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  • 1
    Electronic Resource
    Electronic Resource
    Sclerosing fibrous tumor of the cauda equina: a fibroblastic variant of peripheral nerve tumors? (1993)
    Springer
    Acta neuropathologica 86 (1993), S. 193-197 
    Details
    ISSN: 1432-0533
    Keywords: Fibroma ; Cauda equina ; Peripheral nerve tumor ; Immunohistochemistry ; Ultrastructural study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The case of a 43-year-old man with an unusual mesenchymal tumor of the cauda equina is presented. A well-circumscribed firm tumor was found in the lower spinal canal at L1 level. Although a nerve root was involved, the adjacent dura mater or filum terminale was unrelated to the tumor. Microscopically, the tumor was rich in collagen and made up of irregularly intertwining fascicles of fibroblastic spindle cells lacking in nuclear atypia or mitotic activity. Partial broad hyalinization of collagen was another histological feature of the tumor. Histological and immunohistochemical studies failed to reveal any findings that suggested known fibrous neoplasms, such as schwannoma, neurofibroma and meningioma, originating in the nervous system. Ultrastructural features of the tumor cells were consistent with those of fibroblasts. Hence, the present tumor is regarded as a unique pure fibroblastic tumor (fibroma) derived from the interstitium of a nerve root in the cauda equina.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334890
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  • 2
    Electronic Resource
    Electronic Resource
    Cytokeratin expression of apocrine and eccrine poromas with special reference to its expression in cuticular cells (2000)
    Copenhagen : Munksgaard International Publishers
    Journal of cutaneous pathology 27 (2000), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: There are no immunohistochemical studies on cytokeratin (CK) expression in large series of cases of apocrine poroma. In addition, detailed immunohistochemical analysis of cuticular cells, a specific type of constituent cells of poromas, has not been reported.Methods: Using the avidin-biotin method, we compared immunostaining patterns of eleven different anti-CK antibodies in 12 cases of apocrine and 21 cases of eccrine poromas, and normal adult skin.Results: Poroid cells were exclusively positive for CK1/5/10/14, CK5/8 and CK14, which were expressed in the outer cells of normal dermal sweat ducts. Poroid cells were heterogeneously stained with anti-CK7, CK8/18, CK10/11 and CK19 antibodies, which reacted in the inner cells of dermal ducts and in the secretory cells of sweat glands. The cuticular cells showed constant expression of CK1/5/10/14 and CK10/11, and various expression patterns of CK5/8, CK6, CK7, CK14, CK8/18, CK17, and CK19.Conclusions: Based on the keratin immunohistochemistry, the neoplastic cells in eccrine and apocrine poromas are considered to be closely related to the cells of dermal sweat ducts. Also the cuticular cells are considered to occupy an intermediate spectrum between the inner and outer cells of the dermal ducts. Although it is difficult to differentiate apocrine poroma from eccrine poroma by keratin expression patterns alone, the data obtained here can be helpful in differentiation of apocrine poroma from other hair follicle-related neoplasms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0560.2000.027007367.x
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  • 3
    Electronic Resource
    Electronic Resource
    A rippled-pattern trichoblastoma: an immunohistochemical study (2000)
    Copenhagen : Munksgaard International Publishers
    Journal of cutaneous pathology 27 (2000), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Since the first description by Hashimoto et al., there have been only a few case reports of rippled-pattern tricogenic tumor. In addition, there are no reports on detailed immunohistochemical analyses of this rare neoplasm. We describe here an additional case of rippled-pattern trichogenic tumor with a special reference to its immunohistochemical features.Methods: A nodule arising on the occipital area of a 62-year-old Japanese woman was histologically and immunohistochemically investigated.Results: Histopathologically, the lesion contained various-sized lobular nests, which consisted of oval to elliptical shaped basaloid cells without any atypia and were embedded in the collagenous stroma. Some elongated basaloid cells were arranged in a palisading fashion forming parallel rows of epithelial ribbons in a rippled-pattern. Cytokeratin (CK) immunohistochemistry showed constant expressions of CK1/5/10/14, CK5/8, CK14 and CK7, and focal expressions of CK17 and CK19 in the basaloid cells, suggesting a keratin phenotypical similarity to the cells in small nodular type trichoblastoma.Conclusions: The present tumor is a variant of trichoblastoma, and considered to be in close association with the outer root sheath and/or follicular germinative cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0560.2000.027009460.x
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  • 4
    Electronic Resource
    Electronic Resource
    Peripheral primitive neuroectodermal tumour with ganglioneuroma-like areas arising in the cauda equina (1997)
    Springer
    Virchows Archiv 431 (1997), S. 365-369 
    Details
    ISSN: 1432-2307
    Keywords: Key words Primitive neuroectodermal tumour ; Ganglion cell ; Cauda equina ; EWS/FLI-1 gene ; MIC2 gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Peripheral primitive neuroectodermal tumour (pPNET or peripheral neuroepithelioma) is one of the malignant small round cell tumours of peripheral nerves, soft tissues and bones, but rarely originates in the spinal canal. We report an example of pPNET arising in the cauda equina of a 14-year-old Japanese boy. At surgery, a well-demarcated tumour measuring 2×4 cm in diameter and involving one of the nerve roots of the cauda equina was located within the intradural space with no evidence of extradural extension. Microscopically the tumour was made up of sheets of closely packed small round cells, associated with ganglioneuroma-like islands. Immunohistochemically, the small round tumour cells were intensely positive for neuron-specific enolase (NSE), an MIC2 gene product (O13) and β2-microglobulin, whereas the foci with ganglion cell-like cells reacted positively to NSE, synaptophysin and β2-microglobulin but were negative for O13. A chimeric transcript of the EWS/FLI-1 fusion gene detected by a nested reverse transcriptase–polymerase chain reaction using formalin-fixed paraffin-embedded tissue justified the diagnosis of pPNET. Only 6 cases of PNET in the cauda equina have been described in the literature, and this is the first case of a pPNET with ganglioneuroma-like areas. This finding suggests that the primitive tumour cells of pPNET may respond to unknown inductive effects and express a ganglion cell-like morphology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050112
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  • 5
    Electronic Resource
    Electronic Resource
    Dermatofibrosarcoma protuberans with fibrosarcomatous areas (1998)
    Springer
    Virchows Archiv 433 (1998), S. 323-329 
    Details
    ISSN: 1432-2307
    Keywords: Key words Dermatofibrosarcoma protuberans ; Fibrosarcoma ; p53 ; mdm2 ; p21
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Fibrosarcomatous (FS) change in a rare, but well-known phenomenon encountered in dermatofibrosarcoma protuberans (DFSP), and an increased chance in an adverse outcome has been suggested in patients with DFSP having FS areas (DFSP-FS). As altered p53 pathway has been suggested as having a potential role in tumour progression, we analysed the p53 gene and p53 protein together with the p53-related protein mdm2 and p21Wafl in 5 cases of DFSP-FS and 13 of DFSP to ascertain whether the p53 pathway correlates to the fibrosarcomatous transformation of DFSP. Three of the five DFSP-FSs overexpressed p53 protein immunohistochemically, and one of them had a ”missense” mutation of the p53 gene without immunohistochemical overexpression of mdm2 or p21Wafl. The other two DFSP-FSs with p53 overexpression demonstrated increased labelling indices of both mdm2 and p21Wafl. The three DFSP-FS patients with overexpression of p53 protein had frequent local recurrences, ranging from 3 to 5 in number with increasingly short intervals (mean 4.5 years), while one of the other two had no recurrences and the other, only one. None of the 13 DFSPs showed any alterations in the p53 gene or overexpressions of p53, mdm2 and p21Wafl, except for one DFSP having a ”silent” mutation of the p53 gene. Three DFSPs had local recurrences once or twice with longer intervals to recurrence (mean 10.3 years). Although the number of cases examined is limited, the results suggest that alterations in the p53 pathway, such as overexpression of p53 protein by a mutated gene and mdm2 overexpression, are involved in fibrosarcomatous transformation in a subset of fibrohistiocytic tumours and possibly correlated with its more locally aggressive behaviour than that without p53 alterations or ordinary DFSP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050256
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  • 6
    Electronic Resource
    Electronic Resource
    Activating Gsα mutation in intramuscular myxomas with and without fibrous dysplasia of bone (2000)
    Springer
    Virchows Archiv 437 (2000), S. 133-137 
    Details
    ISSN: 1432-2307
    Keywords: Key words  Gsα ; Intramuscular myxoma ; Fibrous dysplasia ; Mazabraud’s syndrome ; McCune-Albright syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Activating missense mutations in the Arg 201 codon of the gene encoding the α subunit of Gs, the G protein that stimulates cAMP formation, have been recognized as the cause of many endocrine diseases, McCune-Albright syndrome and isolated fibrous dysplasia of bone. On the other hand, intramuscular myxomas with fibrous dysplasia, so-called Mazabraud’s syndrome, have been sporadically reported, but it has not been confirmed whether intramuscular myxoma, with or without fibrous dysplasia, is associated with the Gsα mutations. We investigated the presence of the Gsα mutations in intramuscular myxomas with or without fibrous dysplasia by a PCR-SSCP assay, using formalin-fixed, paraffin-embedded tissues. In five of the six intramuscular myxomas (three with and two without fibrous dysplasia), point mutations were detected as aberrant bands by SSCP, which were confirmed by a subsequent sequence analysis (three Arg to His and two Arg to Cys). This result suggests that the Gsα mutations are related to tumorigenesis in intramuscular myxoma and that intramuscular myxoma is one of the diseases induced by abnormal Gsα protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280000217
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  • 7
    Electronic Resource
    Electronic Resource
    Giant degenerative perineurial cell tumor (1996)
    Springer
    Skeletal radiology 25 (1996), S. 757-761 
    Details
    ISSN: 1432-2161
    Keywords: Key words Perineurioma ; Perineurial cell tumor ; Neurilemoma ; Peripheral nerve sheath tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We report a case of giant perineurial cell tumor, probably benign, with extensive degenerative changes. The secondary changes were reminiscent of those in giant ancient neurilemomas. To our knowledge, there has been no documention of the imaging features in perineurioma. The MR findings of the present tumor, especially on T2-weighted images, correlated well with the histologic appearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002560050174
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  • 8
    Electronic Resource
    Electronic Resource
    Maffucci’s syndrome associated with spindle cell hemangioendothelioma (1997)
    Springer
    Skeletal radiology 26 (1997), S. 191-194 
    Details
    ISSN: 1432-2161
    Keywords: Key words Maffucci’s syndrome ; Spindle cell hemangioendothelioma ; Enchondromatosis ; Hemangioma ; Histopathology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The case of a 49-year-old man with Maffucci’s syndrome, who developed multiple spindle cell hemangioendotheliomas, is presented. The case provides support for recent reports suggesting an association between this peculiar vascular lesion and skeletal enchondromatosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002560050219
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  • 9
    Electronic Resource
    Electronic Resource
    Intraosseous microcystic meningioma (2000)
    Springer
    Skeletal radiology 29 (2000), S. 354-357 
    Details
    ISSN: 1432-2161
    Keywords: Key words Intraosseous meningioma ; Microcystic meningioma ; Parietal bone ; X ray ; CT ; MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Extradural ectopic meningioma is a rare tumor. We report on an example of microcystic meningioma arising in the skull of an elderly woman. Radiological examination revealed a localized osteolytic lesion in the left parietal bone. At surgery, it was discovered that the tumor was located within the skull without any evidence of extraosseous extension. The light microscopic, immunohistochemical and ultrastructural features were consistent with a microcystic variant of meningioma. To our knowledge, this is the first case of an intraosseous microcystic meningioma, and we believe that this type of meningioma should be considered in the differential diagnoses of myxoid bone tumors of the calvarium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002560000217
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