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  • 1
    Electronic Resource
    Electronic Resource
    Die Größe des akuten tierexperimentellen Herzinfarktes unter Streptokinase-induzierter Fibrinolyse (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 755-760 
    Details
    ISSN: 1432-1440
    Keywords: Coronary occlusion ; epicardial mapping ; infarction size ; fibrinolysis ; Streptokinase ; fibrinogen degradation products ; Coronarocclusion ; epicardiales EKG ; Infarktgröße ; Fibrinolyse ; Streptokinase ; Fibrinogen-Spaltprodukte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 17 narkotisierten Hunden wurden mehrere Seitenäste des Ramus descendens der linken Kranzarterie unterbunden. Die ST-Segmentelevation im epikardial abgeleiteten EKG stieg dabei bis auf 22 mV nach 5 min und 19 mV nach 20 min an. Aortendruck, enddiastolischer Druck im linken Ventrikel, Herzfrequenz und die hämostasiologischen Parameter (Plasmathrombinzeit, Thrombinkoagulasezeit, Reptilasezeit, Plasmafibrinogen, Staphylokokken-Clumping-Test) änderten sich nicht. 20 min nach Beginn der Okklusion wurden die Gefäße geöffnet. Nachdem sich die St-Segmenthebung zurückgebildet hatte, wurde eine kontrollierte Fibrinolyse (Streptokinase 1,5 Mega I.E. in 30 min initial, Fortführung mit 0,75 Mega I.E./h) eingeleitet. Wenn die hämostasiologischen Parameter eine effektive Lyse anzeigten, wurden die gleichen Gefäße erneut unterbunden. Auch jetzt änderten sich die hämodynamischen Größen nicht wesentlich. Die ST-Segment-Elevation war jedoch signifikant um 50% geringer als nach einfacher Ligatur. Eine Kontrollgruppe, die nur das Lösungsmittel der Streptokinase erhielt, zeigte dagegen einen unveränderten Anstieg der ST-Streckenelevation. Die Wirkung der Streptokinase wird auf das Auftreten von Fibrinogen-Spaltprodukten und die Senkung des Fibrinogenspiegels zurückgeführt, die eine Verbesserung der Mikrozirkulation hervorrufen.
    Notes: Summary In 17 unaesthetized dogs several side branches of the left descending coronary artery were ligated. The ST-segment elevation in the epicardial ECG ascended to 22 mV after 5 min and to 19 mV after 20 min. Aortic pressure, left ventricular enddiastolic pressure, heart rate and hemostasiological parameters (thrombin-time, thrombin-coagulase-time, reptilase-time, plasma-fibrinogen, staphylococcal clumping test) did not change significantly. 20 min after the beginning of coronary occlusion, the vessels were reopened. When ST-segment elevation had disappeared, a controlled fibrinolytic therapy (Streptokinase 1.5 Mega I.E. in 30 min, later on 0.75 Mega I.E./h) was induced. When an effective fibrinolysis could be demonstrated by the hemostasiological parameters, the same vessels were occluded again. Now the hemodynamic parameters too did not change significantly, but the ST-segment elevation was significantly diminished for more than 50% compared with simple ligation. A control group, which only got the solvent of the streptokinase, showed the same ST-segment elevation. This effect, induced by streptokinase is ascribed to fibrinogen degradation products and a diminution in the amount of fibrinogen which cause an improvement of microcirculation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01614856
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  • 2
    Electronic Resource
    Electronic Resource
    Die Wirkung von Furosemid und Etacrynsäure auf die Kohlenhydrat- und Fettsäureaufnahme und auf den Glykogengehalt der Hundeniere in vivo (1971)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 270 (1971), S. 117-135 
    Details
    ISSN: 1432-1912
    Keywords: Renal Metabolism ; Glucose ; Lactate ; Pyruvate ; Non-esterified Fatty Acids ; Glycogen ; Furosemide ; Ethacrynic Acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The following parameters have been determined in anesthetized dogs: Urine volume (UV), GFR, renal blood flow (RBF), sodium excretion (ENa), tubular sodium reabsorption (TNa), the arterial and renal venous concentration,a- v difference and renal net uptake of glucose, lactate, pyruvate, and nonesterified fatty acids (FFA). After control periods, 5 mg/kg furosemide or ethacrynic acid have been injected intravenously. Tissue concentrations of glycogen in cortex and medulla have been compared before and after administration of the two diuretics. Both, furosemide and ethacrynic acid had comparable effects on UV, GFR, ENa and TNa at the doses given. The mean increase of RBF was 34% after ethacrynic acid and 23% after furosemide. The net uptake of the substrates in 68 control measurements in 17 dogs averaged 60.0±6.2 for lactate, 5.0±0.8 for pyruvate and 15.0±2.1 for FFA (μmol/min · 100 g kidney weight). The correlation of arterial load and net uptake was significant for lactate and FFA. In- and outflow of glucose were not significantly different. There was no net uptake of glucose even after a 4–5 fold increase of the arterial concentration by an i.v. infusion of glucose. Neither furosemide nor ethacrynic acid had an effect on renal glucose balance. Both blocked the renal uptake of FFA completely. After furosemide the uptake of lactate and pyruvate averaged only about one half of the respective controls whereas there was a net release of both substrates after ethacrynic acid. The glycogen concentration of the renal cortex amounted to 0.48 mmol glucose/kg wet weight in renal cortex and to 1.40 in medulla. Both diuretics increased tissue glycogen concentration by 20–25%. One can conclude that both, furosemide and ethacrynic acid, inhibit the oxidative metabolism in renal cortex whereas anaerobic glycolysis is less or not affected. The results are discussed with regard to the constant oxygen consumption which has been observed in previous experiments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00997083
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  • 3
    Electronic Resource
    Electronic Resource
    Verbrauchskoagulopathie bei Carcinomen des Kopf- und Halsbereiches (1974)
    Springer
    European archives of oto-rhino-laryngology and head & neck 207 (1974), S. 563-565 
    Details
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Chronical consumption — coagulopathy appears in patients suffering on carcinomas, especially in cases of widespread metastases. Life threatening complications develop particularly in phases of bonemarrow depletion (tumor-caused; therapy-caused). Besides of hemorrhagical bleeding and disturbances of wound-heeling by poor fibrine stabilisation (lack of clotting factor 13) the consequence of clotting in the “Endstrombahn” by thrombocytes micro aggregates stands in the foreground. The hereby caused deterioriation of blood flow dynamic can lead to heavy disturbance of the pulmonary circulation system. An effective therapy is available in minimum low heparin doses. Antifibrinolytic agents are contraindicated, except of simultaneous heparin application.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00464205
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    Paper (German National Licenses)
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