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  • 1
    Electronic Resource
    Electronic Resource
    Possible association of NADPH-cytochrome P-450 reductase and cytochrome P-450 in reconstituted phospholipid vesicles (1983)
    s.l. : American Chemical Society
    Biochemistry 22 (1983), S. 3586-3594 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00284a008
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrastructure and morphometry of testicular Leydig cells and the interstitial components correlated with testosterone in aging rats (1993)
    Springer
    Cell & tissue research 271 (1993), S. 241-255 
    Details
    ISSN: 1432-0878
    Keywords: Leydig cell ; Testis ; Interstitium ; Aging ; Ultrastructure ; Morphometry ; Testosterone ; Rat (Wistar)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The ultrastructure of testicular interstitium in young and aged adult rats was analysed using morphometric methods, and the plasma testosterone concentration was measured. With increasing age there was an augumentation in the volume of collagen fibrils in the intercellular matrix and in blood vessels. During the aging process (approximately two years) the average volume of the Leydig cell decreased from 1364 μm3 to 637 μm3, but the number of Leydig cells in paired testes increased from 53x106 to 113x106. The absolute volume of smooth surfaced endoplasmic reticulum (SER) per Leydig cell amounted in aged rats to 78% of that in young adult rats. The total amount of SER in paired testes increased by 62% with aging. The present analysis suggests that the ability of SER to maintain peripheral testosterone concentration decreases with age. In young adult rats the absolute volume of peroxisomes per Leydig cell correlated significantly with the concentration of testosterone in blood and also with the absolute volume of SER per Leydig cell. These results combined with ultrastructural observations of close apposition of peroxisomes and SER suggest that peroxisomes have a role in testosterone secretion by Leydig cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318610
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  • 3
    Electronic Resource
    Electronic Resource
    The fine structure of testicular interstitial cells in mice during postnatal development (1970)
    Springer
    Cell & tissue research 108 (1970), S. 475-486 
    Details
    ISSN: 1432-0878
    Keywords: Leydig cells ; mice ; Differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Testicular interstitial cells in ddN mice aged 3 to 28 days were studied with the electron microscope. They differed from those in adult mice in several respects: 1) Agranular endoplasmic reticulum and granular endoplasmic reticulum were mixed in the youngest animals, while they were separated topographically in 28 day mice. 2) Mitochondria were usually round between 3 to 10 days, while oval or rod-shaped mitochondria predominated in 28 day animals. Intramitochondrial granules were absent between 3 to 10 days but were occasionally observed in the older animals. 3) Glycogen particles were occasionally arranged in irregular clusters in 3 day old animals, while these structures were absent in the older animals. 4) Membranous whorls were recognized only in 28 day mice. 5) Villous processes on the cell surface facing the perivascular space were poorly developed in the youngest animals, while in 28 day mice they were as prominent as in the adult mouse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00339654
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  • 4
    Electronic Resource
    Electronic Resource
    Cholesterol changes in developing testicular interstitial cells of the mouse: Histochemical and biochemical study (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 595-601 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: In combination with biochemical determination of cholesterol in testes, cholesterol was studied histochemically in the testicular interstitial cells of dd strain mice from 5 to 63 days.Cholesterol is found in interstitial cells at five days and cholesterol positive interstitial cells increase significantly from 7% at 5 days to 47% at 21 days (17% at 7 days, 21% at 10 days and 31% at 14 days) and thereafter gradually to 58% at 63 days (50% at 28 days, 54% at 35 days, 56% at 42 days, 58% at 49 days and 57% at 56 days).The cholesterol concentration of testes (μg of cholesterol per mg testicular weight) remains at low values before 42 days (1.33 at 5 days, 2.12 at 7 days, 1.89 at 10 days, 2.18 at 14 days, 2.16 at 21 days, 1.63 at 28 days and 2.09 at 35 days) but it increases rapidly at days 42-49 (2.21 at 42 days and 5.16 at 49 days) and then it is almost unchanged (5.47 at 56 days and 5.18 at 63 days).From these results it is suggested that (1) at five days testicular steroid could be elaborated and (2) the capacity of interstitial cells to produce testicular steroid elevates actively from 42 to 49 days.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091630411
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  • 5
    Electronic Resource
    Electronic Resource
    The fine structure of ventral prostatic secretory epithelial cells in older rats (1979)
    Springer
    Cell & tissue research 203 (1979), S. 181-188 
    Details
    ISSN: 1432-0878
    Keywords: Ventral prostate ; Epithelial cells ; Electron microscopy ; Light microscopy ; Older rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The ventral prostatic secretory epithelial cells in older rats were studied by light and electron microscopy. The cells vary in height in different parts of the same organ, and ultrastructurally they show the presence of a developed secretory apparatus such as well-developed Golgi body and abundant rough endoplasmic reticulum. They also show signs of a depressed secretory activity, involving occasional emiocytosis of apical secretory vacuoles and a paucity of condensing vacuoles in the Golgi region and above it. Further, they are characterized by the frequent occurrence of supra and paranuclear pleomorphic lysosomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237232
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  • 6
    Electronic Resource
    Electronic Resource
    Some ultrastructural effects of testosterone and insulin on the ventral prostate of rats in organ culture (1977)
    Springer
    Cell & tissue research 181 (1977), S. 327-337 
    Details
    ISSN: 1432-0878
    Keywords: Prostate ; Tissue culture ; Testosterone ; Insulin ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The fine structure of the secretory epithelial cells of rat's ventral prostate has been studied following organ culture. Culturing with either testosterone or insulin alone, and with the two hormones combined, were carried out to investigate how insulin modifies the action of testosterone on the maintenance of cellular integrity. After 4 days in hormone-free culture, the secretory epithelial cells showed signs of cellular atrophy and regression, involving loss of the apical microvilli, absence of the apical secretory vacuoles, atrophy of the Golgi apparatus, decrease in rough endoplasmic reticulum and the appearance of autophagic vacuoles. The presence in the medium of either testosterone or insulin alone, or combined, prevented cellular atrophy and regression. The best maintenance of cellular integrity was obtained in a culture containing both hormones. The effects of insulin was approximately equivalent to those of testosterone in the maintenance of cellular integrity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00223108
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  • 7
    Electronic Resource
    Electronic Resource
    Stereologic and fine-structural studies of prostatic acinar basal cells in the dog (1985)
    Springer
    Cell & tissue research 242 (1985), S. 519-525 
    Details
    ISSN: 1432-0878
    Keywords: Prostate gland ; Basal cell ; Fine structure ; Stereology ; Dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary There are two distinct types of epithelial cells in the lining of the glandular acini of the prostate in adult male Beagle dogs, i.e., the columnar secretory epithelial cells and the basal cells. In contrast to the secretory epithelial cells, basal cells exhibit an abundance of micropinocytotic vesicles on their basal surface. Blood capillaries are often found in the stromal tissue in close proximity to these cells and their walls frequently display chains of fenestrations bridged by diaphragms. Stereological analysis shows that the volume density of the basal cells in the reference volume of acinar parenchyma is 0.056, and there are approximately 132.14 million cells per cm3 of prostatic tissue. An average basal cell has a volume of 373.5 μm3, and the volume densities of its nucleus, rough endoplasmic reticulum, Golgi apparatus, mitochondria and micropinocytotic vesicles, are 0.49, 0.04, 0.04, 0.094 and 0.013, respectively. These data are distinctly different from those that have been reported for the prostatic secretory epithelial cells of the same animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225417
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  • 8
    Electronic Resource
    Electronic Resource
    Light and electron microscopy of the ducts and their subepithelial tissue in the rat ventral prostate (1978)
    Springer
    Cell & tissue research 192 (1978), S. 381-390 
    Details
    ISSN: 1432-0878
    Keywords: Prostatic duct ; Epithelium ; Basal cell ; Muscular coat ; Fine structure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The ducts of the rat ventral prostate have been studied by light and electron microscopy for elucidation of their role in prostatic function. The epithelium of the main duct consists of simple columnar cells and polymorphic basal cells. The columnar cells show no indication of secretory activity. The basal cells contain bundles of filaments of 5–6 nm thickness and numerous pinocytotic vesicles. The ducts are surrounded by layers of circular smooth muscle cells interspersed with nerve axons. On ultrastructural grounds the ducts do not appear to secrete material into the seminal fluid, but apparently the muscular coat actively helps drain the gland during ejaculation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00212320
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  • 9
    Electronic Resource
    Electronic Resource
    Bone formation by cells from femurs cultured among three-dimensionally arranged hydroxyapatite granules (1997)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 37 (1997), S. 1-8 
    Details
    ISSN: 0021-9304
    Keywords: osteoblasts ; culture system ; hydroxyapatite ; three-dimensional configuration ; mineralization ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: In vitro bone formation by cells derived from adult rabbit femurs was investigated on or in several substrates with small porous hydroxyapatite granules (HAGs). When the bone fragments were cultured in HAG-packed glass tubes, which were inclined (5°-30°) and rotated 90 degrees per day after one week of culture, thin lamellar tissues were newly formed in narrow spaces among the HAGs. By 11 days of culture, these tissues had been mineralized except for their periphery and had well developed collagen bundles and several monolayer cells. Some cells resided in bone lacuna-like spaces. By contrast, mineralization was negligible in 6-week cultures on two-dimensional glass and polystyrene plates with or without two-dimensionally arranged HAGs on their surfaces and in three-dimensional collagen gels with or without HAGs in spite of active cell proliferation. These results suggest that osteogenesis is accelerated in a specific three-dimensional constitution of extracellular matrix and/or under the effects of mechanical forces for the new tissue and that bioactive HAGs offer favorable three-dimensional spaces for osteogenic tissue formation. © 1997 John Wiley & Sons, Inc. J Biomed Mater Res, 37, 1-8, 1997.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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