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  • 1
    Electronic Resource
    Electronic Resource
    Induction of Bacteriophage Formation in Lysogenic Bacteria by a Potent Carcinogen, 4-Nitroquinoline l-oxide, and its Derivatives (1963)
    [s.l.] : Nature Publishing Group
    Nature 198 (1963), S. 195-196 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] E. coli K12(X) during the logarithmic phage of growth was collected by centrifugation, resuspended at a cellular density of 2 x 108/ml. in X-broth4 containing appropriate concentrations of test chemicals and incubated at 37 under shaking. After 10 min, each suspension was diluted quickly, so that ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/198195a0
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  • 2
    Electronic Resource
    Electronic Resource
    Relation Between Tumouricidal and Prophage-Inducing Action (1963)
    [s.l.] : Nature Publishing Group
    Nature 198 (1963), S. 258-260 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN some lysogenic bacterial systems, the phage production leading to cell lysis can be induced by exposing the cultures to the action of various agents such as ultraviolet1, ionizing radiation2, nitrogen mustard3, mito-mycin C (ref. 4), etc. This phenomenon, though well known since the pioneer ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/198258a0
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  • 3
    Electronic Resource
    Electronic Resource
    Inactivation of cis-diamminedichloroplatinum (II) in blood and protection of its toxicity by sodium thiosulfate in rabbits (1985)
    Springer
    Cancer chemotherapy and pharmacology 15 (1985), S. 228-232 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The mode of inactivation of cis-diamminedichloroplatinum(II) (DDP) in the bloodstream and protection from its toxicity by sodium thiosulfate (STS) were investigated in rabbits. Plasma ultrafiltrate in rabbits given 5 mg/kg DDP IV and various excess molar ratios of STS IV were assayed for the active platinum levels with a new microbiological assay system using an E. coli strain. The active platinum species in the plasma were inactivated completely by coadministration of a 400-fold excess of STS IV. The rabbits were almost completely protected against both BUN increase and body weight loss normally caused by DDP when 400-fold doses of STS were given. Diuretic effects were also observed. Our data provide evidence for the basis of optimum use of STS to protect against DDP toxicity. [6, 9]. This TRC with DDP and STS is now in clinical trial [7, 8], but the precise mode of protective action of STS against DDP toxicity has not been determined. We now present evidence that this protective effect is due to inactivation of biologically active DDP in the bloodstream.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00263891
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  • 4
    Electronic Resource
    Electronic Resource
    Sodium thiosulfate inhibits cis-diamminedichloroplatinum (II) activity (1984)
    Springer
    Cancer chemotherapy and pharmacology 13 (1984), S. 82-85 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To elucidate the mechanisms of inactivation of cis-diamminedichloroplatinum(II) (DDP) toxicity by its antidote sodium thiosulfate (STS), we studied the effects of STS on plasma concentrations of platinum (Pt) in vivo, binding of Pt to serum protein in vitro, and uptake of Pt by bacterial cells (E. coli, WP 2 uvrA strain) or cultured mouse tumor cells (FM3A) in vitro. STS did not significantly affect either plasma levels of total Pt or non-protein-bound Pt in vivo, but did inhibit binding of Pt to serum protein and cellular uptake of Pt in vitro. These results suggest that when DDP is given in combination with STS in vivo, the binding to macromolecules and entry of DDP into the cells are prevented due to formation of the Pt-thiosulfate complex in the extracellular fluid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257119
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  • 5
    Electronic Resource
    Electronic Resource
    Mutagenicity of urine from young male smokers and nonsmokers (1987)
    Springer
    International archives of occupational and environmental health 59 (1987), S. 1-9 
    Details
    ISSN: 1432-1246
    Keywords: Mutagenicity ; Human urine ; Ames test ; Smoking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The mutagenicity of urine from a healthy population of young adult men (average age of 23 years), including 61 smokers and 107 nonsmokers, was investigated with the Salmonella/microsome test using the tester strain S. typhymurium TA98. In quantifying the assay, the use of dichloromethane was suitable for eluting the mutagenicity of smokers' urine from the XAD-2 resin column. We assayed mutagenicity in condensates of such dichloromethane eluates and found that the mutagenicity of smokers' urine was significantly higher than that of nonsmokers' urine. In the smokers' group, correlation coefficient between “the mutagenicity of the urine” and “the actual number of cigarettes smoked on the day of urine collection” or “the average number of cigarettes smoked per day” was statistically significant at 0.266 or 0.454, respectively. Our results suggest a correlation between the increase of mutagens in urine and smoking habits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00377673
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    Paper (German National Licenses)
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