ISSN:
1435-1463
Keywords:
Seizures
;
hyperbaric oxygen
;
dopamine
;
autoreceptors
;
mice
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In the present report we have investigated the effects of apomorphine, (−)3-PPP,L-DOPA and haloperidol on the elicitation of convulsions induced in mice by exposure to oxygen at high pressure (HBO) (5 ata O2). It was found that the administration of apomorphine (0.025–0.1 mg · kg−1 s. c.), (−)3-PPP (4 mg · kg−1 i. p.)L-DOPA (200–400 mg · kg−1 i. p.) as well as halo-peridol (0.25–2.0 mg · kg−1 i. p.) produced a significant protection against HBO-induced convulsions. Haloperidol was the only drug to produce a dose-dependent decrease in respiration, and this effect does probably explain the anticonvulsant effects observed. The low doses at which apomorphine was effective, and the effects produced by (−)3-PPP, indicate an effect mediated via DA autoreceptors. Alternatively, and more likely taking the effects ofL-DOPA into account, the DA receptors involved are sensitive enough to disclose postsynaptic agonist properties of apomorphine and (−)3-PPP at the doses employed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01244348
