ISSN:
1432-1246
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The excretion of p-nitro-m-cresol and changes in the activity of cholinesterase in volunteers were studied after single and repeated doses of fenitrothion. Fenitrothion in single doses was given in quantities of 2.5, 5, 10, 15 and 20 mg. Practically the whole quantity of p-nitro-m-cresol was discharged within the first twentyfour hours after administration, the maximum excretion being within the first 12 hours. The quantity of p-nitro-m-cresol was proportional to the dose of fenitrothion, but expressed as a percentage of theoretical quantity depends, to a certain extent, on the size of the dose administered. After receiving doses of 2.5 mg of fenitrothion the people tested discharged on an average 70.4±3.4 % of p-nitro-m-cresol; after doses of 5 mg 58.7±8.7 % ; after 10 mg 51.9±5.6 % ; after 15 mg 49.5 ± 1.9 % ; after 20 mg 48.1 ± 7.6 %. A statistically significant difference in the discharge of p-nitro-m-cresol is to be found only between the dose 2.5 mg and the doses 10, 15 and 20 mg of fenitrothion. The plasma and red cell cholinesterase activity, with one exception, did not drop below the limit of normal variations among individuals. Repeated doses of fenitrothion were given in 24 hours' intervals, in doses of 4 × 2.5 mg and 4 × 5 mg. The p-nitro-m-cresol was determined in urine collected 0 to 12 and 12 to 24 hours after administration. Almost the entire quantity of p-nitro-m-cresol was excreted in the intervals from 0 to 12 hours. No signs of cumulation of fenitrothion appeared. The activity of red cell cholinesterase, after the 3rd and 4th dose of fenitrothion showed a moderately rising tendency. From the results obtained with single and repeated doses of fenitrothion administered to persons experimented on it follows that exposure to fenitrothion which does not yet cause a drop in the activity of cholinesterase can reliably be proved on the basis of the discharge of p-nitro-m-cresol in the urine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00404665
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