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  • 1
    Electronic Resource
    Electronic Resource
    Development of AChE-positive, NA-containing and VIP- and NPY-immunoreactive nerves in the major cerebral arteries of the rat (1991)
    Springer
    Anatomy and embryology 184 (1991), S. 25-32 
    Details
    ISSN: 1432-0568
    Keywords: Ontogeny ; Cerebrovascular innervation ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The development of cerebrovascular nerves containing noradrenalin (NA), acetylcholinesterase (AChE), neuropeptide Y (NPY), and vasoactive intestinal polypeptide (VIP) was studied in rats from before birth to adulthood. All these nerves entered the cranial cavity along the cerebral carotid, internal ethmoidal, and vertebral arteries during the early stages of development, but the subsequent growth and distribution of NA-containing and NPY-immunoreactive (IR) nerves differed greatly from that of AChE-positive and VIP-IR nerves. NA-containing and NPY-IR nerves extended rapidly from the cerebral carotid artery and spread over all the major arteries of the internal carotid system by postnatal day 3, as well as descending the posterior ramus of the cerebral carotid to mingle with nerves from the vertebral artery around the mid-basilar artery by day 5. AChE-positive and VIP-IR nerves from the internal ethomoidal artery covered the whole internal carotid system during the first postnatal week, and projected to the upper basilar artery after the second week, while those from the cerebral carotid artery remained limited to the middle cerebral artery throughout development. By day 21, all major arteries of the internal carotid system had dense plexuses of the four nerve types that were similar to those observed in adult rats. The vertebrobasilar system also had a well-organized network of NA-containing and NPY-IR nerves, but only a poor supply of AChE-positive and VIP-IR nerves. Even on day 30, the latter two nerve types were sometimes absent from the middle to caudal basilar artery, owing to a lack of interdigitation by nerves from the internal ethomoidal and vertebral arteries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01744258
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrasonic absorption study of the complex formation of zinc(II) chloroacetate and n-butyrate in aqueous solution (1993)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 97 (1993), S. 4820-4824 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100120a039
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  • 3
    Electronic Resource
    Electronic Resource
    An adenosine uptake blocker, propentofylline, reduces glutamate release in gerbil hippocampus following transient forebrain ischemia (1992)
    Springer
    Neurochemical research 17 (1992), S. 147-150 
    Details
    ISSN: 1573-6903
    Keywords: Propentofylline ; adenosine ; gerbil hippocampus ; glutamate ; microdialysis ; transient ischemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the present study, the effect of the adenosine uptake blocker, propentofylline (HWA 285) on the extracellular concentration of several amino acids including glutamate, glycine and taurine following 10 min of forebrain ischemia in gerbil hippocampus was investigated using in vivo microdialysis. Pretreatment with HWA 285 (20 mg/kg i.p.) significantly reduced the extracellular concentration of glutamate following ischemia but did not significantly alter levels of other amino acids such as glycine and taurine. These findings suggest that the neuroprotective effect of HWA 285 may be associated with inhibition of glutamate release in the gerbil hippocampus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00966792
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  • 4
    Electronic Resource
    Electronic Resource
    Apolipoprotein E ε4 allele and progression of cortical Lewy body pathology in Parkinson’s disease (1998)
    Springer
    Acta neuropathologica 95 (1998), S. 450-454 
    Details
    ISSN: 1432-0533
    Keywords: Key words Apolipoprotein E gene ; Cortical Lewy body ; Amyloid plaque ; Parkinson’s disease ; Dementia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To elucidate whether the apolipoprotein E ɛ4 allele (APOE4) affects cortical neuropathology in Parkinson’s disease (PD), we determined APOE genotypes and quantified the densities of cortical Lewy bodies (LBs), amyloid plaques and neurofibrillary tangles in 22 autopsy-proven PD cases (12 with dementia; 10 without dementia) that were not accompanied by Alzheimer’s disease. The APOE4 frequency in the demented patient group was 0.21, which was significantly higher than that in Japanese controls (P 〈 0.04). LB densities in demented PD patients were significantly higher than those in non-demented PD patients, despite the shorter disease duration in the former. Moreover, plaque density in the temporal cortex and LB density in the cingulate cortex were significantly higher in the group with APOE4 than in that without the allele. There was no difference in tangle density between these two groups. These results suggest that APOE4 may influence the increase in the number of cortical LBs and amyloid plaques in PD. It is possible that when PD occurs in individuals with APOE4, concomitantly evolving cortical LB pathology in a proportion of cases results in limbic (transitional) or neocortical-type LB disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050824
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  • 5
    Electronic Resource
    Electronic Resource
    Autosomal dominant diffuse Lewy body disease (1998)
    Springer
    Acta neuropathologica 96 (1998), S. 207-210 
    Details
    ISSN: 1432-0533
    Keywords: Key word Diffuse Lewy body disease ; Apolipoprotein E gene ; Autosomal dominant ; Parkinson’s disease ; Dementia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe a Japanese family with parkinsonism and later-onset dementia. The proband developed parkinsonism at the age of 61 years, followed by dementia starting when she was 67. Her uncle, who was also her husband, died at the age of 78 years after 7- and 5-year histories of parkinsonism and dementia, respectively. Pathological examination of these two patients showed marked neuronal loss with Lewy bodies (LBs) in the brain stem pigmented nuclei and numerous cortical LBs and ubiquitin-positive hippocampal CA2/3 neurites were observed. The proband also had many amyloid plaques. Their two sons developed similar parkinsonism at the ages of 39 and 28 years and also suffered later-onset dementia. The apolipoprotein E genotype of the proband, her uncle and one of their sons was ɛ3/4 and that of the other son was ɛ4/4. These findings strongly suggest that this family has autosomal dominant diffuse LB disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050883
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  • 6
    Electronic Resource
    Electronic Resource
    Jasmonate-inducible expression of a potato cathepsin D inhibitor-GUS gene fusion in tobacco cells (1994)
    Springer
    Plant molecular biology 26 (1994), S. 403-414 
    Details
    ISSN: 1573-5028
    Keywords: cathepsin D inhibitor ; methyl jasmonate ; promoter analysis ; transformed tobacco cells ; tuberonic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A potato gene encoding cathepsin D inhibitor (CDI) is expressed constitutively in tubers and flower buds and it is inducible in leaves upon wounding of the tissue or by treatment with methyl jasmonate (MJA). A fusion gene (CDI:GUS) in which the 2.4 kb long promoter of the CDI gene was translationaly fused with the coding sequence for β-glucuronidase (GUS) showed MJA-inducible expression in transformed tobacco cells in suspension. The maximum level of induction by MJA was obtained in the absence of auxin and repression of MJA-inducible expression of the fusion gene by auxin was released by aphidicolin, the results suggesting that MJA-inducible expression is repressed during active cell division. JA and MJA showed similar activities in inducing the expression of the fusion gene, while other JA-related compounds such as cucurbic acid, tuberonic acid and dihydrojasmonic acid neither induced expression of the fusion gene nor inhibited the MJA-inducible expression of the fusion gene. Methyl dihydrojasmonate specifically stimulated the MJA-inducible expression of the fusion gene. The MJA-inducible expression of the fusion gene was observed even with a 100 bp long promoter of the CDI gene albeit with significantly decreased level of expression compared to the 2.4 kb long promoter. The 100 bp long CDI promoter did not contain a G-box or hexamer motif that had been implicated in the MJA-responsive expression of several other plant genes. Further mutagenesis of the 100 bp long promoter by deletion or oligonucleotide insertion suggested that although a sequence between −100 and −82 is required for the MJA-responsive expression, the presence of this sequence alone does not confer the MJA-responsive expression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00039549
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  • 7
    Electronic Resource
    Electronic Resource
    Characterization of the putative α subunit of a heterotrimeric G protein in rice (1997)
    Springer
    Plant molecular biology 34 (1997), S. 563-572 
    Details
    ISSN: 1573-5028
    Keywords: ADP ribosylation ; α subunit ; cholera toxin ; heterotrimeric G protein ; rice ; signal transduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A recombinant protein with a cDNA that encodes the putative α subunit of a rice heterotrimeric G protein was synthesized in Escherichia coli and purified. The recombinant protein (rGrice α) with an apparent molecular mass of 45 kDa was bound with guanosine 5′-(3-O-thio)triphosphate with an apparent association constant (kapp) of 0.36. The protein also hydrolyzed GTP and its Kcat was 0.44. rGrice α was ADP-ribosylated by activated cholera toxin. Monoclonal antibodies raised against rGrice α reacted with a 45 kDa polypeptide localized in the plasma membrane of rice seedlings. The peptide map of this polypeptide after digestion with V8 protease was identical to that of rGrice α. A 45 kDa polypeptide in the plasma membrane, as well as rGrice α, was ADP-ribosylated by activated cholera toxin. The GTPase activity of the plasma membrane was stimulated 2.5-fold by mastoparan 7 but not mastoparan 17. These properties were similar to those of the α subunits of heterotrimeric G proteins in animals, suggesting that the putative α subunit is truly the α subunit itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005807010811
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  • 8
    Electronic Resource
    Electronic Resource
    Refinement of the gene locus for autosomal recessive juvenile parkinsonism (AR-JP) on chromosome 6q25.2-27 and identification of markers exhibiting linkage disequilibrium (1998)
    Springer
    Journal of human genetics 43 (1998), S. 22-31 
    Details
    ISSN: 1435-232X
    Keywords: Key words Autosomal recessive juvenile parkinsonism (AR-JP) ; Parkinson's disease (PD) ; Chromosome 6q25.2-27 ; Linkage disequilibrium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Autosomal recessive juvenile parkinsonism (AR-JP) (MIM 600116) is a hereditary neurodegenerative disorder characterized by levodopa-responsive parkinsonism with a mean age at onset of 23.2 years. We recently mapped the AR-JP gene locus to a 17-cM interval on chromosome 6q25.2-27. To further narrow the candidate region of the AR-JP gene, we performed detailed linkage analysis using densely placed genetic markers in this region (D6S437, D6S1581, D6S1579, D6S305, D6S411, SOD2, D6S253, D6S1599, D6S1719 and D6S264). Pairwise linkage analysis revealed the highest cumulative maximal lod score of 9.13 at D6S1579 (θ = 0.05), and multipoint linkage analysis revealed the highest cumulative lod score of 12.4 at the locus 3 cM telomeric to D6S1599. Observation of obligate recombination events narrowed the candidate region to a 13-cM region between D6S1579 and D6S264. Furthermore, we identified two marker loci, D6S1579 and D6S1599, which exhibit strong linkage disequilibrium with the AR-JP locus: χ2 (2 ×n table) = 84.22; P 〈 0.0001, χ2 [likelihood-ratio test (LRT)] = 20.66; P 〈 0.0001, λ = 0.40 and χ2 (2 ×n table) = 63.37; P 〈 0.0001, χ2 (LRT) = 10.32; P 〈0.0001, λ = 0.30, respectively. These results suggest that the candidate region for the AR-JP gene is most likely located near the 4-cM region encompassing D6S1579 and D6S1599.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380050032
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