ions: an overview (2000)
    Copenhagen : Munksgaard International Publishers
    Allergy 55 (2000), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Metal ions such as Ni2+, Co2+, Cu2+, or Cr3+ are haptens with a high immunogenic potential, as contact dermatitis caused by ionic metals occurs in about 10–15% of the human population. Since alloys containing Ni2+, Co2+, and Cr3+ are components of implants in replacement surgery, dentures, orthodontic wires, and various other devices, adverse reactions to metal ions create serious problems in practical medicine as incompatibility reactions to metal-containing biomaterials. On the other hand, contact dermatitis to metal ions such as Ni2+ is a well-established model for studying the molecular mechanisms involved in the recognition of haptens by the immune system. Although many investigations have been performed to elucidate the molecular interactions causing contact hypersensitivity in man, many aspects remain to be clarified. This review will focus on the experimental data accumulated so far on the immunologic mechanisms responsible for the recognition of metal ions by T cells and eliciting adverse immune reactions causing contact dermatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2000.00107.x
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  • 5
    Electronic Resource
    Electronic Resource
    Deficiency of PORCN, a regulator of Wnt signaling, is associated with focal dermal hypoplasia (2007)
    [s.l.] : Nature Publishing Group
    Nature genetics 39 (2007), S. 833-835 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Focal dermal hypoplasia (FDH) is an X-linked dominant multisystem birth defect affecting tissues of ectodermal and mesodermal origin. Using a stepwise approach of (i) genetic mapping of FDH, (ii) high-resolution comparative genome hybridization to seek deletions in candidate chromosome areas and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng2052
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  • 6
    Electronic Resource
    Electronic Resource
    Über eine typhöse Erkrankung, verursacht durch Salmonella cholerae suis (1957)
    Springer
    European journal of pediatrics 80 (1957), S. 443-450 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Unter Hinweis auf die epidemiologische Problematik des Paratyphus C wird über eine im Bereich Nordbaden beobachtete Infektion eines 4 jährigen Kindes durch Salmonella cholerae suis berichtet, die unter dem Bild eines Typhus abdominalis verlief. Die Erkrankung war kompliziert durch Blutungen im Bereich des Intestinaltraktes und durch Gangrän eines Unterschenkels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00438752
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  • 7
    Electronic Resource
    Electronic Resource
    Gemeinsames Auftreten einer extraabdominellen Fibromatose und posttraumatischer Keloide (1994)
    Springer
    Der Hautarzt 45 (1994), S. 113-116 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter: Extraabdominelle Fibromatose – Desmoidtumor – Keloid – Ileus – Gardner-Syndrom ; Key words: Extraabdominal fibromatosis – Desmoid tumor – Keloid – Ileus – Gardner's syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract. The report deals with the clinical features of a 26-year-old man with the extraabdominal form of deep fibromatosis, which became manifest at the age of 18 years as acute ileus caused by diffuse intraabdominal fibromatous tumours. In the later course of the disease extensive fibromatous lesions developed, mainly at the skin. In addition, multiple keloids occurred after excision or after negligible traumas. The pathogenetic events of the clinical picture described may be linked to the activation of mesenchymal cells leading to the generation of either fibromatous tumours or posttraumatic keloids.
    Notes: Zusammenfassung. Vorgestellt wird ein 26jähriger Mann mit der extraabdominellen Form einer tiefen Fibromatose, die sich erstmalig im 18. Lebensjahr als akuter Ileus aufgrund ausgeprägter intraabdomineller Bindegewebstumoren manifestierte. Später traten flächenhafte, fibromatöse Bindegewebstumoren bevorzugt an der Haut auf. Neben diesen spontan entstandenen kutan und subkutan gelegenen Hauttumoren fanden sich auch Keloide nach Schnittverletzungen oder Bagatelltraumata an der Haut. Diesem Krankheitsbild liegt möglicherweise eine Aktivierung mesenchymaler Zellen zugrunde, die bei entsprechender Disposition zu fibromatösen Tumoren oder posttraumatischen Keloiden führt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050050
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  • 8
    Electronic Resource
    Electronic Resource
    Methode zur Untersuchung einer Zellsuspension im Schnitt (1959)
    Springer
    Journal of molecular medicine 37 (1959), S. 161-161 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01486786
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  • 9
    Electronic Resource
    Electronic Resource
    Cytochemische Untersuchungen an Liquorzellen bei Meningitis mit einer Bemerkung zur Jodophilie der Leucocyten (1959)
    Springer
    Journal of molecular medicine 37 (1959), S. 1024-1029 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. Cytochemische Untersuchungen an Liquorzellen ergaben beieitriger Meningitis (Meningokokken, Pneumokokken) in Segmentkernigen erhebliche Glykogeneinlagerung und Verminderung des Lipoidgehaltes der Granula, beiseröser Meningitis (Mumps, Poliomyelitis) in Segmentkernigen Lipoidverminderung, in mononucleären Zellen vermehrten Gehalt an basischen Proteinen und Glykogeneinlagerung, beituberkulöser Meningitis in Segmentkernigen Glykogenvermehrung, Lipoidverminderung in den Granula unter leichter paraplasmatischer Sudanophilie, in mononucleären Zellen starke Lipoidbeladung des Cytoplasmas. 2. Ergebnisse an Segmentkernigen wurden im Vergleich mit segmentkernigen, neutrophilen Granulocyten im Blut des erkrankten Kindes und gesunder Individuen ermittelt. Zur Beurteilung mononucleärer Liquorzellen wurden Lymphocyten und Monocyten herangezogen, einerseits da sie morphologisch nächstverwandte Zellen darstellen, andererseits da mittels cytochemischer Kriterien die Herkunft der mononucleären Liquorzellen geprüft werden sollte; in letzterem Zusammenhang ergaben sich viele Gemeinsamkeiten insbesondere mit Lymphocyten. Aber auch diese Ergebnisse erlauben keine definitive Einordnung. 3. Bei den untersuchten Infektionskrankheiten ergeben sich an Leukocyten des peripheren Blutes keine Veränderungen gegenüber der Norm. 4. Sogenannte Jodophilie ist auch an Liquorzellen festzustellen. Cytochemische Methoden beweisen, daß die durch Jod markierte Substanz Glykogen ist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01483210
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  • 10
    Electronic Resource
    Electronic Resource
    Zum Nucleolus-Problem (1957)
    Springer
    Cell & tissue research 46 (1957), S. 18-51 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung 1. Der Nucleolus ist eine chemisch tätige Kernorganelle. Er ist schwammoder knäuelartig aufgebaut, enthält basische und andere Eiweißkörper, ferner RNS. Er ist Feulgen-negativ. Die in ihm gebildeten Substanzen sammeln sich auf seiner Oberfläche. Sie sind ein Nukleolipoproteid und verhalten sich Feulgenpositiv. Für den Stoffabstrom zur Kernmembran stehen mit großer Wahrscheinlichkeit Leitröhren zur Verfügung. Durchtritt durch die Kernmembran erfolgt in der Art eines „Durchschmelzens“. Der Nukleolarapparat der untersuchten Zellen besteht aus dem Nucleolus und den Feulgen-positiven Kerneinschlüssen der verschiedensten Lokalisation. 2. Eine vergleichende Wertung der Befunde der einzelnen Autoren ist nur in beschränktem Umfange möglich, da Material, Methoden und Gesichtspunkte der einzelnen Untersucher erheblich divergieren. Daraus folgt auch, daß eine allgemein gültige Definition des Nucleolus noch nicht gegeben werden kann. Für eine Übergangszeit wird vorgeschlagen, einerseits vonnukleären Blasen — beim Vorliegen unstrukturierter Depots mit Feulgen-positiver Randschale —, andererseits vonNukleolen in engerem Sinne — beim Vorliegen einer strukturierten Kernorganelle — zu sprechen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01106144
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