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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 85 (1963), S. 2976-2983 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 85 (1963), S. 2988-2991 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 85 (1963), S. 2983-2988 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 336-338 (Apr. 2007), p. 730-734 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: BaRuO3(BRO) and BaIrO3(BIO) thin films were prepared by laser ablation, and the effects ofpreparation conditions on the structure, morphology and electrical conductivity were investigated. BROthin films deposited at oxygen partial pressure (PO2) = 13 Pa and substrate temperature (Tsub) 〈 573 Kwere amorphous. At Tsub = 573 K, the rhombohedral BRO thin films with (110) orientation were obtained.BRO thin films prepared at Tsub = 773 K and PO2= 13 Pa exhibited the resistivity of 5x10-6 [removed info]m andshowed metallic conduction. BIO thin films deposited at PO2= 40 Pa and Tsub 〈 623 K were amorphous.Tsub 〉 623 K, the BIO thin films crystallized into a 6H structure were obtained. The resistivity of the BIOfilms at PO2= 40 Pa decreased from 1.4x10-2 to 4x10-4 [removed info]m with decreasing Tsub from 1073 to 573 K
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1619-7089
    Keywords: Liver scan ; Technetium-99m ; Asialogly-coprotein ; Multicentre study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A multicentre study on multicompartmental analysis of hepatic scintigraphy using technetium-99m labelled galactosyl serum albumin (GSA), which binds to the asialoglycoprotein receptor, was carried out at seven institutions in Japan. Seventy-four patients with liver disease received 3 mg (185 MBq) of99mTc-GSA by intravenous injection. Sequential scanning was performed 30 min after injection to obtain anterior images of the heart and liver, followed by single-photon emission tomography (SPET). The indices included in this analysis were hepatic blood flow (Q) and maximal receptor binding rate (R max), which showed a good correlation with semiquantitative ratio indices for99mTc-GSA, namely the retention rate in blood (HH15) and the hepatic uptake rate (LHL15).Q andR max also showed a significant correlation with other measures of hepatic function. When patients were grouped according to the severity of chronic liver damage (hepatocellular functional damage),Q was reduced in the moderate and severe groups, whileR max was reduced in proportion to the functional stage. Both parameters showed no inter-institution difference using analysis of co-variance with the functional stage as a co-variant. With regard to the hepatic uptake rate, anterior planar images and SPET images gave similar results forQ andR max. Acquisition times of 15 or 30 min provided the same results. The multicopartmental model analysis permitted comparable results to be obtained at institutions using different gamma cameras, and is therefore considered a universally applicable method. These results indicate thatQ andR max are useful general indices for evaluating the function reserve capacity of the liver.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 475-479 (Jan. 2005), p. 1209-1212 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: SrRuO3 (SRO) thin films were prepared by laser ablation. The optimum preparation condition of highly electrically conductive SRO thin films was investigated. The substrate temperature (Tsub) was changed from room temperature to 973 K, and the deposition atmosphere was at a high vacuum (P = 10-6 Pa) and in O2 at oxygen pressures (PO2) of 0.13 and 13 Pa. The filmsdeposited at P = 10-6 Pa and PO2 = 0.13 Pa were amorphous structure. At Tsub 〉 573 K and PO2 = 13 Pa, well-crystallized pseudo-cubic SRO thin films with (110) orientation were obtained. With increasing Tsub, the conductivity of SRO films increased from 7.7×103 to 9.1×104 S·m-1. The epitaxially grown SRO films on (100) SrTiO3 substrates exhibited the highest conductivity of 1.8×105 S·m-1
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 352 (Aug. 2007), p. 315-318 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Epitaxial BaRuO3 (BRO) and CaRuO3 (CRO) thin films were prepared on (001), (110) and(111) SrTiO3 (STO) single-crystal substrates by laser ablation, and their microstructures andanisotropy of electrical conductivity were investigated. The (205) (104), (110) and (009) orientedBRO thin films, and (001), (110) and (110) oriented CRO thin films were grown epitaxially on (001),(110) and (111) STO substrates with in-plain orientation, respectively. The (009) BRO thin film and(001) CRO thin film has a flat surface result from a good lattice matching to STO substrates. The(205) (104) BRO thin film and (111) CRO thin film exhibited orthogonal- and hexagonal-shapedtexture, respectively. The (110) BRO thin film and (110) CRO thin film showed an island growth dueto (110) surface feature of cubic perovskite structure. Epitaxial BRO and CRO thin films have a highelectrical conductivity with a metallic conduction, the (111) CRO thin films exhibited the highestconductivity of 1.4×105 S·m-1
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-2592
    Keywords: Hepatitis C virus ; cytotoxic T lymphocytes ; transforming growth factor-β1 ; interleukin-10
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In hepatitis C virus (HCV) infection, TGF-β1 is upregulated in the liver and may be involved in the pathogenesis of chronic liver disease. TGF-β1 is also produced by activated T cells and acts as a potent immunosuppressor. The aim of this study was to investigate the roles of TGF-β1 in HCV-specific cytotoxic T lymphocyte (CTL) induction and enhance their killer activity by TGF-β1 modulation. We generated anti-HCV CTL from peripheral blood mononuclear cells from HLA-A2 patients under stimulation with the HCV-core peptide having the HLA-A2.1 binding motif. The lytic activities of CTL or precursor frequency (CTLpf) generated with or without anti-TGF-p antibody were compared. To optimize the IL-2 dose for CTL induction, low (50 U/ml) and high (500 U/ml) doses were tested and the lytic activities were compared. TGF-β1 amounts in the supernatants were assessed by enzyme-linked immunosorbent assay and by their growth inhibitory effect on mink lung epithelial cells. CTL activity was enhanced by anti-TGF-β antibody in a dose-dependent manner but CTLpf did not significantly change. A high dose of IL-2 reduced the activity to 45% of that observed with a low dose, whereas TGF-β1 increased as the dose of IL-2 increased. Exogenous IL-10 reversed the inhibitory effect of a high dose of IL-2 on the killing activity by reducing TGF-β1 mRNA expression in T cells and its production. These results demonstrated that endogenous TGF-β1 is an autocrine suppressor in CTL induction in vitro. Therefore, the blockade of endogenous TGF-β1 could enhance the killing potential of anti-HCV CTL.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-868X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract In the consideration of safety it is required that packages containing radioactive wastes when dumped at sea should keep their integrity and retain their contents until they reach the seabed. Packages containing simulated radioactive wastes (non-radioactive) were tested by a free-fall method at depthsca. 4,300 m in an area for dumping industrial waste off Shikoku Island. Since the weight of the largest package was 4,300 kg, special attention was paid to the connection of a buoyancy system with mooring rope. Descent and ascent velocities of the free-fall system were calculated prior to the experiment. A free-fall experiment with an extremely heavy object, heavier than ever previously reported, was accomplished without trouble by using the free-fall system. Recovery of a camera, flash-light, and other components was successful in each of the three experiments. Successive photographing of the package during descent was made and its integrity was observed using the photographs taken by the recovered camera. The packages remained intact during descent and at least for a short time after arrival on the seabed.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0360-6376
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The effect of homogeneity of polymerization phase and monomer concentration on the temperature dependence of initial polymerization rate was studied in the radiation-induced radical polymerization of binary systems consisting of glass-forming monomer and solvent. In the polymerization of a completely homogeneous system such as HEMA-propylene glycol, a maximum and a minimum in polymerization rates as a function of temperature, characteristic of the polymerization in glass-forming systems, were observed for all monomer concentrations. However, in the heterogeneous polymerization systems such as HEMA-triacetin and HEMA-isoamyl acetate, maximum and minimum rates were observed in monomer-rich compositions but not at low monomer concentrations. Furthermore, in the HEMA-dioctyl phthalate polymerization system, which is extremely heterogeneous, no maximum and minimum rates were observed at any monomer concentration. The effect of conversion on the temperature dependence of polymerization rate in homogeneous bulk polymerization of HEMA and GMA was investigated. Maximum and minimum rates were observed clearly in conversions less than 10% in the case of HEMA and less than 50% in the case of GMA, but the maximum and minimum changed to a mere inflection in the curve at higher conversions. A similar effect of polymer concentration on the temperature dependence of polymerization rate in the GMA-poly(methyl methacrylate) system were also observed. It is deduced that the change in temperature dependence of polymerization rate is attributed to the decrease in contribution of mutual termination reaction of growing chain radicals to the polymerization rate.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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