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  • 1
    Electronic Resource
    Electronic Resource
    Chronic hyperprolactinemia and plasma lipids in women (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 516-519 
    Details
    ISSN: 1432-1440
    Keywords: Chronic hyperprolactinemia ; Plasma lipids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) were studied in 15 hyperprolactinemic women who had a prolactin (PRL) adenoma, in comparison to 15 age-matched control women. In the hyperprolactinemic group, plasma lipids were also correlated to age, excess body weight (EBW), plasma PRL, and estradiol-17β (E2). Plasma TC, TG, and LDL-C were similar in both hyperprolactinemic and control women, while plasma HDL-C was significantly lower (P〈0.01) in the hyperprolactinemic group. The correlation study showed a significant negative correlation between HDL-C and EBW (r=−0.64;P〈0.02) and a slightly significant positive correlation between TG and PRL (r=0.54;P〈0.05). The direct effect of PRL on plasma lipids is difficult to establish since many factors influencing lipid metabolism are altered during hyperprolactinemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01721038
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Serum thyroglobulin levels in hypofunctioning nodules before and after surgery (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 1052-1054 
    Details
    ISSN: 1432-1440
    Keywords: Thyroglobulin ; Hypofunctioning nodules
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serum thyroglobulin (Tg) level was determined in 34 biologically euthyroid patients having benign hypofunctioning nodule, before and after surgery. Based on the results of thyroid scanning with radioiodine, 2 groups of patients were considered. Group 1 (n=18) had solitary hypofunctioning nodule with an otherwise normal thyroid gland and group 2 (n=16) had hypofunctioning nodule inside an enlarged and/or heterogenous thyroid. Results were compared to a group of 30 control subjects. Mean Tg level was significantly elevated in both groups 1 and 2 before surgery. No significant difference was found between group 1 and group 2. After surgical removal of the hypofunctioning nodule (follicular adenoma), mean Tg level was normalized in group 1 and decreased but still remained elevated in group 2. It is concluded that the observed elevated serum Tg level is due to the presence of hypofunctioning nodule and/or heterogenous thyroid tissue. Thus, Tg determination may be useful in the follow-up of operated hypofunctioning nodules in order to detect abnormality in the remaining thyroid tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01739672
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Lack of effect in vivo of clofibrate on adrenal steroid secretion (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 87-89 
    Details
    ISSN: 1432-1041
    Keywords: clofibrate ; hyperlipidaemia ; glucocorticoids ; mineralocorticoids ; progesterone ; aldosterone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Clofibrate inhibits the synthesis of adrenal steroids when administered in vitro. In the present study the effect in vivo of clofibrate on adrenal steroid secretion has been investigated. Basal levels of plasma progesterone, corticosterone, aldosterone, 17-hydroxyprogesterone, 11-deoxycortisol, cortisol, dehydroepiandrosterone sulphate and dehydroepiandrosterone, and their response to ACTH 1 mg im, were not reduced by chronic administration of clofibrate 2 g per day p.o. for 8 to 34 days to 6 hyperlipidaemic men.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561031
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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