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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 29 (1957), S. 438-441 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 24 (1952), S. 2020-2020 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1106
    Keywords: Key words Enkephalin ; GABA ; Basal ganglia ; 6-Hydroxydopamine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In Parkinson’s disease the dopaminergic nigrostriatal pathway degenerates, resulting in an imbalance in activity of two pathways of information flow through the basal ganglia. In animal models of the disease, the striatonigral pathway becomes underactive and the striatopallidal pathway becomes overactive. In the present study immunocytochemistry for enkephalin and GABA and anterograde labelling were used to investigate whether morphological plasticity occurs in striatopallidal terminals following unilateral removal of the nigrostriatal dopaminergic pathway. Pallidal terminals were immunostained to reveal enkephalin and examined in the electron microscope (n=399). Immunoreactive synaptic bouton profiles were on average 64% larger on the experimental side 26 days after the lesion. Analysis of their shape revealed that those on the dopamine-depleted side of the brain were more irregular in profile and that their synaptic specialisations were more complex in shape but not significantly different in length. Striatopallidal terminals were also identified by GABA immunocytochemistry combined with anterograde labelling (n=20). Double-labelled boutons were significantly larger in cross-sectional area on the experimental side (57%). Analysis of terminals that were simply labelled by the immunogold method to reveal GABA (n=278) showed no significant differences in size between terminals from the dopamine-depleted and control side. This suggests that a substantial number of GABAergic terminals in the globus pallidus do not belong to the striatopallidal population of terminals. These morphological changes correlate with previous studies suggesting striatopallidal boutons are more active after destruction of dopaminergic input to the neostriatum.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 53 (1988), S. 0 
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Lactobacillus acidophilus was suspended in broth and buffer at pH 2, 3 and 4 and incubated at 37°C for 2 hr. In both broth and buffer pH 2, viable cell numbers decreased rapidly, and none were recovered after 45 min. At pH 4 in broth and buffer, the number of cells was not significantly reduced in 2 hr. In potassium phthalate buffer at p 3, no viable cells were recovered after 30 min, while in KCl buff and broth at pH 3, no significant reduction was seen. Cells subjected to low pH for up to 5 h were able to adhere to human intestinal cells in vitro. Exposure to low pH did not appear to disrupt the ruthenium red staining layer exterior to the cell wall.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 15 (1943), S. 527-533 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Health & social care in the community 6 (1998), S. 0 
    ISSN: 1365-2524
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Most research on children and risk is heavily influenced by developmental theory. This paper is based on a study which uses a different approach, drawing on recent work within the sociology of childhood. ‘Children, Parents and Risk’ explores the ways in which risks to children are understood and managed by children and parents, focusing on children's daily lives in and around the home at the ages of 3, 9 and 12 years. Data were gathered from interviews with children and their parents at home and from children at school and in a youth club. The paper draws on the findings from the study in order to discuss and compare parents' and children's ideas about children and childhood as risk-related; it also aims to examine the findings in the context of Ulrich Beck's recent work on the risk society and individualization. Both parents and children tended to ‘externalize’ risk away from the home and into the outside world. In response to perceived risks to childhood many parents appeared to see their role as that of striking a balance between protection and compensatory provision, and their accounts included details of increasingly ‘individualized’ measures to reduce such risks. The children conceptualized their experiences of adult control as welcoming when preventing the child's exposure to risk but as constraining when it restricted their autonomy. The paper concludes that the findings accord with Beck's description of the ‘risk society’ and that they lend some limited support to Beck's individualization thesis.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial & engineering chemistry 8 (1916), S. 709-711 
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 52 (1987), S. 0 
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were used to observe the means by which three strains of Lactobacillus acidophilus adhere to surfaces. When observed with SEM, all strains adhered to glass coverslips; however, no attachment fibrils were seen. When viewed with TEM, strain BG2F04 showed a polysaccharide (PS) material outside the cell wall. This strain had previously been shown to adhere strongly to human intestinal tissue cells, while strain Lac 12 had shown weak adherence, and strain NCFM did not adhere. The PS layer on strain Lac 12 was variable, and a PS layer on NCFM could not be seen. These observations suggested that this PS material may be involved in the adherence of strain BG2F04 to surfaces.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1106
    Keywords: Basal ganglia ; Nigrostriatal pathway ; Plasticity ; Dendritic spines ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Destruction of the dopamine-containing neurons in the rat substantia nigra results in morphological changes in the striatum which have been characterized at both the light and electron microscopic levels. After a unilateral 6-hydroxydopamine injection into the medial forebrain bundle, Golgi-impregnated medium-sized spiny neurons in the neostriatum ipsilateral to the injection had a lower density of spines on their dendrites than those on the contralateral side. A similar decrease in spine density was apparent from 12 days until at least 13.5 months after the lesion. A bilateral loss of spines occurred with increasing age regardless of the presence or absence of the nigrostriatal dopaminergic pathway. At the ultrastructural level, the general pattern of synaptic input to the Golgi-impregnated medium-sized spiny neurons was similar on both sides of the brain. The most obvious class of afferent boutons contacting these spiny neurons formed prominent asymmetrical synaptic specializations with the heads of the spines. The numbers of asymmetric synaptic profiles counted in random electron micrographs from the striata ipsilateral and contralateral to the lesion were not significantly different from each other. A small but significant increase in the length of asymmetric synaptic specialization profiles was, however, detected in the striata lacking a dopamine input.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical microbiology & infectious diseases 16 (1997), S. 261-280 
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Resistance ofCandida to azoles is an increasing problem. Susceptibility testing ofCandida against fluconazole and ketoconazole is now feasible and desirable. Good correlation of resistance in vitro with clinical failure of fluconazole therapy has now been shown in mucosal candidiasis. The relationship, if any, between resistance and clinical failure in the context of invasive candidiasis is not clear at present and additional correlative work needs to be done. Monitoring of resistance trends inCandida is clearly important now.
    Type of Medium: Electronic Resource
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