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  • 1
    Electronic Resource
    Electronic Resource
    Remote subarachnoid haemorrhage in the posterior fossa following supratentorial surgery (1994)
    Springer
    Acta neurochirurgica 129 (1994), S. 158-165 
    Details
    ISSN: 0942-0940
    Keywords: Subarachnoid haemorrhage ; posterior fossa ; supratentorial craniotomy ; postoperative complication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Haemorrhage in regions remote from the site of following intracranial operations is rare, but they do occur. We performed supratentorial craniotomy on 639 patients between the time of introduction of computed tomography (CT) for clinical use in 1983 and June 1992; subarachnoid haemorrhage (SAH) in the posterior fossa occurred postoperatively in six of these cases. These included four patients with tumours in the sellar region, one with an arteriovenous malformation (AVM) and one who underwent superficial temporal artery (STA)-middle cerebral artery (MCA) anastomosis. The ages of the six patients ranged from 17–72 years. Haemorrhage occurred on the day of operation in one case and was detected on CT examination on the day following surgery in the remaining five cases. Of three patients with disturbance of consciousness, two underwent suboccipital craniectomy for reduction of intracranial pressure, while one received barbiturate therapy and later underwent cerebrospinal fluid (CSF) shunt surgery. No special treatment was necessary for the remaining three patients with less serious lesions. Five of the six patients ultimately recovered their pre-operative neurological status apart from the primary diseases. Factors inducing such haemorrhages seem likely to include displacement of the cerebellum by reduced CSF pressure during and after operations, and stretching and tearing of the veins and venules in the sulci of the tentorial surface of the cerebellum. Consideration should therefore be given to the maintenance of an appropriate CSF pressure during operation; this is particularly important in elderly patients and those with an atrophied cerebral cortex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01406496
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cellular targets of exogenous tumour necrosis factor-alpha (TNFα) in human gliomas (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 1437-1441 
    Details
    ISSN: 0942-0940
    Keywords: TNF-binding sites ; gliomas ; endothelial cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To identify the cellular targets of TNFα in human gliomas, a total of 30 surgical specimens (12 glioblastomas, 4 anaplastic astrocytomas, 3 astrocytomas, 7 brains adjacent to tumour (BAT), 4 histologically normal-appearing brains) were examined by in vitro binding technique using biotinylated TNFa. The TNF-binding sites (TNF-BS) were recognized in the tumour cells in 8 of the 12 glioblastomas. 3 of the 4 anaplastic astrocytomas and in all the 3 astrocytomas. The TNF-BS were also recognized in the vascular endothelial cells in all these cases. The presence of TNF-BS in blood vessels ranged from 7.7 to 74.4% of the background vessels. This wide range of variation in the presence of TNF-BS within the tumour cells and tumour blood vessels may be relevant to the variable response of individual tumours to TNFα therapy. Since the tissue of normal brain, which lacks TNF-BS, might hardly be affected by this cytokine, administration of TNFa may be considered as an adjuvant therapy in selected groups of patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411123
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Hemangioblastoma of the third ventricle (1999)
    Springer
    Neurosurgical review 22 (1999), S. 140-144 
    Details
    ISSN: 1437-2320
    Keywords: Key words Brain neoplasm ; Hemangioblastoma ; Third ventricle tumor ; von Hippel-Lindau syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A third ventricle tumor, in addition to a recurrent cerebellar hemangioblastoma, was found in a 47-year-old woman on follow-up magnetic resonance imaging (MRI) 5 years after operation of the cerebellar tumor. On MRI, the tumor was hypo- to isointense on T1-weighted images and hyperintense on T2-weighted images compared with the normal gray matter, and was strongly enhanced with gadolinium. The tumor was first treated with fractionated conventional external-beam radiation (5120 cGy in 16 fractions over a 4-week period), resulting in a slight decrease in size of the tumor. For a definite diagnosis and mass reduction, surgery was performed using an interhemispheric translamina terminalis approach, resulting in a partial removal of the tumor due to profuse bleeding. Histological diagnosis was hemangioblastoma. Hemangioblastomas of the third ventricle are extremely rare and have not been specifically discussed. We describe the detailed clinicopathological features of the present case together with the possible explanation for the development of this tumor in this rare location.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101430050050
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    Paper (German National Licenses)
    Fulltext
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