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  • 1
    Electronic Resource
    Electronic Resource
    Strain relaxation of Ge films grown on a Si(001)-2×1 surface by molecular beam epitaxy (1990)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 67 (1990), S. 7274-7277 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The crystalline quality of Ge films grown on a Si(100)-2×1 substrate by molecular beam epitaxy has been studied by means of in situ reflection high-energy electron diffraction, x-ray diffraction, and Raman scattering spectroscopy. The Ge layers of thickness up to 4000 A(ring) were deposited at 400 °C with and without thin (200 A(ring)) Ge buffer layers predeposited at 200 °C. It was found that the buffer layers were effective in improving the quality of the thin Ge overlayers, while they had no noticeable effect on the thick layers whose x-ray and Raman spectra were comparable to that of bulk Ge. It was also found that, even after the Ge films became relaxed with a generation of dislocations, they were not free from strain due to the lattice mismatch. This finding is supported by the quantitative estimate of the Raman frequency shift in terms of the uniaxial strain model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.344510
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A novel PTEN mutation in a Japanese patient with Cowden disease (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 142 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cowden disease (CD) is an autosomal dominant syndrome characterized by multiple hamartomatous lesions and an increased risk for malignancies. Recent evidence has indicated that the PTEN gene, encoding a protein tyrosine phosphatase, is the CD susceptibility gene. However, another line of evidence has suggested that CD might be genetically heterogeneous. Clinical features of CD are variable, and there are interfamilial differences in the expression of skin lesions . Therefore, information on PTEN mutations in CD patients should be accumulated to clarify the genotype–phenotype correlation. In the present study, we found heterozygous germline mutations of PTEN in all of three Japanese patients with CD examined, indicating no genetic heterogeneity among our patients. The mutations included two non-sense mutations of R335X and R130X, and a mis-sense mutation of C136R. To the best of our knowledge, the C136R mutation has not previously been reported in CD patients. This novel mutation was located outside the core motif of the phosphatase domain of PTEN protein, where most of the missense mutations previously reported in CD patients were clustered. Mucocutaneous manifestations were far fewer in the patient with this mutation than in the patients with nonsense mutations. Whether the phenotypic difference in mucocutaneous features was due to the different mutations remains unclear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03533.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Forensic analysis of triazolam in human tissues using capillary gas chromatography (1991)
    Springer
    International journal of legal medicine 104 (1991), S. 67-69 
    Details
    ISSN: 1437-1596
    Keywords: Triazolam ; Estazolam ; Capillary GC/NPD ; Human tissue ; Forensic toxicology ; Triazolam ; Estazolam ; Kapillar-Gaschromatographie/NPD ; Menschliches Gewebe ; Forensische Toxikologie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Eine zuverlässige und empfindliche Methode wurde entwickelt, um die Konzentrationen des hypnotischen Medikaments Triazolam in menschlichen Geweben, einschließlich fauler Gewebe bestimmen zu können. Die Methode besteht aus einer dreistufigen Flüssig-Flüssig-Extraktion, einem Clean up an Kieselgel und Gaschromatographie mit einem Stickstoff-PhosphorDetektor und einer Kapillarsäule. Als interner Standard wurde Estazolam benutzt. Die Eichkurve war im Konzentrationsbereich zwischen 1 ng/g und 1 gg/g linear, und die untere Nachweisgrenze betrug 0.5 ng/g. Es wurde eine forensische Untersuchung über die toxikologischen Effekte von Triazolam an faulem Gewebe durchgeführt.
    Notes: Summary A reliable and sensitive method has been developed to assess the concentrations of the hypnotic drug triazolam in human tissues, including putrefied tissues. The method involves a 3-step solvent extraction, cleanup on a silica gel column and gas chromatography using a nitrogen phosphorus detector and a capillary column. Estazolam was used as an internal standard. The calibration curve was linear over the concentration range 1 ng/g1 gm/g and the lower limit of detection was 0.5 ng/g. A forensic study was performed on the toxicological effects of triazolam using putrefied tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01626033
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Identification of beverages and beverage stains by GC/MS using aroma components as indicators (1997)
    Springer
    International journal of legal medicine 111 (1997), S. 13-16 
    Details
    ISSN: 1437-1596
    Keywords: Key words Beverage ; Aroma components ; Porous ; polymer beads ; GC/MS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract A method to identify brown coloured beverages or beverage stains for criminological purposes was devised using aroma components as indicators. The examined beverages comprised three brands each of beer, coffee, cola and black tea, two brands of oolong tea, and four brands of green tea. Aroma components in each sample were efficiently concentrated with a porous polymer beads column (Porapak Q) and were analyzed by gas chromatography/mass spectrometry (GC/MS) using n-octyl alcohol as the internal standard. Specific aroma components were found in each beverage and beverage stain, for example cis-terpin hydrate in cola, and thus identification of beverages or beverage stains became feasible through the detection of these specific components. The present method was applied efficiently to two practical criminological cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004140050103
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    Paper (German National Licenses)
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