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  • 1
    Electronic Resource
    Electronic Resource
    Antagonism by haloperidol of the suppression of exploratory locomotor activity induced by the local application of(−)3-(3-hydroxyphenyl)-N-n-propylpiperidine into the nucleus accumbens of the rat (1984)
    Springer
    Cellular and molecular life sciences 40 (1984), S. 858-859 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The injection of (−)3-PPP into the nucleus accumbens, 10 μg/side, produced a suppression of exploratory locomotor activity without affecting treadmill locomotion. Furthermore, the suppression of exploratory locomotor activity produced by (−)3-PPP was antagonized by the administration of haloperidol, 25–50 μg/kg i.p.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951994
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    High doses of oxytocin cause sedation and low doses cause an anxiolytic-like effect in male rats
    Amsterdam : Elsevier
    Pharmacology, Biochemistry and Behavior 49 (1994), S. 101-106 
    Details
    ISSN: 0091-3057
    Keywords: Anxiolytic-like effect ; Locomotor activity ; Oxytocin ; Sedation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0091-3057(94)90462-6
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Partial protection against hyperbaric oxygen induced convulsions by dopaminergic agents in mice: Possible involvement of autoreceptors? (1987)
    Springer
    Journal of neural transmission 69 (1987), S. 277-285 
    Details
    ISSN: 1435-1463
    Keywords: Seizures ; hyperbaric oxygen ; dopamine ; autoreceptors ; mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the present report we have investigated the effects of apomorphine, (−)3-PPP,L-DOPA and haloperidol on the elicitation of convulsions induced in mice by exposure to oxygen at high pressure (HBO) (5 ata O2). It was found that the administration of apomorphine (0.025–0.1 mg · kg−1 s. c.), (−)3-PPP (4 mg · kg−1 i. p.)L-DOPA (200–400 mg · kg−1 i. p.) as well as halo-peridol (0.25–2.0 mg · kg−1 i. p.) produced a significant protection against HBO-induced convulsions. Haloperidol was the only drug to produce a dose-dependent decrease in respiration, and this effect does probably explain the anticonvulsant effects observed. The low doses at which apomorphine was effective, and the effects produced by (−)3-PPP, indicate an effect mediated via DA autoreceptors. Alternatively, and more likely taking the effects ofL-DOPA into account, the DA receptors involved are sensitive enough to disclose postsynaptic agonist properties of apomorphine and (−)3-PPP at the doses employed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244348
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of 5-HT and 8-OH-DPAT on forebrain monoamine synthesis after local application into the median and dorsal raphe nuclei of the rat (1990)
    Springer
    Journal of neural transmission 81 (1990), S. 131-145 
    Details
    ISSN: 1435-1463
    Keywords: 5-HT ; 8-OH-DPAT ; intracerebral application ; raphe nuclei ; tryptophan hydroxylase ; tyrosine hydroxylase ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 5-HT (10 and 40 Μg) and 8-OH-DPAT (1 and 5 Μg) were locally applied into the dorsal or median raphe nuclei in awake, unrestrained, rats. All animals were also treated with the 5-HTP and DOPA decarboxylase inhibitor NSD-1015, 100mg kg−1 SC, 30 min before decapitation. 5-HT or 8-OH-DPAT were administered 5 min before NSD-1015. The regional brain in vivo rate of tyrosine and tryptophan hydroxylase activity was estimated by measuring the accumulation of DOPA and 5-HTP. The following brain regions were sampled: neocortex, hippocampus, dorso-lateral neostriatum, ventro-medial neostriatum, nucleus accumbens, olfactory tubercle, globus pallidus, septum and the amygdala. Compared to normal controls, there were small and inconsistent effects on forebrain 5-HTP accumulation by saline injections into the dorsal or the median raphe (an increase in 3 out of 36 experiments), whereas strong effects by the injection procedure were noted on forebrain DOPA accumulation (an increase in 15 out of 36 experiments). Injections of 5-HT (same effect by 10 or 40 Μg) into the dorsal raphe, produced a decrease in 5-HTP accumulation in all forebrain areas except for the hippocampus and the septum, whereas no effects were seen in any area after median raphe injections. In contrast, 8-OH-DPAT preferentially produced a decrease in forebrain 5-HTP accumulation after median raphe injections and less, but statistically significant effects by dorsal raphe injections. The 8-OH-DPAT injection into the median raphe primarily affected limbic forebrain areas (hippocampus, nucleus accumbens, ventro-medial neostriatum, amygdala and the septum). This dissociation of the effects of 5-HT and 8-OH-DPAT on forebrain 5-HT synthesis after local application into the dorsal or the median raphe strongly supports the contention of heterogeniety in the brain 5-HT receptor population in terms of receptor subtypes and/or receptor regulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01245833
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Behavioral and biochemical effects of subchronic treatment with (−)3-(3-hydroxyphenyl)-N-n-propylpiperidine in the rat: Dopamine receptor sensitivity and tolerance (1984)
    Springer
    Journal of neural transmission 60 (1984), S. 103-113 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Male Sprague-Dawley rats were treated for 3 weeks with (−)3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP). Twenty-four hours, but not 72 hours, after withdrawal of the treatment there was an increase in locomotor activity in comparison with saline treated controls. At the same time there was a decrease in striatal DOPAC and HVA and an increased locomotor activity response to apomorphine, indicating supersensitive dopamine receptors. There was no evidence for behavioral tolerance since the suppression of locomotor activity after an acute dose of (−)3-PPP was the same in (−)3-PPP-pretreated as in saline-treated controls. Plasma levels of (-)3-PPP in these animals were, however, slightly decreased.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01245028
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of (-)3-PPP on acquisition and retention of a conditioned avoidance response in the rat (1984)
    Springer
    Psychopharmacology 84 (1984), S. 441-445 
    Details
    ISSN: 1432-2072
    Keywords: Conditioned avoidance ; Dopamine autoreceptors ; 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP) ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The administration of (-)3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP) was found to partially, but significantly, suppress the acquisition (4–8 mg/kg IP) and performance (8–16 mg/kg IP) of a conditioned avoidance response (CAR) in male Sprague-Dawley rats. All statistically significant effects were observed within 2 h of injection. Furthermore, using a situation in which the CAR was dependent on a visual successive discrimination, it was shown that discriminative performance was unaffected, and that (-)3-PPP (12.5–25 mg/kg IP) but not (+)3-PPP, suppressed the CAR. When (-)3-PPP (6.25 mg/kg IP) was combined with haloperidol (0.1–0.4 mg/kg IP), additive effects on the CAR performance were observed. Considering these effects, and the doses of (-)3-PPP required to suppress the CAR performance, it is concluded that the effects obtained in the present experiments are primarily due to a blockade of postsynaptic DA receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431447
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    Paper (German National Licenses)
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